Prevalence and predictors of drug-related hospitalisation among patients visiting emergency departments of Addis Ababa city hospitals in Ethiopia: a multicentre prospective observational study

Abstract

ObjectivesThis study aimed to determine the prevalence, categories and predictors of drug-related hospitalisation (DRH) among patients visiting emergency departments of Addis Ababa city hospitals, Ethiopia.DesignA multicentre prospective observational study was conducted through patients’ interview and chart review.SettingsThe study was undertaken in three tertiary care hospitals in Addis Ababa, Ethiopia.ParticipantsA total of 423 patients fulfilling the inclusion criteria were included.Outcome measuresPrevalence and preventability of DRH, categories of drug-related problems causing DRH, medications and diseases involved in DRH, and factors significantly associated with DRH.ResultMore than half of the patients (216, 51.1%) were female. The mean age (SD) was 47.50 (±17.21) years. The mean length of hospital stay (SD) was 10.29 (±8.99) days. Nearly 60% (249) of them were hospitalised due to drug-related problems, of which 87.8% were preventable. The cause for hospitalisation for more than half (130, 53%) of them was a failure to receive drugs, and 37.85 (94) patients were categorised as untreated indications. Age ≥65 years (adjusted OR (AOR)=7.451, 95% CI: 1.889 to 29.397), tertiary educational level (AOR=0.360, 95% CI: 0.141 to 0.923), participants who did not have any occupation (AOR=3.409, 95% CI: 1.120 to 10.374) and presence of comorbid conditions (AOR=2.004, 95% CI: 1.095 to 3.668) were predictors of DRH.ConclusionNearly 90% of DRH was deemed to be preventable in the study settings. Older age, lower educational level, unemployment and presence of comorbid conditions in hospital as an inpatient were predictors of DRH.

Medication-Related Hospital Admission Among Patients Admitted to the Emergency Ward at the University of Gondar, North West Ethiopia: A Cross Sectional Study

“…In the present study the most common category of DRP that result in MRHA was noncompliance, 41.4% (95% CI = 33.1–50). This result is similar with studies done in Ethiopia, 16 , 18 India, 33 and Saudi-Arabia. 34 In this study most patients discontinued their mediation when they were “feeling well” 35.85%.…”

“…The result is consistent with a study done in Ethiopia 18 and Spain. 26 A much higher prevalence was observed in a study done in Ethiopia (57.9%) 16 and Sweden (41.3%). 6 The prevalence in the present study is lower than the study done in Ethiopia stated previously.…”

“…Furosemide was the most common 16 medication associated with the DRP category non-compliance, followed by Amlodipine 2 and Enalapril 11 ( Figure 4 ).

Figure 4 Lists of medications that patients were taking associated with DRP categories at the emergency ward of UoGCSH from June 1, 2022 to August 30, 2022G.C.

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Drug-Related Hospital Admissions via the Department of Emergency Medicine: A Cross-Sectional Study From the Czech Republic

“…Compared to lower-income countries, we have observed a lower prevalence of DRAs related to Antiinfectives for systemic use. Antiinfectives for systemic use were frequently involved in DRAs in Ethiopia ( Angamo et al, 2017 ; Demessie and Berha, 2022 ), South Africa ( Mouton et al, 2016 ), Nigeria ( Adedapo et al, 2021 ), and India ( Geer et al, 2016 ). Antiinfectives for systemic use were also frequently implicated in DRAs in Brazil ( de Paula et al, 2012 ) during the time when the requirement to be prescription only was not met.…”

Drug-related problems among esophageal, gastric and colorectal cancer patients at the National and referral hospital in Kenya

“…4 However, a substantial proportion of DRPs are potentially preventable. [5][6][7][8] A previous study by Chan et al 9 demonstrated that most (94.5%) DRP-related hospital admissions were due to adverse drug reactions. The average mortality rate among hospitalised patients due to DRPs is 2.7%.…”