Prevalence and Incidence of Helicobacter pylori Infection in a Healthy Pediatric Population in the Lisbon Area

Oleastro, Mónica; Pelerito, Ana; Nogueira, Paulo; Benoliel, João; Santos, Andrea; Cabral, José; Lopes, Ana Isabel; Ramalho, Paulo; Monteiro, Lurdes

doi:10.1111/j.1523-5378.2011.00858.x

Cited by 53 publications

(60 citation statements)

References 57 publications

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“…In Portugal, the first national study addressing H. pylori prevalence (assessed by serology), published in 1994, showed that the prevalence of infection among children aged between 3 and 14 years was 46.2% [26]. In a recent study conducted in the south of Portugal, the prevalence of H. pylori infection (assessed by stool antigen test) in children aged between 3 and 14 years of age was 39.3%, and 51.5% in children aged between 11 and 15 years [27]. The prevalence found in our study is higher, which explains the higher gastric cancer incidence found in the North of Portugal [13,28].…”

Section: Discussionmentioning

confidence: 99%

“…In more recent studies, the annual rates were 1.5% in Japan [29], 1.4% in the USA [30], 2.5% in Turkey [31] and 7.0% in Turkish children living in Germany [31,32]. In a study from the South of Portugal, conducted between 2003 and 2006 it was 10.5/100 child-years in the age group 11-15 years [27], though only 52% participated in the follow-up study and from these 60% were lost during the 3-year follow-up.…”

Section: Discussionmentioning

confidence: 99%

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Prevalence, incidence and risk factors for Helicobacter pylori infection in a cohort of Portuguese adolescents (EpiTeen)

Bastos

Peleteiro

Pinto

et al. 2013

Digestive and Liver Disease

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a b s t r a c tBackground: Helicobacter pylori infection is acquired mainly during childhood, but it may occur throughout life. Understanding the determinants of infection at different ages is essential to clarify dynamics of H. pylori related diseases and to design preventive strategies. Aim: To estimate the prevalence of H. pylori infection at the age of 13 and the incidence after a 3-year follow-up and to identify risk factors for infection. Subjects and methods: Adolescents born in 1990 were recruited in schools from Porto. Whole-cell anti-H. pylori IgG antibodies were quantified by ELISA. Prevalence ratios (PR) and incidence rate ratios (RR) adjusted for parental education were computed at baseline (n = 1312) and at follow-up (n = 280). Results: The prevalence was 66.2%, lower in subjects with more educated parents (PR = 0.72, 95%CI: 0.63-0.82), and higher for those having more than one sibling (PR = 1.10, 95%CI: 1.02-1.19) and for smokers (PR = 1.11, 95%CI: 1.02-1.20). The incidence was 4.1/100 person-years. Smoking (RR = 2.35, 95%CI: 1.16-4.75) and type of school (RR = 0.38, 95%CI: 0.16-0.95) were associated with the incidence of infection. Conclusions: Prevalence and incidence of H. pylori infection were high, suggesting that gastric cancer will remain an important public health problem in this generation of Portuguese. We identified smoking as a modifiable risk factor for infection.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Prevalence, incidence and risk factors for Helicobacter pylori infection in a cohort of Portuguese adolescents (EpiTeen)

Bastos

Peleteiro

Pinto

et al. 2013

Digestive and Liver Disease

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“…On the other hand, children living in houses with their own drainage system were more protected from this infection ( p = 0.038; OR = 0.10; 95%CI: 0.02-0.64). Children were also tested for H. pylori infection by antigen stool detection [17], and co-infection was detected in 25 children (p < 0.037; OR = 1.82; 95%CI: 1.05-3.15). A sub-set of children negative for H. pylori infection were monitored every 6 months, during 36 months, in order to evaluate the incidence of H. pylori infection [16].…”

Section: Resultsmentioning

confidence: 99%

Prevalence and risk factors for Giardia duodenalis infection among children: A case study in Portugal

et al. 2012

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BackgroundGiardia duodenalis is a widespread parasite of mammalian species, including humans. The prevalence of this parasite in children residing in Portugal is currently unknown. This study intended to estimate G. duodenalis infection prevalence and identify possible associated risk factors in a healthy paediatric population living in the District of the Portuguese capital, Lisbon.MethodsBetween February 2002 and October 2008, 844 children were randomly selected at healthcare centres while attending the national vaccination program. A stool sample and a questionnaire with socio-demographic data were collected from each child. Giardia infection was diagnosed by direct examination of stools and antigen detection by ELISA.ResultsThe population studied revealed a gender distribution of 52.8% male and 47.2% female. Age distribution was 47.4% between 0-5 years and 52.6% between 6-15 years.The prevalence of Giardia infection was 1.9% (16/844) when estimated by direct examination and increased to 6.8% (57/844) when ELISA results were added. The prevalence was higher among children aged 0-5 years (7.8%), than among older children (5.8%), and was similar among genders (6.9% in boys and 6.5% in girls). The following population-variables were shown to be associated risk factors for G. duodenalis infection: mother's educational level (odds ratio (OR)= 4.49; confidence interval (CI): 1.20-16.84), father's educational level (OR = 12.26; CI: 4.08-36.82), presence of Helicobacter pylori infection (OR = 1.82; CI: 1.05-3.15), living in houses with own drainage system (OR = 0.10; CI: 0.02-0.64) and reported household pet contact, especially with dogs (OR = 0.53; CI: 0.31-0.93).ConclusionThe prevalence of giardiasis in asymptomatic children residing in the region of Lisbon is high. Several risk factors were associated with Giardia prevalence and highlight the importance of parents' education and sanitation conditions in the children's well being. The association between G. duodenalis and H. pylori seems an important issue deserving further investigation in order to promote prevention or treatment strategies.

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“…This study was conducted in the Pediatric clinics at the National Hepatology and Tropical Medicine Research Institute, Abou El-Rish Hospital at Cairo University as well as Benha University Hospital after Institutional Review Board (IRB) approval during the period from July, 2012 to October, 2013. In this cross-sectional study, 80 children was included and presenting with recurrent abdominal pain, which is defined as at least 3 discrete episodes of abdominal pain of sufficient severity to interrupt normal daily activities or performance over H. pylori infection was 31.6% and such rate can increase by age [22] . However, other studies have shown that the prevalence of H. pylori infection in children is independent of age [23,24] .…”

Section: Patientsmentioning

confidence: 99%

Correlation of Helicobacter Pylori Infection With IL-8 and Recurrence of Abdominal Pain: Our Experience from an Endemic Area

Mohamed¹,

Mina

Tosson

et al. 2016

Journal of Gastroenterology and Hepatology Research

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Prevalence and Incidence of Helicobacter pylori Infection in a Healthy Pediatric Population in the Lisbon Area

Cited by 53 publications

References 57 publications

Prevalence, incidence and risk factors for Helicobacter pylori infection in a cohort of Portuguese adolescents (EpiTeen)

Prevalence, incidence and risk factors for Helicobacter pylori infection in a cohort of Portuguese adolescents (EpiTeen)

Prevalence and risk factors for Giardia duodenalis infection among children: A case study in Portugal

Correlation of Helicobacter Pylori Infection With IL-8 and Recurrence of Abdominal Pain: Our Experience from an Endemic Area

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