Prevalence and potential relevance of hyperuricemia in pediatric kidney transplant recipients—a CERTAIN registry analysis

Ehren, Rasmus; Habbig, Sandra; Krupka, Kai; Ernst, Angela; Bald, Martin; König, Sabine; Murer, Luisa; Özçakar, Z. Bı̇rsı̇n; Pohl, Michael; Babenko, Nadezhda; Spartà, Giuseppina; Staude, Hagen; Strologo, Luca Dello; Szabó, Attila; Tönshoff, Burkhard; Weber, Lutz T.

doi:10.1111/petr.14265

Cited by 2 publications

(2 citation statements)

References 78 publications

(153 reference statements)

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“…A recent analysis of a multicenter pediatric kidney transplant database from Germany also found an inverse relationship between graft function and serum uric acid levels. The follow‐up time was five years, and although our follow‐up period was less extensive, the authors also find an inverse significant ( p = .026) association of serum uric acid levels with eGFR (the lower the eGFR, the higher the serum uric acid level) After five years, posttransplant, eGFR was significantly lower in the two groups with higher uric acid level ( p = .047 and p = .004, respectively) when compared with the group with lower uric acid level 17 …”

Section: Discussionmentioning

confidence: 66%

Serum uric acid concentration is associated with lower glomerular filtration rate in children undergoing kidney transplantation

Seibert,

Pereira,

Pestana

et al. 2024

Pediatric Transplantation

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BackgroundThe relationship between serum concentration of uric acid (UA) and chronic kidney disease is complex due to many confounding variables. There is currently debate over whether hyperuricemia acts as a marker of kidney disease or as an independent risk factor.ObjectivesTo test the impact of serum UA concentration on the estimated glomerular filtration rate (GFR) of children undergoing kidney transplantation.Patients and MethodsProspective longitudinal study of children and adolescents after kidney transplantation. We analyzed clinical, anthropometric, and laboratory data at pre‐transplant and 1, 3, and 6 months after transplant. We developed models of repeated measures analysis, using the generalized estimating equations technique for the outcome evolution of the estimated GFR at 1, 3 and 6 months. High serum UA concentration at 1 and 3 months was modeled as the main exposure variable.ResultsWe included 103 transplant patients. In a model adjusted for time, recipient sex and age, the occurrence of acute rejection episodes, and the estimated glomerular filtration at baseline, the trajectory of GFR exhibited an inverse relationship with UA (β = −7.1, 95% CI: −11.5 to −2.6, p < .01).ConclusionSerum UA increase was associated with lower graft function over time.

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Section: Discussionmentioning

confidence: 66%

Serum uric acid concentration is associated with lower glomerular filtration rate in children undergoing kidney transplantation

Seibert,

Pereira,

Pestana

et al. 2024

Pediatric Transplantation

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“…While there are challenges with preoperative matching, operation protocol, and long-term care after surgery, a few transplant centers have been exploring the rational utilization of pediatric donor kidneys. Many donor and recipient factors, such as donor type, pre-transplant weight status, donorrecipient size matching, blood type, hyperuricemia, hyper-filtration injury and primary disease have been found affecting renal allograft survival in different studies (19)(20)(21)(22)(23). However, risk factors of kidney transplantation from pediatric deceased donors have not been well explored.…”

Section: Introductionmentioning

confidence: 99%

Single kidney transplantation from pediatric deceased donors in China: the outcomes and risk factors of graft survival

Huang¹,

Wu²,

Zhang³

et al. 2022

Transl Pediatr

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Background: Pediatric deceased donors offer great potential for expanding the organ donor pool. The utilization of pediatric donor kidneys has been explored by numerous transplant centers; however, the transplant outcome and risk factors have not been well elucidated. The aim of this study was to demonstrate the safety and risk factors of transplant outcome from pediatric deceased donors.Methods: We retrospectively analyzed 484 cases of single kidney transplantation (SKT) with pediatric donor kidneys performed at our center from January 2012 to March 2021. The recipients were grouped by age: child (≤12 years; n=143), adolescents (12-18 years; n=86), and adults (≥18 years; n=255). The overall prognosis of the recipients was analyzed, and the post-transplant outcomes were compared among the three groups and assessed by univariate and multivariate analyses using the Cox proportional risk model. Results:The median follow-up time was 26.7 months. The 1-and 3-year patient survival rates were 98.7% and 96.8%, respectively. The 1-and 3-year death-censored graft survival (DCGS) was 96.1% and 92.7%, respectively. The overall estimated glomerular filtration rates (eGFRs) at 1 and 3 years were 80.0±24.5 and 84.2±25.2 mL/min/1.73 m 2 ; the 3-year eGFR of the three groups were comparable and all were over 80 mL/min/1.73 m 2 . Rejection was an independent risk factor for death-censored graft failure within 3 years after transplantation [hazard ratio (HR) =3.85; P=0.001], and was the primary cause of graft losses in the adolescent group. Thrombosis was more common within 1-month post-transplant in the child recipients (P<0.05), and its incidence was higher in recipients with donor body weight (DBW) ≤11 kg.Conclusions: SKT from pediatric donors could achieve decent outcomes. Rejection was an independent risk factor of graft survival, especially for adolescent recipients. Child recipients may compromise early transplant outcomes due to vascular thrombosis, which might be related to small (DBW ≤11 kg) pediatric donors.

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Prevalence and potential relevance of hyperuricemia in pediatric kidney transplant recipients—a CERTAIN registry analysis

Cited by 2 publications

References 78 publications

Serum uric acid concentration is associated with lower glomerular filtration rate in children undergoing kidney transplantation

Serum uric acid concentration is associated with lower glomerular filtration rate in children undergoing kidney transplantation

Single kidney transplantation from pediatric deceased donors in China: the outcomes and risk factors of graft survival

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