2021
DOI: 10.1016/j.jgar.2020.11.006
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Prevalence and molecular characterisation of carbapenemase-producing Enterobacterales in an outbreak-free setting in a single hospital in Uruguay

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Cited by 11 publications
(8 citation statements)
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“…The presence of the MDR phenotype was associated with the main ESBL gene characterized, bla CTX-M-15 . CTX-M-15 is an enzyme frequently reported in K. pneumoniae worldwide [30] and in our region in particular [11,12,31,32]. MIC 50 , MIC 90, and resistance values were high for all antibiotics (except for amikacin) when EUCAST-2012 breakpoints were used.…”
Section: Discussionmentioning
confidence: 79%
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“…The presence of the MDR phenotype was associated with the main ESBL gene characterized, bla CTX-M-15 . CTX-M-15 is an enzyme frequently reported in K. pneumoniae worldwide [30] and in our region in particular [11,12,31,32]. MIC 50 , MIC 90, and resistance values were high for all antibiotics (except for amikacin) when EUCAST-2012 breakpoints were used.…”
Section: Discussionmentioning
confidence: 79%
“…The high resistance values for the analyzed antibiotics are related to the co-existence of different antibiotic resistance mechanisms within the same K. pneumoniae isolate. We characterized different combinations of genes arrays in the same isolate: bla CTX-M-15 ; aac(6 ′ )Ib, aadA, and B alleles; aac(6 ′ )Ib-cr, qnrA, and B variants; and dfr types and class 1 integrons, conferring resistance to third-generation cephalosporins, aminoglycosides, fluoroquinolones, and trimethoprim-sulfamethoxazole, respectively [9,12]. It is important to remark that trimethoprim-sulfamethoxazole could be an appropriate treatment option in the cases of urine isolates with MIC values of 40 mg/L.…”
Section: Discussionmentioning
confidence: 99%
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