Prevalence and patterns of anti‐epileptic medication prescribing in the treatment of epilepsy in older adults with intellectual disabilities

O'Dwyer, Máire; Peklar, Jure; Mulryan, Niamh; McCallion, Philip; McCarron, Mary; Henman, Martin

doi:10.1111/jir.12461

Cited by 16 publications

(17 citation statements)

References 65 publications

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“…It should be noted that adverse cardiovascular effects from antipsychotic drugs are common, highlighting the current findings of low prevalence of drug use for the cardiovascular system in the higher age categories in the ID sample . Also, the prevalence of anxiolytic drug use was higher in the ID sample when compared with the reference sample and is in accordance with the findings in Doan et al The prevalence of antiepileptic drug use in the ID sample was also in line with previous findings and the reported prevalence of epilepsy in people with IDs . Thus, it can be suggested that epilepsy is adequately identified and treated at an age‐independent group level.…”

Section: Discussionsupporting

confidence: 89%

“…27 Also, the prevalence of anxiolytic drug use was higher in the ID sample when compared with the reference sample and is in accordance with the findings in Doan et al 11 The prevalence of antiepileptic drug use in the ID sample was also in line with previous findings and the reported prevalence of epilepsy in people with IDs. 28,29 Thus, it can be suggested that epilepsy is adequately identified and treated at an age-independent group level.…”

Section: Figurementioning

confidence: 99%

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Prevalence of drug use among adults with intellectual disabilities compared with drug use in the general population

Hove¹,

Biringer²,

Havik

et al. 2019

Pharmacoepidemiology and Drug

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Purpose Individuals with intellectual disabilities (IDs) have more health problems, a poorer general health, and a shorter life expectancy than individuals in general. High rates of drug use in IDs have been reported. Despite the increasing interest in health problems in individuals with IDs, little is known about their drug use. Method Drug use in a community sample of adults with IDs (N = 593) was compared with dispensed drugs in a time‐, age‐, and region‐matched comparison group of adults in Western Norway (N = 289 325). A logistic regression model was employed by using the main group effect to describe and analyze the differences between the ID sample and the comparison sample and by using the interaction term (group × age) to describe the rate change differences from the reference age (18‐30 years) between the two groups. Results Total drug use in the ID sample was 62% compared with 50% in the reference sample (P = 0.0001). The high prevalence of drugs for the nervous system (ATC N) in the ID sample (50%) explained the difference. From age 51 and over, the increase in the drug use rate for the cardiovascular disease was significantly lower in the ID sample than in the reference sample (P value range: 0.002‐0.019). Conclusions Adults with IDs use more drugs than adults in general. However, the findings showed lower rates of drug use in the ID sample than in the general population for drugs targeting diseases that are the leading causes of death in individuals with IDs.

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Section: Discussionsupporting

confidence: 89%

Section: Figurementioning

confidence: 99%

Prevalence of drug use among adults with intellectual disabilities compared with drug use in the general population

Hove¹,

Biringer²,

Havik

et al. 2019

Pharmacoepidemiology and Drug

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“…This is (or was) the case in the UK according to a 2003 survey [115]. In a more recent Irish survey of 736 older adults with intellectual disabilities, the most prescribed drugs were valproic acid (48.7%) and CBZ (46.3%), followed by lamotrigine (27.8%) [116]. Recommendations in terms of careful CBZ dosing and serum monitoring is thus especially valuable in this population [115].…”

Section: Elderly Patientsmentioning

confidence: 99%

Current role of carbamazepine and oxcarbazepine in the management of epilepsy

Beydoun

Dupont

Zhou

et al. 2020

Seizure

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“…Pada sebuah studi yang dilakukan pada pasien disabilitas intelektual dewasa dengan epilepsi, penggunaan antiepilepsi yang paling sering dilaporkan adalah asam valproat (48,7%), karbamazepin (46,3%) dan lamotrigin (27,8%). 31 Pada tahun 2017, terdapat penggunaan donepezil yang langsung masuk ke dalam segmen DU 90% (dapat dilihat pada Tabel 3). Donepezil (N06DA02) merupakan obat antidemensia dan antikolinesterase.…”

Section: Pembahasanunclassified

Analisis Minimalisasi Biaya Penggunaan Psikotropika pada Pasien Remaja dengan Disabilitas Intelektual di Rumah Sakit Jiwa Provinsi Jawa Barat Tahun 2015–2017

Nur

Zakiyah

Suwantika

2018

ijcp

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AbstrakObat-obatan psikotropika merupakan obat-obatan yang paling banyak digunakan pada pasien remaja dengan disabilitas intelektual di Rumah Sakit Jiwa Provinsi Jawa Barat. Penelitian farmakoekonomi pada topik ini penting dilakukan karena adanya peningkatan kebutuhan anggaran obat-obatan psikotropika sementara anggaran yang tersedia masih terbatas. Tujuan penelitian ini adalah untuk mengetahui profil penggunaan obat-obatan psikotropika pada pasien remaja dengan disabilitas intelektual di rumah sakit tersebut pada kurun waktu tahun 2015-2017 dan untuk mengetahui biaya obat-obatan psikotropika yang paling rendah pada segmen drug utilization 90% (DU 90%) pada tahun-tahun tersebut. Studi observasional deskriptif secara retrospektif dan prospektif dilakukan untuk mengumpulkan data dari rekam medik. Metode Anatomical Therapeutic Chemical Classification with Defined Daily Dose (ATC/DDD) dan Analisis Minimalisasi Biaya (AMiB) digunakan untuk mengetahui profil penggunaan obat-obatan dan untuk menganalisis biaya obat-obatan yang paling rendah selama kurun waktu tersebut. Pada penelitian ini, terdapat penggunaan 33 jenis obat psikotropika (19 jenis pada tahun 2015, 22 jenis pada tahun 2016 dan 29 jenis pada tahun 2017). Cost of DU 90% pada tahun 2015-2017 secara berurutan yaitu 55,11%, 68,73% dan 93,81%, sedangkan cost/DDD segmen DU 90% secara berurutan yaitu Rp6.258, Rp7.447, dan Rp8.803. Biaya obat-obatan psikotropika pada tahun 2015 merupakan biaya terendah selama 2015-2017. AbstractPsychotropic drugs were one of the the most widely used drugs in adolescent patients with intellectual disability in Mental Hospital of West Java. Pharmacoeconomic study on this topic is important because budget for psychotropic drugs need is increased while the available budget is still limited. The objective of this study was to analyze the utilization profile of psychotropic drugs in adolescents with intellectual disability during a time horizon of 2015-2017 and to investigate the lowest cost of psychotropic drugs in a segment of drug utilization 90% (DU 90%) during those years. Retrospective and prospective observational studies were applied to collect patients' medical record data. The Anatomical Therapeutic Chemical Classification System with Defined Daily Dose (ATC/DDD) and Cost Minimization Analysis (CMA) methods were applied to analyse the utilization profile of drugs and to investigate the lowest cost of drugs during the time horizon, respectively. In this study, there were 33 types of psychotropic drugs used (19 types in 2015, 22 types in 2016, and 29 types in 2017). The costs of DU 90% during 2015-2017 were estimated to be 55.11%, 68.73% and 93.81% in 2015, 2016 and 2017, respectively, while the costs per DDD in DU 90% segment were estimated to be IDR 6,258, IDR 7,447, and IDR 8,803, respectively. In particular, cost of psychotropic drugs in 2015 was considered to be the lowest cost during 2015-2017.

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Prevalence and patterns of anti‐epileptic medication prescribing in the treatment of epilepsy in older adults with intellectual disabilities

Cited by 16 publications

References 65 publications

Prevalence of drug use among adults with intellectual disabilities compared with drug use in the general population

Prevalence of drug use among adults with intellectual disabilities compared with drug use in the general population

Current role of carbamazepine and oxcarbazepine in the management of epilepsy

Analisis Minimalisasi Biaya Penggunaan Psikotropika pada Pasien Remaja dengan Disabilitas Intelektual di Rumah Sakit Jiwa Provinsi Jawa Barat Tahun 2015–2017

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