Prevalence and outcome of asymptomatic bacteriuria in early pregnancy

Radha, Sreekumary; Nambisan, Bindu; Prabhakaran, N; Jamal, Shahida

doi:10.18203/2320-1770.ijrcog20164663

Cited by 16 publications

(25 citation statements)

References 7 publications

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“…The women of LD group had 14 times greater Odds of developing UTI in pregnancy when compared to ED group in the present study. Not only that, previous history of UTI was shown as a definite risk factor for ASB by Tahir S et al 23 The present study shows that women in LD group had 6.9 times greater Odds of developing gestational HTN or Preeclampsia similar to the findings of Radha S et al and Yu FN et al 21,24 However, no case of Gestational HTN or Preeclampsia was noted by Nkwabong E et al in their study. 25 No case of acute pyelonephritis occurred in any of the three groups in the present study.…”

Section: Discussionsupporting

confidence: 81%

“…20 A lower prevalence rate of 8.4% and 8.25% was obtained in a study by Lavanya SV et al and Radha S et al respectively. 10,21 This may be because most of the patients in our study were rural women with lower level of education and socioeconomic status. Jain V et al and Paari P et al observed a higher prevalence of 16.9% and 21.1% respectively.…”

Section: Discussionmentioning

confidence: 86%

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Maternofetal outcome in early versus late detected asymptomatic bacteriuria of pregnancy

Guntoory¹,

Penmetsa²,

Rayapu³

et al. 2017

Int J Reprod Contracept Obstet Gynecol

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INTRODUCTIONUrinary tract infection is a common medical complication of pregnancy. Women are more susceptible than men due to short urethra and contamination of the urogenital tract with faecal flora due to the proximity of the urogenital tract to the anal canal. Bacteriuria during pregnancy may be classified as Asymptomatic bacteriuria (ASB), infection of the lower urinary tract (cystitis) and infection of the upper urinary tract (pyelonephritis). Pregnancy in itself is a risk factor for the development of urinary tract infection due to the anatomical, physiological and immunological changes that occur in pregnancy. 90% of pregnant women develop urethral dilatation starting by about 6 th week of pregnancy, increase in bladder volume, ABSTRACTBackground: Urinary tract infection in pregnancy is a problem of global significance. Untreated asymptomatic bacteriuria in pregnancy is known to be associated with maternal and foetal outcome in the form of symptomatic urinary tract infection (UTI), acute pyelonephritis, anaemia, pregnancy induced hypertension (PIH), preterm labour (PTL), low birth weight (LBW), intrauterine growth restriction (IUGR) and prematurity. This study is aimed to compare the maternal and foetal outcome of pregnant women with bacteriuria with that of women without bacteriuria and also to see if screening later in pregnancy at 28-37 weeks of gestation is as effective as screening at less than 20 weeks of pregnancy in terms of maternofoetal outcome. Methods: 165 pregnant women attending the antenatal clinic at MIMS, Nellimerla, Vizianagaram district, Andhra Pradesh, India were screened for asymptomatic bacteriuria by urine culture and sensitivity. They were grouped into asymptomatic bacteriuria negative and culture positive groups. Culture positives were further grouped as early detected and late detected group based on the gestational age at sampling. They were followed up till delivery. The maternofoetal outcome was compared between different groups by computing Odd's ratio and P value of less than 0.05 was taken as significant. Results: There was no statistically significant increase in adverse maternofoetal outcome between early detected and bacteriuria negative group. The women of late detected group had greater odds of developing symptomatic UTI, PIH, PTL, LBW, IUGR and neonatal intensive care unit admissions when compared to early detected and bacteriuria negative group which was statistically significant. Conclusions: Screening for asymptomatic bacteriuria early in pregnancy at less than 20 weeks is more effective in reducing the adverse maternofoetal outcome.

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Section: Discussionsupporting

confidence: 81%

Section: Discussionmentioning

confidence: 86%

Maternofetal outcome in early versus late detected asymptomatic bacteriuria of pregnancy

Guntoory¹,

Penmetsa²,

Rayapu³

et al. 2017

Int J Reprod Contracept Obstet Gynecol

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show abstract

“…E. coli is the most common isolate in ASB as it was also confirmed in a prospective study in Odisha state, India and in Abuja (56.%) [19][20][21][22][23]. CoNS is one of isolated uropathogens [25]. In another study CoNS was second most common (16.8%) after E. coli (58.96%) [26].…”

Section: Discussionmentioning

confidence: 55%

“…The bacteria were more susceptible to gentamycin, ceftriaxone and ciprofloxacin but resistant to nitrofurantoin and ampicillin. Nitrofurantoin is a widely recommended antibiotic for ASB treatment in pregnancy and it is associated with 80% cure rate with a 5 to 7 day course [15][16][17][18][19][20][21][22][23][24][25][26][27][28][29]. Suggested first line treatment include amoxil, nitrofurantoin and oral cephalosporins and gentamycin and ceftriaxone for staphylococcus and pseudomonas [30,31].…”

Section: Discussionmentioning

confidence: 99%

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2017

MOJI

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Background and objective: Effective treatment of asymptomatic bacteriuria in pregnancy requires susceptible drugs. The aim of this study was to determine antibiotic susceptibility pattern among isolated bacterial species among pregnant women with asymptomatic bacteriuria. Materials and Methods:This study was conducted at 4 selected primary health care facilities in Harare, including pregnant women registering for antenatal care at gestation between 6 and 22 weeks and without urinary tract infection symptoms. Asymptomatic bacteriuria was diagnosed by culture test of all midstream urine samples following screening by Griess nitrate test. Susceptibility test was done for all positive 24 hour old culture using the disk diffusion test. The minimum inhibitory concentration was measured and categorized as susceptible, resistant and intermediate.

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“…Similar results were claimed by Radha et al, where the incidence of preeclampsia was found to be 6.1%. 28 The higher incidence of preeclampsia in group I women can be attributed to increased maternal cytokines found in ASB may reflect vascular endothelial function which in turn leads to preeclampsia. 29 The incidence of anaemia was found to be high (14.7%) in group I pregnant women as compared to group II (4.5%).…”

Section: Discussionmentioning

confidence: 99%

Prevalence of asymptomatic bacteriuria among antenatal women and its effects on maternal and perinatal outcome in northern Andhra Pradesh population

et al. 2018

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INTRODUCTIONAsymptomatic bacteriuria (ASB) is a condition in which urine culture reveals a significant growth of pathogenic bacteria i.e. greater than 105 bacteria/mL without the presence of symptoms related to urinary tract infection (UTI).1 The pregnant women are more commonly affected than non-pregnant women due to various morphological, physiological changes and urinary stasis that occur during pregnancy due to the effect of progesterone. 2 The prevalence of ASB in pregnant women varies from 4% to 23.9% globally and the higher prevalence is attributed to lack of personal and environmental hygiene, socio-economic status, parity and ABSTRACT Background: The pregnant women are more commonly affected with asymptomatic bacteriuria (ASB) than nonpregnant women and its progression could lead to adverse maternal and perinatal outcomes. The study was designed with an aim to know the prevalence of ASB and its effects on maternal and perinatal outcome. Methods: In this prospective study, 300 antenatal women attending Anil Neerukonda Hospital were screened for ASB. Urine culture was performed using standardized Kirby-Bauer disc diffusion method on blood agar, Mac Conkey's agar for antibiotic sensitivity testing. The screened antenatal women were divided into two subgroups viz. asymptomatic bacteriuria positive (Group I) and asymptomatic bacteriuria negative (Group II) depending on the culture study and were followed till delivery for maternal and perinatal outcomes. Results: The prevalence of ASB was 11.33%. Out of 34 cases of ASB positive, 8 cases (23.5%) were delivered with birth weight <2500 grams as compared to 11 cases (4.1%) in unexposed cases (RR 5.68, 95% CI; 2.46-13.15; p<0.05). Preterm low birth was noticed in 5 (14.7%) cases of ASB positive pregnant women with compared to unexposed cases (RR 1.5, 95% CI; 0.61-3.65, p=0.36). Regarding maternal outcomes, premature labour was observed in 8 cases (23.5%) of ASB exposed women whereas 22 (8.3%) in non-exposed cases (RR 2.84, 95% CI; p=0.004). A significant number of women have developed hypertension (17.6%) and preeclampsia (8.8%) in ASB positive cases as compared to ASB negative cases (4.9% and 2.3% respectively). Conclusions: The prevalence of ASB was 11.33% in the present study. As one third of the cases were identified in early and late trimesters, regular and trimester wise screening need to be incorporated in routine antenatal screening for safe motherhood and new born health.

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Prevalence and outcome of asymptomatic bacteriuria in early pregnancy

Cited by 16 publications

References 7 publications

Maternofetal outcome in early versus late detected asymptomatic bacteriuria of pregnancy

Maternofetal outcome in early versus late detected asymptomatic bacteriuria of pregnancy

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Prevalence of asymptomatic bacteriuria among antenatal women and its effects on maternal and perinatal outcome in northern Andhra Pradesh population

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