Prevalence and outcome of acute gastrointestinal injury in critically ill patients

Zhang, Dong; Li, Yuting; Ding, Lili; Fu, Yao; Dong, Xianlin

doi:10.1097/md.0000000000012970

Cited by 45 publications

(37 citation statements)

References 22 publications

(31 reference statements)

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“…These children were signi cantly more severely ill (lower GCS scores and higher SOFA scores and PCISs) and exhibited greater morality than those without FI. The prevalence of FI was lower than that in previous studies on adult critically ill patients [17,18]. The reasons for this result are not clear.…”

Section: Discussioncontrasting

confidence: 82%

Gastrointestinal Failure Score in Children with Traumatic Brain Injury

Zhou

Lü

Tang³

2021

Preprint

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Purposes: To review the value of the gastrointestinal failure (GIF) score in children with different degrees of traumatic brain injury (TBI) by analyzing the correlation between outcome and gastrointestinal function. Methods: A total of 165 children with TBI who were diagnosed and treated in the surgical intensive care unit (SICU) for longer than 72 h between August 2017 and September 2019 were retrospectively analyzed. Admission parameters included sex, age, Glasgow Coma Scale (GCS) score, body mass index (BMI), leukocyte count, C-reactive protein (CRP), hemoglobin (Hb) and hematocrit (Hct), blood glucose, lactic acid, procalcitonin (PCT), albumin, plasma osmotic pressure, prothrombin time (PT) and activated partial thromboplastin time (APTT). To predict outcomes, the Sequential Organ Failure Assessment (SOFA) score, Pediatric Clinical Illness Score (PCIS), and mean GIF score for the first three days were combined. Results: The percent of patients with gastrointestinal dysfunction on the first day was 78.8%. Food intolerance (FI) and intra-abdominal hypertension (IAH) developed in 36.4% and 21.8% of the patients, respectively. The GIF score and mean GIF score for the first three days in children with different degrees of TBI were significantly different (P<0.05); these scores were also significantly different between patients who died and those who survived (P<0.05). The mean GIF score for the first three days was identified as an independent risk factor for mortality (odds ratio>1, 95% confidence interval=1.457 to 16.016, P<0.01), as was the PCIS. Receiver operating characteristic (ROC) curve analysis suggested that the mean GIF score for the first three days had the same calibrating power as the PCIS in discriminating the risk of death of children. Conclusion: The incidence of gastrointestinal dysfunction in children with TBI is high. The GIF score has the ability to reflect the status of the gastrointestinal system. The mean GIF score for the first three days has high prognostic value for ICU mortality in the SICU.

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Section: Discussioncontrasting

confidence: 82%

Gastrointestinal Failure Score in Children with Traumatic Brain Injury

Zhou

Lü

Tang³

2021

Preprint

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“…However, few studies on gastrointestinal injury have been reported in patients with COVID-19. Gastrointestinal dysfunction is common and closely related to adverse outcomes in critically ill patients[ 10 , 15 - 17 ]. In 2012, the Working Group on Abdominal Problems of the European Society of Intensive Care Medicine developed the definitions and a grading system for AGI in intensive care patients[ 10 ].…”

Section: Discussionmentioning

confidence: 99%

“…AGI was also correlated with clinical severity and outcomes of this novel disease. A recent meta-analysis showed that the incidence of AGI was about 40% and mortality was 33% in critically ill patients[ 15 ]. The corresponding data in this study were higher than those in previous reports.…”

Section: Discussionmentioning

confidence: 99%

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Acute gastrointestinal injury in critically ill patients with COVID-19 in Wuhan, China

Sun

Liu

Zou

et al. 2020

WJG

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BACKGROUND The coronavirus disease 2019 (COVID-19) is spreading rapidly around the world. Most critically ill patients have organ injury, including acute respiratory distress syndrome, acute kidney injury, cardiac injury, or liver dysfunction. However, few studies on acute gastrointestinal injury (AGI) have been reported in critically ill patients with COVID-19. AIM To investigate the prevalence and outcomes of AGI in critically ill patients with COVID-19. METHODS In this retrospective study, demographic data, laboratory parameters, AGI grades, clinical severity and outcomes were collected. The primary endpoints were AGI incidence and 28-d mortality. RESULTS From February 10 to March 10 2020, 83 critically ill patients out of 1314 patients with COVID-19 were enrolled. Seventy-two (86.7%) patients had AGI during hospital stay, of these patients, 30 had AGI grade I, 35 had AGI grade II, 5 had AGI grade III, and 2 had AGI grade IV. The incidence of AGI grade II and above was 50.6%. Forty (48.2%) patients died within 28 days of admission. Multiple organ dysfunction syndrome developed in 58 (69.9%) patients, and septic shock in 16 (19.3%) patients. Patients with worse AGI grades had worse clinical variables, a higher incidence of septic shock and 28-d mortality. Sequential organ failure assessment (SOFA) scores (95%CI: 1.374-2.860; P < 0.001), white blood cell (WBC) counts (95%CI: 1.037-1.379; P = 0.014), and duration of mechanical ventilation (MV) (95%CI: 1.020-1.340; P = 0.025) were risk factors for the development of AGI grade II and above. CONCLUSION The incidence of AGI was 86.7%, and hospital mortality was 48.2% in critically ill patients with COVID-19. SOFA scores, WBC counts, and duration of MV were risk factors for the development of AGI grade II and above. Patients with worse AGI grades had a higher incidence of septic shock and 28-d mortality.

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“…Відомо, що наявність порушення функції ШКТ в структурі коморбідних станів погіршує клінічний перебіг захворювання і прогноз пацієнта [25,26]. Зважаючи на це, вищенаведені зміни є обґрунтованою підставою для покращення клінічного перебігу захворювання, що проявляється в зменшенні тяжкості стану новонароджених за шкалою NTISS і підвищенні їх виживаності.…”

Section: рисунок 1 частота позитивної клінічної динаміки сгін в групunclassified

Цитоэнергетическая И Пробиотическая Оптимизация Интенсивной Терапии Синдрома Гастроинтестинальной Недостаточности У Новорожденных: Оценка Клинической Эффективности

Kholod¹,

Шкурупій²

2021

ЕМ

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гастроінтестинальної недостатності у новонароджених у критичних станах на тлі анатомо-функціональних особливостей обґрунтовує включення в терапію ергодинамічних сполук і пробіотиків. Мета дослідження: оцінка клінічної ефективності цитоенергетичної і пробіотичної оптимізації інтенсивної терапії синдрому гастроінтестинальної недостатності у новонароджених. Матеріали та методи. До групи дослідження ввійшли 146 новонароджених із гастроінтестинальною недостатністю в умовах інтенсивної терапії. До основної групи (n = 82) увійшли пацієнти, яким додатково призначали препарат меглюміну натрію сукцинату і пробіотик, що містить Lactobacillus acidophilus (spр. L.gasseri),

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Prevalence and outcome of acute gastrointestinal injury in critically ill patients

Abstract: Supplemental Digital Content is available in the text

Cited by 45 publications

References 22 publications

Gastrointestinal Failure Score in Children with Traumatic Brain Injury

Gastrointestinal Failure Score in Children with Traumatic Brain Injury

Acute gastrointestinal injury in critically ill patients with COVID-19 in Wuhan, China

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