Prevalence and Predictors of Fatigue in Patients With Episodic Migraine

Abstract

The aim: We studied prevalence, intensity and predictors of fatigue in patient with episodic migraine (EM). Materials and methods: We enrolled in the study 85 patients with EM and 88 healthy subjects. Fatigue was identified according to Fatigue Severity Scale. We recorded socio-demographic factors: gender, age, marital status, formal education level, employment status, smoking. Anxiety and depression symptoms were assessed by Hospital Anxiety and Depression Scale, daytime sleepiness was measured by Epworth scale. The co-morbidities included history of low back pain during last year, arterial hypertension, diabetes mellitus and abdominal obesity. It was analyzed usage of non-steroidal anti-inflammatory drugs, combined analgesics, triptans for abortive migraine treatment. Results: Fatigue prevalence in patients with EM was 41,2%, which was significantly higher than in healthy controls (11,4%). Fatigue intensity in episodic migraineurs was 5,7 (4,9-6,8) and did not differ significantly from fatigue intensity in healthy individuals – 4,9 (4,5-5,8). In multivariate logistic regression analysis independent predictors of fatigue were only migraine-related factors (number of migraine headache days per month, headache severity and migraine prodrome presence). There was weak direct correlation between the number of headache migraine days per month and fatigue intensity. Conclusions: 1. Fatigue prevalence in patients with EM is significantly higher than in healthy controls. 2. In patients with EM fatigue has migraine-related predictors.

Serum Level of Brain-Derived Neurotrophic Factor and Thrombotic Type Are Predictive of Cognitive Impairment in the Acute Period of Ischemic Strokes Patients

“…The prevalence of dementia in the first 3–6 months after a stroke ranges from 5 to 32% and after 12 months from 8 to 26%. The highest risk of developing poststroke cognitive disorders is observed during the first months after a stroke, which is probably due to previously unrecognized and undiagnosed initial manifestations of cognitive disorders [ 23 ]. In our study, cognitive impairment was found in almost half of the patients on the first day of ischemic stroke, and there was no significant reduction in this prevalence over 2 weeks.…”

Personality Traits and Fatigue in Multiple Sclerosis: A Narrative Review

“…Primary fatigue is a direct consequence of the disease, while secondary fatigue is a consequence of reduced functional capabilities, chronic pain, and treatment side effects. It may be defined as a decrease in physical and/or mental performance [ 124 ]. Nevertheless, the present literature clearly reports that the definition of patients with fatigue often depends on the type of scale used and it might not represent the actual experience of the patient.…”

Early poststroke clinically significant fatigue predicts functional independence: a prospective longitudinal study

“…This study is subject to several limitations: (1) medications commonly prescribed for stroke patients, including sedatives, antiepileptics, pain medications, and antidepressants, may independently contribute to fatigue and may be differentially prescribed between ischemic and hemorrhagic strokes; (2) exclusion of patients unable to communicate their symptomatology, such as those with aphasia or altered states of consciousness ( 10 , 26–28 ); (3) other conditioning factors, such as neuroanatomical/biological aspects and unexamined comorbidities, likely influence the effects of fatigue on functional outcomes, particularly the lack of improvement in fatigue despite neurorehabilitation in ischemic strokes ( 15–17 , 19 , 28 ). Our data confirm the evolution of poststroke fatigue and associated factors reported elsewhere ( 25 , 29–31 ).…”