Prevalence and potential risk factors for the occurrence of cefotaxime resistant Escherichia coli in German fattening pig farms—A cross-sectional study

Hering, Johanna; Hille, Katja; Frömke, Cornelia; Münchhausen, Christiane von; Hartmann, Maria; Schneider, B.; Friese, Anika; Roesler, Uwe; Merle, Roswitha; Kreienbrock, Lothar

doi:10.1016/j.prevetmed.2014.06.014

Cited by 45 publications

(34 citation statements)

References 22 publications

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“…A recent cross-sectional study in Germany showed that some farm management and hygienic factors could be tackled to control cefotaxime resistant E . coli [21]. In our study, the set of selected determinants in the univariate analysis showed that apart of the restricted use of cephalosporins, additional measures focused on improving biosecurity and animal management measures could be an aid to control ESBL- E .…”

Section: Discussionmentioning

confidence: 85%

Risk factors for ESBL-producing Escherichia coli on pig farms: A longitudinal study in the context of reduced use of antimicrobials

et al. 2017

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The presence of extended-spectrum beta-lactamase-producing Escherichia coli (ESBL-E. coli) in food animals is a public health concern. This study aimed to determine prevalence of ESBL-E. coli on pig farms and to assess the effect of reducing veterinary antimicrobial use (AMU) and farm management practices on ESBL-E. coli occurrence on pig farms. During 2011–2013, 36 Dutch conventional pig farms participated in a longitudinal study (4 sampling times in 18 months). Rectal swabs were taken from 60 pigs per farm and pooled per 6 pigs within the same age category. Presence of ESBL-E. coli was determined by selective plating and ESBL genes were characterized by microarray, PCR and gene sequencing. An extensive questionnaire on farm characteristics and AMU as Defined Daily Dosages per Animal Year (DDDA/Y) was available for the 6-month periods before each sampling moment. Associations between the presence of ESBL-E. coli-positive pigs and farm management practices were modelled with logistic regression. The number of farms with ESBL-E. coli carrying pigs decreased from 16 to 10 and the prevalence of ESBL-E. coli-positive pooled pig samples halved from 27% to 13%. Overall, the most detected ESBL genes were blaCTX-M-1, blaTEM-52 and blaCTX-M-14. The presence of ESBL-E. coli carrying pigs was not related to total AMU, but it was strongly determined by the presence or absence of cephalosporin use at the farm (OR = 46.4, p = 0.006). Other farm management factors, related with improved biosecurity, were also plausibly related to lower probabilities for ESBL-E. coli-positive farms (e.g. presence of a hygiene lock, pest control delivered by a professional). In conclusion, ESBL-E. coli prevalence decreased in pigs during 2011 and 2013 in the Netherlands. On pig farms, the use of cephalosporins was associated with the presence of ESBL-E. coli carrying pigs.

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Section: Discussionmentioning

confidence: 85%

Risk factors for ESBL-producing Escherichia coli on pig farms: A longitudinal study in the context of reduced use of antimicrobials

et al. 2017

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“…However, according to Hering et al, few fecal samples were sufficient to determine the prevalence of cefotaxime-resistant E. coli for risk factor analysis in pig farms. 31 In contradiction, Dunlop et al found a positive link between herd size and carbadox resistance in farrow-to-finish herds with up to 150 and more sows. 20 Moreover, herd size and AMU were also reported to be positively associated, even though to some extent they were described as being indirectly associated through biosecurity.…”

Section: Farm/herd Managementmentioning

confidence: 97%

“…10,17,25 Moreover, the study of risk factors for cefotaxime resistance conducted by Hering et al found hygiene (related) measures such as separation of sick pigs, ventilation location, fly control, disinfection, and stable-assigned clothes to be associated with significantly increased AMR. 31 (This study did not fulfill the eligibility criteria of the search procedure and was therefore not included in the final review list).…”

Section: Burow and Kä Sbohrermentioning

confidence: 99%

Risk Factors for Antimicrobial Resistance in Escherichia coli in Pigs Receiving Oral Antimicrobial Treatment: A Systematic Review

Burow

Käsbohrer

2017

Microbial Drug Resistance

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The aim of this literature review was to identify risk factors in addition to antimicrobial treatment for antimicrobial resistance (AMR) occurrence in commensal Escherichia coli in pigs. A variety of studies were searched in 2014 and 2015. Studies identified as potentially relevant were assessed against eligibility criteria such as observation or experiment (no review), presentation of risk factors in addition to (single dosage) antimicrobial use, risk factors for but not resulting from AMR, and the same antimicrobial used and tested. Thirteen articles (nine on observational, four on experimental studies) were finally selected as relevant. It was reported that space allowance, production size/stage, cleanliness, entry of animals and humans into herds, dosage/frequency/route of administration, time span between treatment and sampling date, herd size, distance to another farm, coldness, and season had an impact on AMR occurrence. Associations were shown by one to four studies per factor and differed in magnitude, direction, and level of significance. The risk of bias was unclear in nearly half of the information of observational studies and in most of the information from experimental studies. Further research on the effects of specific management practices is needed to develop well-founded management advice.

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“…In addition, a correlation between the frequency of treatment and the occurrence of multidrug-resistant bacteria in animals has been demonstrated. The higher the treatment frequency (the average number of days each animal in the herd is treated with antibiotics), the higher the rate of resistance identified in isolates from animal products [23]. Thus, the use of antibiotics in both the health care system and in livestock production may promote dissemination of resistance genes as a direct consequence of selective pressure [24], [25], [26].…”

Section: Acquisition and Spread Of Antibiotic Resistance In Gram-nementioning

confidence: 99%

Antibiotic resistance: What is so special about multidrug-resistant Gram-negative bacteria?

Exner

Bhattacharya

Christiansen

et al. 2017

GMS Hygiene and Infection Control; 12:Doc05

187

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Prevalence and potential risk factors for the occurrence of cefotaxime resistant Escherichia coli in German fattening pig farms—A cross-sectional study

Cited by 45 publications

References 22 publications

Risk factors for ESBL-producing Escherichia coli on pig farms: A longitudinal study in the context of reduced use of antimicrobials

Risk factors for ESBL-producing Escherichia coli on pig farms: A longitudinal study in the context of reduced use of antimicrobials

Risk Factors for Antimicrobial Resistance in Escherichia coli in Pigs Receiving Oral Antimicrobial Treatment: A Systematic Review

Antibiotic resistance: What is so special about multidrug-resistant Gram-negative bacteria?

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