Prevalence and outcome of pregnancies in Norwegian and Swedish women with cystic fibrosis

Ødegaard, Inger; Stray‐Pedersen, Babill; Hallberg, Karin; Haanaes, Ole Christen; Storrøsten, Olav Trond; Johannesson, Marie

doi:10.1034/j.1600-0412.2002.810802.x

Cited by 16 publications

(5 citation statements)

References 23 publications

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“…Pregnancy risk in patients with cystic fibrosis who have not received a transplant correlates with disease severity; the same correlation should apply to cystic fibrosis patients who are transplant recipients as well. [22][23][24][25][26][27][28] When recipients who received a transplant because of cystic fibrosis (12 pregnancies) are compared with recipients who received a transplant for other reasons (18 pregnancies), recipients with cystic fibrosis have a mean interval from transplant to conception that is shorter by more than a year and a higher incidence of rejection during pregnancy (25% in recipients with cystic fibrosis, 11% in others). The rates of spontaneous abortion (25% in recipients with cystic fibrosis, 33% in others) and of live births (58% in recipients with cystic fibrosis, 61% in others) are similar.…”

Section: Discussionmentioning

confidence: 99%

Pregnancy after Lung Transplant

et al. 2012

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The purpose of this study was to analyze pregnancy outcomes in female lung transplant recipients. Data were collected from the National Transplantation Pregnancy Registry via questionnaires, interviews, and hospital records. Twenty-one female lung recipients reported 30 pregnancies with 32 outcomes (1 triplet pregnancy). Outcomes included 18 live births, 5 therapeutic abortions, and 9 spontaneous abortions. No stillbirths or ectopic pregnancies were reported. Mean (SD) interval from transplant to conception was 3.6 (3.3) years (range, 0.1-11.3 years). Comorbid conditions during pregnancy included hypertension in 16, infections in 7, diabetes in 7, preeclampsia in 1, and rejection in 5 women. Ten of the 21 recipients received a transplant because of cystic fibrosis and accounted for 12 pregnancy outcomes (7 live births, 3 spontaneous abortions, and 2 therapeutic abortions). At last recipient contact, 13 had adequate function, 2 had reduced function, 5 recipients had died (2 with cystic fibrosis), and 1 recipient had a nonfunctioning transplant. Mean gestational age of the newborn was 33.9 (SD, 5.2) weeks, and 11 were born preterm (<37 weeks). Mean birthweight was 2206 (SD, 936) g and 11 were low birthweight (<2500 g). Two neonatal deaths were associated with a triplet pregnancy; one fetus spontaneously aborted at 14 weeks and 2 died after preterm birth at 22 weeks. At last follow-up, all 16 surviving children were reported healthy and developing well. Successful pregnancy is possible after lung transplant, even among recipients with a diagnosis of cystic fibrosis.

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Section: Discussionmentioning

confidence: 99%

Pregnancy after Lung Transplant

et al. 2012

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“…Histologic abnormalities of the cervix associated with CF have received relatively little attention. However, it is known that women with CF have abnormally thick, dehydrated cervical mucus, which may contribute to infertility and hypofertility in some patients (1)(2)(3)(4)(5)(6).…”

Section: Discussionmentioning

confidence: 99%

Cystic Fibrosis Involving the Cervix, Mimicking a Well-differentiated Adenocarcinoma

Previs¹,

Edwards²,

Secord³

et al. 2014

International Journal of Gynecological Pathology

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We describe clinicopathologic and immunohistochemical features of an unusual case of cystic fibrosis manifesting in the cervix as a mass lesion, mimicking cervical adenocarcinoma. A 24-year-old nulligravida with cystic fibrosis developed heavy postcoital vaginal bleeding 4 months after starting oral contraceptives and was found to have a cervical mass. She underwent a loop electrosurgical excision of the mass, and microscopic examination revealed a florid endocervical proliferation, extending to the margins. This lesion was initially interpreted as an invasive, well-differentiated endocervical adenocarcinoma. However, on subsequent review, the lesion was found to have a low rate of proliferation, no evidence of an infiltrative growth pattern, and abundant acute inflammation. Given these findings and the absence of any residual endocervical lesion on a subsequent cold knife conization, we determined that this was a benign, likely reactive, lesion. This case, together with previous studies, suggests that women with cystic fibrosis can develop proliferative endocervical lesions and that oral contraceptives may contribute to their development.

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“…Subfertility is seen in animal models of CF as well: mice with CFTR gene mutations have fewer pregnancies and fewer offspring per pregnancy; 29% experienced infertility over a 5-month study period [47] . While females with CF attempt pregnancy at lower rates than in the general population (40% in a retrospective study of 605 patients), one-third of those who do experience infertility [48] , [49] ( Fig. 2 ).…”

Section: Fertility Among Females With Cfmentioning

confidence: 99%