Prevalence and Location of Mast Cell Tumors in Slaughter Cattle

Hill, John E.; Langheinrich, K. A.; Kelley, Lynda C.

doi:10.1177/030098589102800514

Cited by 18 publications

(30 citation statements)

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“…The current case is one of mast cell tumors but also is cytologically associated with myeloid leukemia cells [10]. This type of neoplasm may occur preferentially in calves, because both mastocytoma and myeloid leukemia are not infrequent in calves [8,10].…”

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confidence: 85%

“…In contrast, cases without skin lesions have a worse prognosis and may progress to transformation into mast cell leukemia or, more commonly, acute myeloblastic leukemia [9]. Highly malignant mast cell disorders such as mast cell leukemia and mast cell sarcoma are cytologically distinct from indolent systemic mastocytosis [2], and are not always associated with the mastocytosis [3].In cattle, mastocytoma is a benign or low malignancy neoplasm of mast cell origin, occurring chiefly in the skin [8]. Although multiple skin lesions or metastases in visceral organs are not infrequent, cutaneous mastocytomas are characterized by rare or absent mitotic figures [8].…”

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confidence: 99%

“…Although multiple skin lesions or metastases in visceral organs are not infrequent, cutaneous mastocytomas are characterized by rare or absent mitotic figures [8]. Leukemias of the mast cell lineage [19] or with both mastocytic and megakaryocytic differentiation [10] have been observed in cattle.…”

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confidence: 99%

“…In cattle, mastocytoma is a benign or low malignancy neoplasm of mast cell origin, occurring chiefly in the skin [8]. Although multiple skin lesions or metastases in visceral organs are not infrequent, cutaneous mastocytomas are characterized by rare or absent mitotic figures [8].…”

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confidence: 99%

“…Bovine cutaneous mastocytoma, which is composed of a monotonous population of neoplastic mast cells with oval nuclei, may show visceral metastasis, but mitotic figures are few or absent [8]. It is considered to be a benign or low malignancy neoplasm.…”

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Mast Cell Sarcoma with Megakaryocytic Differentiation in a Calf

Fujimoto

Wada

Kanada³

et al. 2012

The Journal of Veterinary Medical Science

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ABSTRACT. A case of mast cell sarcoma in a 5-month-old Holstein female calf is described. Macroscopically, enlargement of the spleen, lymph nodes, tonsils and kidneys was noted, and there were tumor masses in the neck region and on the pleura and peritoneum. The pericardium and uterine and ureter walls were also involved by tumor. Most neoplastic cells had eosinophilic granules, which were metachromatic and positive for naphthol AS-D chloroacetate esterase and tryptase, whereas smaller numbers of cells were positive for factor VIII-related antigen, a marker of megakaryocytes. Some of the predominant type of these tumor cells were found within the epithelia of the lungs, tonsils, gastrointestinal tract, liver, ureters, urinary bladder and uterus. Their normal counterparts were considered to be globule leukocytes. KEY WORDS: cattle, epitheliotropism, globule leukocyte, mast cell sarcoma.doi: 10.1292/jvms.12-0236; J. Vet. Med. Sci. 74(12): 1643-1646, 2012 Mast cell tumors in dogs are the most frequent malignant or potentially malignant tumor of the skin [7]. In humans, systemic mastocytosis is a disease caused by a neoplastic proliferation of mast cells. Most cases have the skin lesions of urticaria pigmentosa, and the majority of these have a relatively benign course [2]. In contrast, cases without skin lesions have a worse prognosis and may progress to transformation into mast cell leukemia or, more commonly, acute myeloblastic leukemia [9]. Highly malignant mast cell disorders such as mast cell leukemia and mast cell sarcoma are cytologically distinct from indolent systemic mastocytosis [2], and are not always associated with the mastocytosis [3].In cattle, mastocytoma is a benign or low malignancy neoplasm of mast cell origin, occurring chiefly in the skin [8]. Although multiple skin lesions or metastases in visceral organs are not infrequent, cutaneous mastocytomas are characterized by rare or absent mitotic figures [8]. Leukemias of the mast cell lineage [19] or with both mastocytic and megakaryocytic differentiation [10] have been observed in cattle. Here, we report, in a calf, a mast cell sarcoma that possessed mast cell features such as metachromasia and tryptase positivity, but also factor VIII-related antigen expression in a minority of cells.A 5-month-old Holstein female calf exhibited enlargement of the superficial lymph nodes, emaciation, growth retardation, rough hair coat and a rectal temperature of 40.5°C. The next day, hematological values were as follows: hematocrit, 17%; white blood cell count, 8,560 cells/ µl with 2% neutrophils, 43% lymphocytes, 1% monocytes and 54% atypical cells with nuclear irregularity and/or coarse azurophilic granules in the cytoplasm. Antibodies to bovine leukosis virus (BLV) were not detected by the agar gel immunodiffusion test. A clinical diagnosis of calf-form leukosis was made, and euthanasia was performed seven days after the initial examination.At necropsy, the superficial lymph nodes were highly to moderately enlarged, and were grayish white and homogeneous on c...

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confidence: 85%

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confidence: 99%

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confidence: 99%

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confidence: 99%

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