Abstract:Background:
Sickle cell disease (SCD) is the most common hereditary red blood cell disorder in the United States (USA) and primarily affects African-Americans. Of the four most common sickle cell genotypes, SS and Sβ0 are associated with greater severity, including more ischemia due to sickling and more profound microvascular changes from chronic sickling, as compared to those with the Sβ+ and SC genotypes. African-Americans suffer from high rates of Type 2 Diabetes mellitus (T2DM), a disease as… Show more
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.