Prevalence and outcomes of acute kidney injury in term neonates with perinatal asphyxia

Dan, Alaro; Admani, Bashir; Musoke, Rachel; Wanaiana, Lucy

doi:10.4314/ahs.v14i3.26

Cited by 74 publications

(63 citation statements)

References 11 publications

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“…Kaur et al [38] reported an AKI incidence of 41.7% in asphyxiated neonates, with an incidence of 9.1% in infants with moderate asphyxia and 56% among infants with severe asphyxia. Other studies support the correlation of AKI incidence with advancing severity of hypoxic ischemic encephalopathy [39,40] (Table 2). Newborns with congenital heart diseases affecting systemic circulation, and especially those undergoing cardiopulmonary bypass, also have higher incidences of AKI than the baseline neonatal population [41,42].…”

Section: Groups At High Risk Of Developing Aki In the Neonatal Periodsupporting

confidence: 59%

Acute kidney injury in the fetus and neonate

Nada

Bonachea

Askenazi

2017

Seminars in Fetal and Neonatal Medicine

136

105

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SUMMARY Acute kidney injury (AKI) is an under-recognized morbidity of neonates; the incidence remains unclear due to the absence of a unified definition of AKI in this population and because previous studies have varied greatly in screening for AKI with serum creatinine and urine output assessments. Premature infants may be born with less than half of the nephrons compared with term neonates, predisposing them to chronic kidney disease (CKD) early on in life and as they age. AKI can also lead to CKD, and premature infants with AKI may be at very high risk for long-term kidney problems. AKI in neonates is often multifactorial and may result from prenatal, perinatal, or postnatal insults as well as any combination thereof. This review focuses on the causes of AKI, the importance of early detection, the management of AKI in neonates, and long-term sequela of AKI in neonates.

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Section: Groups At High Risk Of Developing Aki In the Neonatal Periodsupporting

confidence: 59%

Acute kidney injury in the fetus and neonate

Nada

Bonachea

Askenazi

2017

Seminars in Fetal and Neonatal Medicine

136

105

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“…Of these 260 study cases, 139 (53.5 %) were male patients while 121 (46.5 %) were female patients. A study conducted in Kenya by Alaro et al 12 has also reported 60 % male gender predominance which is close to our study results. A study conducted by Medani et al 13 from Sudan has also reported 59 % male gender predominance which is similar to that of our study results.…”

Section: Discussion;supporting

confidence: 92%

“…The incidence of asphyxia is estimated to be between 1 and 8 per 1000 live births. This wide range can be largely attributed to problems in selecting indicators to identify children with perinatal asphyxia 12,13 .…”

Section: Discussion;mentioning

confidence: 99%

Role of Magnesium Sulphate in Newborns With Birth Asphyxia.

2019

JMPB

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Background; Birth asphyxia is a leading cause of mortality and morbidity in neonates in developing countries, with an incidence of 100-250/1000 live births compared to 5-10/1000 live births in the developed world. It remains a significant cause of loss of life and adverse developmental outcome. Objective; To compare magnesium sulphate therapy versus placebo in control of fits among newborns admitted with birth asphyxia along with fits at a tertiary care hospital. Material and Methods; All the study (n=260) participants of either sex who met inclusion of this study were who are admitted with birth asphyxia. Group A was study group and was treated with magnesium sulfate in a dose of 250 mg/kg initially within six hours of birth followed by 250 mg/kg at 24 and 48 h of birth while group B (control group) was not given MgSO4 therapy and were observed for control of fits and was given standard treatment. Results; Of these 260 study cases, 139 (53.5 %) were male patients while 121 (46.5 %) were female patients. Mean age of our study cases was 3.84 ± 1.47 hours. Of these 260 study cases, 177 (68.1%) belonged to rural areas and 83 (31.9 %) belonged to urban areas. Of these 260 study cases, home delivery was noted in 91 (35.0%), 149 (57.3%) in private clinics / hospital and 20 (7.7%) in teaching hospital. Mean gestational age of our study cases was 38.23 ± 2.38 and preterm births were noted in 91 (35.0%) of our study cases. Of these 260 study cases, control of fits were noted in 173 (66.5%) while control of fits in group A were noted in 105 (80.8%) and in group B it was 68 (52.3%) (p = 0.000). Conclusion; Our study results support the use of Magnesium Sulphate in control of fits in children with birth asphyxia. Magnesium sulphate was safe, reliable and having no side effect so it can be used safely in these patients to reduce morbidity and mortality. All clinicians treating such patients can employ this treatment modality having safety and efficacy.

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“…After 24 h, the supernatant containing non-adherent cells was removed and fresh medium was added. The medium was changed every 3–5 days, after the cells had grown to near confluence and the density was approximately (4–5)×10 5 cells/cm 2 ; the cells were passaged 3 times and the suspended cells were discarded. Subsequently, the pure adherent cells (BMSCs) were cultivated for further analysis.…”

Section: Methodsmentioning

confidence: 99%

Microarray expression profiles of genes in lung tissues of rats subjected to focal cerebral ischemia-induced lung injury following bone marrow-derived mesenchymal stem cell transplantation

Xiong

Zhang

et al. 2016

International Journal of Molecular Medicine

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Ischemia-induced stroke is the most common disease of the nervous system and is associated with a high mortality rate worldwide. Cerebral ischemia may lead to remote organ dysfunction, particular in the lungs, resulting in lung injury. Nowadays, bone marrow-derived mesenchymal stem cells (BMSCs) are widely studied in clinical trials as they may provide an effective solution to the treatment of neurological and cardiac diseases; however, the underlying molecular mechanisms remain unknown. In this study, a model of permanent focal cerebral ischemia-induced lung injury was successfully established and confirmed by neurological evaluation and lung injury scores. We demonstrated that the transplantation of BMSCs (passage 3) via the tail vein into the lung tissues attenuated lung injury. In order to elucidate the underlying molecular mechanisms, we analyzed the gene expression profiles in lung tissues from the rats with focal cerebral ischemia and transplanted with BMSCs using a Gene microarray. Moreover, the Gene Ontology database was employed to determine gene function. We found that the phosphoinositide 3-kinase (PI3K)-AKT signaling pathway, transforming growth factor-β (TGF-β) and platelet-derived growth factor (PDGF) were downregulated in the BMSC transplantation groups, compared with the control group. These results suggested that BMSC transplantation may attenuate lung injury following focal cerebral ischemia and that this effect is associated with the downregulation of TGF-β, PDGF and the PI3K-AKT pathway.

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Prevalence and outcomes of acute kidney injury in term neonates with perinatal asphyxia

Cited by 74 publications

References 11 publications

Acute kidney injury in the fetus and neonate

Acute kidney injury in the fetus and neonate

Role of Magnesium Sulphate in Newborns With Birth Asphyxia.

Microarray expression profiles of genes in lung tissues of rats subjected to focal cerebral ischemia-induced lung injury following bone marrow-derived mesenchymal stem cell transplantation

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