Prevalence and Predictors of Columnar Lined Esophagus in Gastroesophageal Reflux Disease (GERD) Patients undergoing upper endoscopy

Balasubramanian, Gokulakrishnan; Singh, Mandeep; Gupta, Neil; Gaddam, Srinivas; Giacchino, Maria; Wani, Sachin; Moloney, Brian; Higbee, April D.; Rastogi, Amit; Bansal, Ajay; Sharma, Prateek

doi:10.1038/ajg.2012.299

Cited by 61 publications

(30 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…ordinary risk factors for BE (e.g. male gender, heartburn, hiatal hernia) cannot be applied for BE <1 cm in length [21], a condition that is sometimes associated with the presence of gastric mucosal atrophy and metaplasia [2]. Hence, the risk factors in Asian people for distinct BE with a length >2-3 cm, which is often encountered in Western countries, are largely unknown [22].…”

Section: Introductionmentioning

confidence: 99%

Association between the Body Mass Index and the Risk of Barrett's Esophagus in Japan

Shinkai

Iijima²,

Koike³

et al. 2014

Digestion

View full text Add to dashboard Cite

Background: We investigated the association between long-segment Barrett's esophagus and obesity in the Japanese population in a multicenter case-control trial. Methods: One hundred thirteen patients with endoscopically detected Barrett's esophagus with a length of more than 2 cm and the same number of sex- and age-matched controls were prospectively enrolled. Barrett's esophagus was diagnosed based on the Prague C and M criteria. The body mass index (BMI) of the subjects was categorized into the following groups: normal, BMI <22.9; overweight, BMI 23.0-24.9, and obese, BMI >25.0. To determine the association between BMI and the risk of Barrett's esophagus, multivariate logistic regression analyses were performed. Results: The basically adjusted regression model adjusted for smoking and alcohol consumption revealed that overweight and obesity were significantly associated with an elevated risk of Barrett's esophagus (OR 2.4, 95% CI 1.2-4.7, and OR 2.5, 95% CI 1.3-4.6, respectively). The intensity of the association was not attenuated even after adjustment for gastroesophageal reflux disease-related parameters. Conclusions: An increased BMI was associated with an increased risk for Barrett's esophagus through a gastroesophageal reflux-independent mechanism in the Japanese population. Further, unlike in Caucasian populations, being even slightly overweight with a BMI of 23.0-24.9 was an independent risk factor in the Japanese population.

show abstract

Section: Introductionmentioning

confidence: 99%

Association between the Body Mass Index and the Risk of Barrett's Esophagus in Japan

Shinkai

Iijima²,

Koike³

et al. 2014

Digestion

View full text Add to dashboard Cite

show abstract

“…The study reporting the lowest rate of histopathological BE diagnosis was conducted in Spain (0.08%) (48). The highest prevalence of BE was detected in the USA (14.1%) (49).…”

Section: The Epidemiology Of Gerd Complications In Turkey and Around mentioning

confidence: 99%

How is the gastroesophageal reflux disease prevalence, incidence, and frequency of complications (stricture/esophagitis/Barrett’s esophagus/ carcinoma) in Turkey compared to other geographical regions globally?

Bor

Yüksel

2017

Turk J Gastroenterol

View full text Add to dashboard Cite

Although many studies are conducted on gastroesophageal reflux disease (GERD) and its complications, the questionnaires and reflux definitions used in the studies are different. Mayo, GERD-Q, DIGEST-Q, RDQ, and various other questionnaires that were created and have been used in the studies. The GERD definition that is mostly accepted around the world is the presence of the complaints of heartburn and/or regurgitation at least once a week. However, many different definitions, such as the presence of heartburn and/or regurgitation at least twice a week or at least once a year (if once a week, "frequent"; if once a year, "rare") and the presence of heartburn and/or regurgitation without considering the frequency and severity, were all used in the studies. Therefore, it is quite difficult to obtain a single datum by collecting these studies. However, studies including all questionnaires and reflux definitions were considered while collecting this data.Another problem encountered while performing epidemiological scanning of GERD is that when the world was separated into two parts as the East and the West, some countries that were different from each other were included in the same group (such as Iran-China and Germany-Brazil). Even though continents are considered for this separation, countries that do not resemble each other from any perspective, such as Iran and China, were included in the same group. Therefore, groups must be formed according to the higher number of ethnic distributions. There are also regional epidemiological differences even in the same country. Moreover, there is no term equivalent to heartburn and regurgitation in some Eastern languages.Turkey is geographically located in the middle of the Eastern and Western countries and the epidemiology of GERD and its complications is similar to both geographical groups (Figure 1). In the Eastern countries, the prevalence of GERD is lower and regurgitation is predominant. On the other hand, in the Western countries, the prevalence of GERD is higher and heartburn is predominant. Considering the complications, erosive esophagitis, Barrett's esophagus, and associated esophageal adenocarcinoma are seen in the Western countries more commonly.In GERD epidemiological studies performed in Turkey, the Mayo questionnaire was mostly used (1, 2). The GERD-Q form was used in one study (3). The studies in which the Mayo questionnaire was used, found the prevalence of GERD as 20% (1), 19.3% (2), 12.5% (4), and 22.8% (5,6), respectively. In the study using the other question form, the prevalence of GERD was 24.7% (3). When 5 studies were evaluated cumulatively, the prevalence was calculated to be 23%. It was observed that regurgitation was predominant in all of the studies. In the cumulative evaluation, the rate of prevalence was 23% for regurgitation and 19% for heartburn.While the date of the publications on the epidemiology of GERD goes back to the 2000s in the countries to the east of Turkey, the first articles on this subject were written in 1990s in the Western cou...

show abstract

“…A recent study from the University of Chicago found a 150-fold increased prevalence of BE if goblet cells are not required for this diagnosis. 19 Balasubramanian et al, 20 studied 1058 patients with gastroesophageal reflux disease and found a prevalence of CLE on index endoscopy of 23.3%, whereas CLE with IM was found in only 14.1%. On multivariate analysis, heartburn duration for 45 years, Caucasian race and the presence of a hiatal hernia were found to be independent predictors for CLE, and CLE length was significantly associated with the presence of IM.…”

Section: The Evolving Definition Of Bementioning

confidence: 99%

Current issues in Barrett's esophagus and Barrett's-related dysplasia

Goldblum

2015

Modern Pathology

View full text Add to dashboard Cite

Prevalence and Predictors of Columnar Lined Esophagus in Gastroesophageal Reflux Disease (GERD) Patients undergoing upper endoscopy

Abstract: If BE is defined by the presence of CLE alone on upper endoscopy, up to 25% of GERD patients are diagnosed with this lesion. Enrolling all these patients in surveillance programs would have significant ramifications on health-care resources.

Cited by 61 publications

References 43 publications

Association between the Body Mass Index and the Risk of Barrett's Esophagus in Japan

Association between the Body Mass Index and the Risk of Barrett's Esophagus in Japan

How is the gastroesophageal reflux disease prevalence, incidence, and frequency of complications (stricture/esophagitis/Barrett’s esophagus/ carcinoma) in Turkey compared to other geographical regions globally?

Current issues in Barrett's esophagus and Barrett's-related dysplasia

Contact Info

Product

Resources

About