Prevalence and incidence of systemic lupus erythematosus in South Korea

Shim, Jina; Sung, Yoon‐Kyoung; Joo, Young Bin; Lee, Hye‐Soon; Bae, Sang Cheol

doi:10.1007/s00296-013-2915-9

Cited by 41 publications

(31 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although there was a slight bimodal pattern in incidence by age, the peak age of incidence in this study was between 25-39 years, with a lower incidence rate in the early (20-24 years) and late (40-44 years) childbearing age periods, suggesting that women are at risk of developing SLE during the period of time when they are most likely to have children (25-39 years). These results are consistent with previous Koreans studies that have reported a peak age of incidence in the 30-39 year age ranges [7,21]. The peak age of incidence for SLE in other countries varies: Taiwan and Spain have peak incidence at the age of 20-29, and in Norway, the peak incidence age is 16-29 [11,31,32].…”

Section: Discussionsupporting

confidence: 91%

Incidence and prevalence of systemic lupus erythematosus among Korean women in childbearing years: a nationwide population-based study

Chung¹,

Park²,

Lim³

et al. 2020

Preprint

View full text Add to dashboard Cite

Background Most women with systemic lupus erythematosus (SLE) are diagnosed with the disease in their reproductive years, but the incidence and prevalence of SLE among women of childbearing age have not been studied. The objective of this study was to estimate the incidence and prevalence of SLE among the Korean women of childbearing age. Methods Women aged 20 to 44 years with SLE were identified from National Health Insurance Service – National Health Information Database (2009–2016), which contain health information of approximately 97% of the Korean population. SLE was defined by International Classification of Diseases, 10th revision code, M32. Incidence and prevalence were calculated per 100,000 person-years and stratified by year and age. Results A total of 12,756 women with SLE were identified. The incidence of SLE from 2011 to 2016 among women in childbearing years was 8.18/100,000 person-years (95% CI 7.94–8.43), with the highest incidence in 2016 (8.56/100,000 person-years, 95% CI 7.95–9.17) and the lowest incidence in 2012 (7.85/100,000 person-years, 95% CI 7.28–8.42). The prevalence of SLE from 2009 to 2016 among women in childbearing years was 77.07/100,000 person-years (95% CI 75.76–78.39), with the highest prevalence in 2014 (79.47/100,000 person-years, 95% CI 77.64–81.30) and the lowest in 2010 (74.19/100,000 person-years, 95% CI 72.45–75.93). The peak age for SLE incidence was between 25–39 years, and lower incidence was seen in the early (20–24 years) and late (40–44 years) childbearing age periods. There was an increasing trend in prevalence according to age in women of childbearing age, with the highest prevalence occurring in the 40–44 age group. Conclusions The risk and burden of SLE are high among women during their childbearing years. This calls for special attention to this particular population group when allocating health resources.

show abstract

Section: Discussionsupporting

confidence: 91%

Incidence and prevalence of systemic lupus erythematosus among Korean women in childbearing years: a nationwide population-based study

Chung¹,

Park²,

Lim³

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…According to grades of renal biopsy ,in our study ,the distribution of anaemia increase by increasing the grades of renal biopsy but thrombocytopenia was 75% in class (5), 35% in class (4), 50% in class (3) and about 13% in class (2). These results near to the results of (5) which revealed that thrombocytopenia was 80 % in class (5), 32% in class (4), 47 % in class (3) and 12 % in class (2). The study revealed that there was high serum creatinine > 1.3 mg in more than 50% of class (4) and class (5) patients , Although the study of (11) revealed that low percentage of the patients of these classes were affected by high serum creatinine as 34% of class (4) and 41% of class (5) were affected , this may be explained by non compliance of our patients for treatment and by different locality.24 h urinary protein > .5 g affect most of the patients of the studied group , our study as the study (7) as 24 h urinary protein > .5 g affected about 90 % of the patients.…”

Section: Discussionsupporting

confidence: 87%

Pattern of Renal involvement in Systemic Lupus Erythematosus patients in Sohag University Hospitals

Hassanin

Zaki

Elsamman

et al. 2018

Sohag Medical Journal

View full text Add to dashboard Cite

Background: Systemic Lupus Erythematosus is asystemic disease characterized by multiple system affection,each system affected has apathognomonic features for lupus affection,renal involvement have variable patterns in SLE and tretment vary accordingly. Objective: The objective of this study is to study pattern of renal involvement in Systemic Lupus Erythematosus patients in Sohag University Hospitals. Materials &Methods:This study was performed on 100 patients with SLE who fulfiled the clinical and laboratory criteria of (Modified american colleague of rheumatology for SLE diagnosis-1997) admitted to Sohag University Hospital and those of outpatients clinic were studied by means of a retrospective review of their records, Patients were analyzed according to their clinical symptoms and laboratory profile which included complete blood counts, serum creatinine and electrolytes, ESR, total proteins, 24 hour urinary proteins, creatinine clearance, anti nuclear factor and anti-DNA. Results of renal biopsy which were performed by light microscopy study were revised. Results: The study revealed that class(2) were 46 patients (46%) all of them were females.Class (3) were 36 patients (36%), 33 of them were females, 3 patients were males.Class (4) were 14 patients (14%) all of them were females .Class (5) were 4 patients (4%) all of them were females. According to proteinuria between classes of renal biopsy , 24 h urinary protein was > .5 g in all patients of class 5 (100%) .Class (3) and class (4) the same range (about 92%), class 2 about (84%). Conclusion: Our study in Sohag University Hospitals was in 100 patients revealed that roughly number of rural patients equal to urban patients , also revealed that the most common renal biopsy class is the class (2) in our locality and that the most common symptoms associated with renal involvement is arthritis followed by oral ulceration. Anaemia affect most of our patients in Sohag and thrombocytopenia very common between them , our study show that proteinuria increased markedly by increasing grades of renal biopsy with low response to treatment, this may explained by non compliance of our patients to treatment .

show abstract

“…[Epub ahead of print] ics, and Asians, and both the prevalence and incidence of SLE are increasing in the Korean population [3]. In Korea, the prevalence and incidence of SLE between 2006 and 2010 was 20.6 to 26.5 (per 100,000 person) and over 2.5 (per 100,000 person), respectively [4]. SLE is a chronic systemic autoimmune disorder that commonly affects bone homeostasis, which is associated with increased serum levels of various inflammatory cytokines, premature menopause, and maintaining glucocorticoids therapy [5][6][7][8][9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Incidence and risk factors for osteoporotic fractures in patients with systemic lupus erythematosus versus matched controls

Kim

Han

Jung

et al. 2021

Korean J Intern Med

View full text Add to dashboard Cite

Background/Aims: Despite recent improvements in the quality of life of patients with systemic lupus erythematosus (SLE), osteoporosis, and osteoporotic fractures are one of the major complications of SLE. Furthermore, limited data are available on the incidence and predictor of osteoporotic fractures in Korean patients with SLE. Herein, we aimed to assess the incidence and risk factors for osteoporotic fractures in Korean SLE patients compared to those without SLE. Methods: SLE patients aged ≥ 40 years (n = 10,434; mean age, 51.3 ± 9.1 years; women, 89.7%) were selected from the Korean National Health Insurance Service database, spanning a period from 2008 to 2014. Age-and sex-matched controls (n = 52,170) were randomly sampled in a 5:1 ratio from non-SLE individuals. The primary outcome was the first occurrence of osteoporotic fracture. Results: The incidence of osteoporotic fractures was significantly higher in the SLE patients (19.085 per 1,000 person-years) than in matched controls (6.530 per 1,000 person-years). According to the multivariable Cox proportional analysis, patients with SLE exhibited a higher osteoporotic fracture rate than the control group (hazards ratio, 2.964; 95% confidence interval, 2.754 to 3.188), even after adjustment for confounding variables. In the subgroup analysis, male SLE patients or SLE patients aged 40 to 65 years were associated with a higher osteoporotic fracture rate than women SLE patients or SLE patients aged ≥ 65 years, respectively. Conclusions: We found a 2.964-fold increased risk of osteoporotic fracture in SLE patients compared to age-and sex-matched non-SLE controls. Male or middle-aged SLE patients had a relatively higher fracture risk among patients with SLE.

show abstract

Prevalence and incidence of systemic lupus erythematosus in South Korea

Cited by 41 publications

References 37 publications

Incidence and prevalence of systemic lupus erythematosus among Korean women in childbearing years: a nationwide population-based study

Incidence and prevalence of systemic lupus erythematosus among Korean women in childbearing years: a nationwide population-based study

Pattern of Renal involvement in Systemic Lupus Erythematosus patients in Sohag University Hospitals

Incidence and risk factors for osteoporotic fractures in patients with systemic lupus erythematosus versus matched controls

Contact Info

Product

Resources

About