Prevalence and neuro-psychiatric comorbidities of pediatric epilepsy in Taiwan: A national population-based study

Chiang, Kuo-Liang; Cheng, Chen-Yang

doi:10.1016/j.eplepsyres.2014.07.004

Cited by 33 publications

(24 citation statements)

References 42 publications

(75 reference statements)

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“…There are few studies investigating physical health issues in children with LD or to what extent LD may exist in children with physical diseases (Schieve et al 2012 ). One population-based study in Taiwan showed that the most common comorbid NDD among children with epilepsy was LD with a prevalence of 13% (Chiang and Cheng 2014 ). A Swedish study failed to show that children with T1DM had impaired academic ability (McCarthy et al 2002 ).…”

Section: Introductionmentioning

confidence: 99%

Physical health in children with neurodevelopmental disorders

Alabaf

Gillberg

Lundström

et al. 2018

J Autism Dev Disord

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With increasing numbers of children being diagnosed with neurodevelopmental disorders (NDDs) attention has been drawn to these children's physical health. We aimed to identify the prevalence of defined physical problems (epilepsy, migraine, asthma, cancer, diabetes, psoriasis, lactose intolerance, celiac disease, diarrhea, constipation, daytime enuresis, encopresis) in a nationwide population of 9-and 12-year-old twins subdivided into those with and without indications of NDDs. Parents of 28,058 twins participated in a well-validated telephone interview regarding their children's mental health and answered questions about their physical problems. The results indicate a high rate of physical problems in children with NDDs, particularly in those with indications of the presence of combinations of several NDDs.

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Section: Introductionmentioning

confidence: 99%

Physical health in children with neurodevelopmental disorders

Alabaf

Gillberg

Lundström

et al. 2018

J Autism Dev Disord

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“…The increase in the scores of the acceptability subscale implies that parents did not expect or cannot accept the comorbidities of epilepsy. 32 The subscale of demandingness represents the child demanding the parent's attention in various ways, including crying, misbehaving, and asking for help. However, their learning and behavioral problems make it difficult for their parents to understand what they want.…”

Section: Use All Patients As One Groupmentioning

confidence: 99%

Parenting stress in parents of children with refractory epilepsy before and after vagus nerve stimulation implantation

Chiu

Kuo

et al. 2017

Pediatrics & Neonatology

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“…The prevalence of epilepsy is approximately 6.8 per 1000 in the US [1], 5.5 per 1000 in Europe, 1.5 to 14 per 1000 in Asia [2], and 3.3 per 1000 in Taiwan [3]. Although there are many alternative treatment choices for epilepsy, including vagus nerve stimulation (VNS), surgery, and a ketogenic diet, anti-epileptic drugs (AEDs) are always the first choice because numerous patients with epilepsy were seizure-free while taking an AED [4].…”

Section: Introductionmentioning

confidence: 99%

The Impact of Anti-Epileptic Drugs on Growth and Bone Metabolism

Fan

Lee

Chang

et al. 2016

IJMS

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Epilepsy is a common neurological disorder worldwide and anti-epileptic drugs (AEDs) are always the first choice for treatment. However, more than 50% of patients with epilepsy who take AEDs have reported bone abnormalities. Cytochrome P450 (CYP450) isoenzymes are induced by AEDs, especially the classical AEDs, such as benzodiazepines (BZDs), carbamazepine (CBZ), phenytoin (PT), phenobarbital (PB), and valproic acid (VPA). The induction of CYP450 isoenzymes may cause vitamin D deficiency, hypocalcemia, increased fracture risks, and altered bone turnover, leading to impaired bone mineral density (BMD). Newer AEDs, such as levetiracetam (LEV), oxcarbazepine (OXC), lamotrigine (LTG), topiramate (TPM), gabapentin (GP), and vigabatrin (VB) have broader spectra, and are safer and better tolerated than the classical AEDs. The effects of AEDs on bone health are controversial. This review focuses on the impact of AEDs on growth and bone metabolism and emphasizes the need for caution and timely withdrawal of these medications to avoid serious disabilities.

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Prevalence and neuro-psychiatric comorbidities of pediatric epilepsy in Taiwan: A national population-based study

Cited by 33 publications

References 42 publications

Physical health in children with neurodevelopmental disorders

Physical health in children with neurodevelopmental disorders

Parenting stress in parents of children with refractory epilepsy before and after vagus nerve stimulation implantation

The Impact of Anti-Epileptic Drugs on Growth and Bone Metabolism

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