Prevalence and Polysomnographic Correlates of Insomnia Comorbid with Medical Disorders

Budhiraja, Rohit; Roth, Thomas; Hudgel, David W.; Budhiraja, Pooja; Drake, Christopher L.

doi:10.5665/sleep.1114

Cited by 218 publications

(174 citation statements)

References 46 publications

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“…Schlafmangel, aber auch eine erhöhte Schlafdauer (Hypersomnie), sind mit einem erhöhten Risiko für eine Vielzahl psychischer und somatischer Gesundheitsstörungen verbunden [3,8,9]. So haben beispielsweise sowohl "Kurz-" als auch "Lang"-Schläfer eine deutlich erhöhte Mortalität gegenüber "Normal"-Schläfern [3].…”

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Häufigkeit und Verteilung von Schlafproblemen und Insomnie in der deutschen Erwachsenenbevölkerung

Schlack

Hapke

Maske

et al. 2013

Bundesgesundheitsbl.

176

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Häufigkeit und Verteilung von Schlafproblemen und Insomnie in der deutschen Erwachsenenbevölkerung

Schlack

Hapke

Maske

et al. 2013

Bundesgesundheitsbl.

176

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“…12 Moreover, some disturbances during sleep cause cardiovascular diseases, 13 behavioral disturbances, depression 14 and anxiety. 15 Reduction of general health, pain and negative effects on quality of life are common in RA, 16 however fewer researches have been done on sleep disorders of patients with RA. Although new methods for RA have been presented with new medical technology, but there have not been significant outcomes in solving the psychosocial and sleep problems of these patients.…”

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confidence: 99%

Relationship between Sleep Disorders, Pain and Quality of Life in Patients with Rheumatoid Arthritis

et al. 2015

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“…These observations are supported by research findings in the literature. 25 In this large community-based cross-sectional study, the odds of insomnia was higher in people with diabetes (OR, 1.4; 95 % CI, 1.05 − 2.0; p = 0.04). 25 A previous epidemiologic cohort study linked insomnia with self-reported rheumatoid arthritis in a large population-based prospective study in Norwegian people, which showed an OR of 1.87 (95 % CI, 1.29-2.52).…”

Section: Discussionmentioning

confidence: 80%

Risk of Autoimmune Disease in Adults with Chronic Insomnia Requiring Sleep-Inducing Pills: A Population-Based Longitudinal Study

et al. 2016

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BACKGROUND: Recent studies indicate that chronic insomnia is associated with the development of certain somatic diseases. Whether it would be associated with the development of an autoimmune disease (AID) was unknown. OBJECTIVE: We aimed to examine the association and quantify the magnitude of risk for AID in individuals suffering from chronic insomnia requiring sleep-inducing pills. DESIGN: This was a population-based, nationwide longitudinal study. PARTICIPANTS: Using a claims data set containing 1 million randomly sampled, insured subjects derived from the National Health Insurance Research Database, we assembled a chronic insomnia group and a 1:3 propensity score-matched comparison group (CP), which were balanced in terms of sex, age, insurance premium, urbanization, alcohol use disorder, smoking-related diagnoses, and morbid obesity. MAIN MEASURES: Person-time data with incidence rate, adjusted hazard ratios (aHR) by the Cox model, AID-free survival functions compared with the log-rank test, and a sensitivity analysis on the time lag effect were presented. Incident AID within the first year of follow-up were excluded. The error rate was controlled using the BenjaminiHochberg procedure. KEY RESULTS: With 39,550 and 129,914 person-years' follow-up for the chronic insomnia and CP groups (n = 5,736 and 17,208), respectively, we found an increased risk for subsequent AID, representing a 70 % increase in the aHR (1.7; 95 % confidence interval [CI], 1.5-1.9, p < 0.0001). A positive association between chronic insomnia and primary Sjögren's syndrome (pSS) was observed (aHR, 1.3; 95 % CI, 1.1-1.6). Sensitivity analysis disclosed that AID risk was even stronger after 5 years of follow-up (aHR, 2.0; 95 % CI, 1.7-2.4). CONCLUSION:Chronic insomnia requiring sleepinducing pills may be associated with a 70 % increased risk for future AID, particularly pSS.KEY WORDS: chronic insomnia; autoimmune disease; population-based study; propensity score matching; Sjögren's syndrome.

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Prevalence and Polysomnographic Correlates of Insomnia Comorbid with Medical Disorders

Abstract: This large population-based study suggests that insomnia is highly prevalent in diverse chronic medical disorders. However, polysomnographic evidence of disturbed sleep is present in only a subset of comorbid insomnia populations.

Cited by 218 publications

References 46 publications

Häufigkeit und Verteilung von Schlafproblemen und Insomnie in der deutschen Erwachsenenbevölkerung

Häufigkeit und Verteilung von Schlafproblemen und Insomnie in der deutschen Erwachsenenbevölkerung

Relationship between Sleep Disorders, Pain and Quality of Life in Patients with Rheumatoid Arthritis

Risk of Autoimmune Disease in Adults with Chronic Insomnia Requiring Sleep-Inducing Pills: A Population-Based Longitudinal Study

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