Prevalence and predictors of delayed gastric emptying among Indian patients with long-standing type 2 diabetes mellitus

Anudeep, Venkata; Vinod, Kolar Vishwanath; Pandit, Nandini; Sharma, Vivek; Halanaik, Dhanapathi; Dutta, Tarun Kumar; Akkilagunta, Sujiv

doi:10.1007/s12664-016-0694-4

Cited by 26 publications

(32 citation statements)

References 24 publications

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“…Although this amount was less than our results, it should be considered that in their study gastric emptying half time has been used for the evaluation of gastroparesis (10). Anudeep et al (12) evaluated the prevalence and predictors of delayed gastric emptying among 140 patients with type 2 diabetes mellitus in which delayed gastric emptying was detected in about 29 % (40/140) of type 2 diabetes patients.…”

Section: Discussionmentioning

confidence: 99%

“…Based on radionuclide scintigraphy results on gastric emptying in diabetic patients, the prevalence of delayed gastric emptying has been reported as 25-55% and 30% in patients with type 1 and 2 diabetes, respectively (10,11,12). Also, it has been determined that 29% of patients with gastroparesis had diabetes mellitus (13).…”

Section: Introductionmentioning

confidence: 99%

“…For example, acute alterations in blood glucose concentration can change gastric emptying time of both liquid and solid meals (14). Although the pathogenesis of gastroparesis has been attributed to poorly controlled hyperglycemia, some researches did not show a correlation between gastroparesis and autonomic dysfunction (4,12,15). Another study reported a correlation between diabetic gastroparesis and cardiovascular disease and retinopathy (16).…”

Section: Introductionmentioning

confidence: 99%

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Assessment of the Prevalence of Diabetic Gastroparesis and Validation of Gastric Emptying Scintigraphy for Diagnosis

Alipour¹,

Khatib²,

Tabib³

et al. 2017

Mirt

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Objective:Gastroparesis is defined as delayed gastric emptying and is a common medical condition in diabetic patients. Scintigraphy is commonly used as a standard diagnostic procedure for the quantitative assessment of gastroparesis. The aims of this study were to determine an optimum imaging time for the diagnosis of gastroparesis, to assess the prevalence of gastroparesis, to evaluate the correlation between endoscopy and scintigraphy findings as well as the correlation between gastric emptying with patient genders, blood glucose concentration, and functional dyspepsia.Methods:Gastric emptying was assessed in 50 diabetic patients with a mean age of 50.16 years. For evaluation of gastric emptying, a test meal containing 2 pieces of toast, 120 cc non-labeled water and fried egg labeled with 1 mCi of 99mTc was given to each patient. The scintigraphy was performed immediately after ingestion and was repeated at 1, 1.5, 2 and 4 hours after ingestion. In some patients, an additional 90-minute dynamic scan was also acquired.Results:The prevalence of gastroparesis in this study population was determined as 64%. Also, the results of this study revealed that a 4-hour scan after ingestion is more relevant than a 90-minute dynamic scan for the evaluation of delayed gastric emptying. There was no statistically significant difference between 1-hour and 2-hour scans, 1-hour and 90-minute scans, 2-hour and 90-minute scans, 2-hour and 4-hour scans. Likewise there was no significant correlation between blood glucose levels, gender and calculated values of gastric emptying time in all groups.Conclusion:According to our findings, it can be suggested that the prevalence of gastroparesis is higher than that mentioned in some previous studies. Also, this study indicates that a gastric emptying scintigraphy at 2 and 4 hours after meal ingestion might provide the anticipated clinical information in diabetic patients with dyspepsia without other evident reasons.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Assessment of the Prevalence of Diabetic Gastroparesis and Validation of Gastric Emptying Scintigraphy for Diagnosis

Alipour¹,

Khatib²,

Tabib³

et al. 2017

Mirt

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“…The role of gastric emptying in the pathogenesis of symptoms of suggestive of gastroparesis has been controversial, with some studies suggesting an association between delayed gastric emptying and upper symptoms (Table 2) [41][42][43][44][45][46][47][48][49][50][51][52][53][54][55][56][57][58], while others not demonstrating an association (Table 3) [59][60][61][62][63][64]. A large single-center study with 1499 patients undergoing GES for clinical evaluation found 629 (42%) patients to have delayed 4 h gastric emptying [65].…”

Section: Role Of Gastric Emptying In Symptoms Of Gastroparesismentioning

confidence: 99%

“…Amongst patients with symptoms suggestive of Gp, a considerable proportion have normal gastric emptying [6]. The majority of these patients with symptoms but normal gastric emptying are diagnosed with the Rome diagnoses of functional dyspepsia or chronic nausea and vomiting syndrome, or the GpCRC term of Chronic Unexplained Nausea and Vomiting [6,61]. Assessment of gastric emptying may have important therapeutic implications in patients with symptoms of dyspepsia.…”

Section: Role Of Gastric Emptying In Symptoms Of Gastroparesismentioning

confidence: 99%

Role of Gastric Emptying in Symptoms of Gastroparesis

Jehangir

Parkman

2019

Gastrointestinal Disorders

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The symptoms of gastroparesis, such as nausea, vomiting, postprandial fullness, early satiety and abdominal pain, frequently impair the quality of life of the affected individuals. The diagnosis of gastroparesis is made after structural etiologies are ruled out and an assessment of gastric function shows delayed gastric emptying. The role of the delay in gastric emptying in the pathogenesis of symptoms of gastroparesis has been debated, with some studies suggesting an association between delayed gastric emptying and the upper gastrointestinal symptoms, while others do not. The recent literature supports the importance of using reliable methods to assess gastric emptying, as delay in gastric emptying measured on a reliable test (4-h scintigraphy or breath test) is associated with the severity of upper gastrointestinal symptoms. In addition to measuring total gastric emptying, evaluation of regional gastric retention in the proximal and distal stomach and whole gut transit to assess small intestinal and colonic transit may provide additional useful information in patients with more generalized symptoms of gastrointestinal dysmotility.

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Symptoms Suggestive of Gastroparesis in a Community-Based Cohort of European Americans and African Americans with Type 2 Diabetes Mellitus

Brown

Freedman

et al. 2019

Dig Dis Sci

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Prevalence and predictors of delayed gastric emptying among Indian patients with long-standing type 2 diabetes mellitus

Cited by 26 publications

References 24 publications

Assessment of the Prevalence of Diabetic Gastroparesis and Validation of Gastric Emptying Scintigraphy for Diagnosis

Assessment of the Prevalence of Diabetic Gastroparesis and Validation of Gastric Emptying Scintigraphy for Diagnosis

Role of Gastric Emptying in Symptoms of Gastroparesis

Symptoms Suggestive of Gastroparesis in a Community-Based Cohort of European Americans and African Americans with Type 2 Diabetes Mellitus

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