Prevalence and molecular characterisation of the sessile serrated adenoma in a subset of the Chinese population

Qiu, Ye; Fu, Xiangsheng; Zhang, Wei; Xu, Yong; Xiao, Lanyue; Chen, Xia; Shi, Lei; Zhou, Xian; Xia, Guodong; Yan, Peng; Ming-ming, Deng

doi:10.1136/jclinpath-2013-202092

Cited by 11 publications

(8 citation statements)

References 38 publications

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“…The prevalence of SSA/P in our population was 1.4%, and this result was consistent with previous studies. 26,27 The present study included asymptomatic subjects who received screening colonoscopy as part of a general health checkup not specific for CRC screening, therefore minimizing the possibility of bias. Moreover, positivity rates of 10.4%, 6.2%, and 5.0% at cutoffs of 10, 15, and 20 mg/g, respectively, are within the range of FIT positivity reported by several FIT-based screening programs or trials in the general population, 3,18,28 which again supports our cohort as representative of the general population.…”

Section: Discussionmentioning

confidence: 99%

Fecal Immunochemical Test Detects Sessile Serrated Adenomas and Polyps With a Low Level of Sensitivity

Chang

Shun

Hsu

et al. 2017

Clinical Gastroenterology and Hepatology

112

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Section: Discussionmentioning

confidence: 99%

Fecal Immunochemical Test Detects Sessile Serrated Adenomas and Polyps With a Low Level of Sensitivity

Chang

Shun

Hsu

et al. 2017

Clinical Gastroenterology and Hepatology

112

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“…[ 40 41 ] Some studies in Chinese population also suggested the similar low prevalence of SSA/Ps. [ 42 43 ] Various factors including the patients’ population, colonoscopy quality, pathologic validation, variation between centers, and ethnicity might cause these differences. [ 10 21 ] In addition, inadequate communication between pathologists and endoscopists, ignorance of inconspicuous rectal polyps, and lack of validated classification criterion may also contribute to the missing rate in Chinese patients.…”

Section: Discussionmentioning

confidence: 99%

Detection Rate, Distribution, Clinical and Pathological Features of Colorectal Serrated Polyps

Cao

Chen

et al. 2016

Chinese Medical Journal

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Background:Colorectal serrated polyp is considered as histologically heterogeneous lesions with malignant potential in western countries. However, few Asian studies have investigated the comprehensive clinical features of serrated polyps in symptomatic populations. The aim of the study was to evaluate the features of colorectal serrated polyps in a Chinese symptomatic population.Methods:Data from all consecutive symptomatic patients were documented from a large colonoscopy database and were analyzed. Chi-square test or Fisher's exact test and logistic regression analysis were used for the data processing.Results:A total of 9191 (31.7%) patients were detected with at least one colorectal polyp. The prevalence of serrated polyps was 0.53% (153/28,981). The proportions of hyperplastic polyp (HP), sessile serrated adenoma/polyp (SSA/P), and traditional serrated adenoma (TSA) of all serrated polyps were 41.2%, 7.2%, and 51.6%, respectively, which showed a lower proportion of HP and SSA/P and a higher proportion of TSA. Serrated polyps appeared more in males and elder patients while there was no significant difference in the subtype distribution in gender and age. The proportions of large and proximal serrated polyps were 13.7% (21/153) and 46.4% (71/153), respectively. In total, 98.9% (89/90) serrated adenomas were found with dysplasia. Moreover, 14 patients with serrated polyps were found with synchronous advanced colorectal neoplasia, and large serrated polyps (LSPs) (odds ratio: 3.446, 95% confidence interval: 1.010–11.750, P < 0.05), especially large HPs, might have an association with synchronous advanced neoplasia (AN).Conclusions:The overall detection rate of colorectal serrated polyps in Chinese symptomatic patient population was low, and distribution pattern of three subtypes is different from previous reports. Moreover, LSPs, especially large HPs, might be associated with an increased risk of synchronous AN.

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“…[22–25] One Chinese study reported a 14.3% BRAF V600E mutation rate in SSA, which is a lower rate than in the Western population. [26] One Korean study reported that BRAF V600E mutations are found in 43.5% to 58.3% of TSAs. [27] In our study, the rates of BRAF V600E mutation were 47.2% in TSA and 41.2% in SSA, consistent with other studies.…”

Section: Discussionmentioning

confidence: 99%

Molecular characteristics of colorectal serrated polyps and hyperplastic polyps

Sambuudash

Kim²,

et al. 2016

Medicine

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The serrated neoplasia pathway of colorectal carcinogenesis is characterized by BRAF mutation and aberrant DNA methylation, which have not been reported on Korean patients. The aim of this study was to investigate BRAF mutation and DNA methylation in colorectal serrated polyps and the right colon.Between 2005 and 2013, 146 colon polyps (47 tubular adenomas [TAs], 53 traditional serrated adenomas [TSAs], 17 sessile serrated adenomas/polyps [SSAs], and 29 hyperplastic polyps in the proximal colon [PHPs]) were collected from patients. Paraffin-embedded colon polyp tissue was used for DNA extraction. BRAF V600E mutation was identified through polymerase chain reaction (PCR) and pyrosequencing assay. The methylation status of the long interspersed nucleotide element-1, insulin-like growth factor binding protein 7 (IGFBP7), mutL homolog 1 (hMLH1), and CD133 genes were evaluated through disulfite conversion, PCR, and pyrosequencing assay.BRAF V600E mutation was found in 2.1% of TAs, 47.2% of TSAs, 41.2% of SSAs, and 20.7% of PHPs. TSA and SSA had higher BRAF mutation rates than did TA (P < 0.0001). TSA had higher BRAF mutation rates than did PHP (P = 0.018). IGFBP7 hypermethylation was found in 17% of TAs, 37.7% of TSAs, 88.2% of SSAs, and 37.5% of PHPs. TSA and SSA had higher hypermethylation of IGFBP7 than did TA (P = 0.021 and P < 0.0001, respectively). SSA had higher hypermethylation of IGFBP7 than did PHP (P = 0.002). hMLH1 hypermethylation was found in 2.1% of TAs, 5.7% of TSAs, 0% of SSAs, and 0% of PHPs. CD133 hypermethylation was found in 21.3% of TAs, 9.4% of TSAs, 35.3% of SSAs, and 17.4% of PHPs.BRAF mutation and methylation in TSA and SSA are different from those in PHP in Koreans. These findings suggested that PHP may have different molecular characteristics compared with other serrated polyps.

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Prevalence and molecular characterisation of the sessile serrated adenoma in a subset of the Chinese population

Cited by 11 publications

References 38 publications

Fecal Immunochemical Test Detects Sessile Serrated Adenomas and Polyps With a Low Level of Sensitivity

Fecal Immunochemical Test Detects Sessile Serrated Adenomas and Polyps With a Low Level of Sensitivity

Detection Rate, Distribution, Clinical and Pathological Features of Colorectal Serrated Polyps

Molecular characteristics of colorectal serrated polyps and hyperplastic polyps

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