Prevalence and impact of neuropsychiatric symptoms in normal aging and neurodegenerative syndromes: A population‐based study from Latin America

Rodriguez Salgado, Ana M.; Acosta, Isaac; Kim, Dani J.; Zitser, Jennifer; Sosa, Ana Luisa; Acosta, Daisy; Jimenez‐Velasquez, Ivonne Z.; Guerra, Mariella; Salas, Aquiles; Valvuerdi, Adolfo; Llibre‐Guerra, Juan C.; Jeyachandran, Christine; Contreras, Ricardo López; Hesse, Heike; Tanner, Caroline; Llibre Rodriguez, Juan J.; Prina, Matthew; Llibre‐Guerra, Jorge J.

doi:10.1002/alz.13384

Cited by 3 publications

(1 citation statement)

References 87 publications

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“…AD represents the most prevalent form of dementia, and nearly all patients experience neuropsychiatric symptoms, with depression being one of the most common psychiatric disorders, in conjunction with cognitive and memory deficits ( Lyketsos et al, 2011 ; Santos et al, 2016 ; Depp et al, 2023 ; Rodriguez Salgado et al, 2023 ; Tremblay et al, 2023 ). Importantly, depression not only manifests as an early symptom of AD dementia but also increases the risk of AD, and conversely, depressive disorders can also arise in response to cognitive decline due to AD ( Elser et al, 2023 ; Liao et al, 2023 ), suggesting a crucial and bidirectional association between AD and depression.…”

Section: Sex Differences In the Relationship Between Ad And Depressionmentioning

confidence: 99%

Sex differences in the relationship between depression and Alzheimer’s disease—mechanisms, genetics, and therapeutic opportunities

Chen,

Wang,

Liu

et al. 2024

Front. Aging Neurosci.

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Depression and Alzheimer’s disease (AD) are prevalent neuropsychiatric disorders with intriguing epidemiological overlaps. Their interrelation has recently garnered widespread attention. Empirical evidence indicates that depressive disorders significantly contribute to AD risk, and approximately a quarter of AD patients have comorbid major depressive disorder, which underscores the bidirectional link between AD and depression. A growing body of evidence substantiates pervasive sex differences in both AD and depression: both conditions exhibit a higher incidence among women than among men. However, the available literature on this topic is somewhat fragmented, with no comprehensive review that delineates sex disparities in the depression–AD correlation. In this review, we bridge these gaps by summarizing recent progress in understanding sex-based differences in mechanisms, genetics, and therapeutic prospects for depression and AD. Additionally, we outline key challenges in the field, holding potential for improving treatment precision and efficacy tailored to male and female patients’ distinct needs.

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Section: Sex Differences In the Relationship Between Ad And Depressionmentioning

confidence: 99%

Sex differences in the relationship between depression and Alzheimer’s disease—mechanisms, genetics, and therapeutic opportunities

Chen,

Wang,

Liu

et al. 2024

Front. Aging Neurosci.

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Racial/ethnic differences in neuropsychiatric disturbances associated with incident dementia

Wise,

Yan,

et al. 2024

Alz & Dem Diag Ass & Dis Mo

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INTRODUCTIONNeuropsychiatric symptoms (NPS) are nearly universal in dementia; some cross‐sectional studies of NPS in dementia have found racial/ethnic differences, though it is unknown if NPS prevalence differs among racial/ethnic groups before and after dementia diagnosis.METHODSParticipants were followed annually at Alzheimer's Disease Centers and were assessed on the Neuropsychiatric Inventory‐Questionnaire (NPI‐Q) with at least one follow‐up visit at which they were diagnosed with dementia. Descriptive statistics were generated by race/ethnicity. NPS were modeled over time as a function of race/ethnicity and with diagnosis date as the baseline.RESULTSNPS were present in 95% in at least one time point. After adjusting for covariates, there were no statistically significant differences in NPI‐Q total scores among racial/ethnic groups at the time of and after dementia diagnosis.DISCUSSIONFindings from our prospective cohort study suggest that when individuals are matched at the time of conversion to dementia, there are no racial/ethnic differences in NPS.Highlights Neuropsychiatric symptoms of dementia are frequent and increase caregiver burden. Prior studies reported more neuropsychiatric symptoms (NPS) in Black compared to White individuals with dementia. National Alzheimer's Coordinating Center Black, White, and Hispanic participants did not differ in NPS at the time of dementia diagnosis.

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Cross‐Sectional and Prospective Associations between Parkinsonism and Parkinson's Disease with Frailty in Latin America

Kim,

Khan,

Llibre‐Rodriguez

et al. 2024

Movement Disord Clin Pract

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BackgroundLittle is known about the relationship between parkinsonism or Parkinson's disease (PD) and frailty in Latin America.ObjectiveThe study aimed to determine the cross‐sectional and prospective associations between parkinsonism and PD with frailty in a large multi‐country cohort in Latin America. Frailty was assessed using three different models to explore which definitions are more appropriate to screen for frailty in a PD population.Methods12,865 older adults (aged ≥65 years) from the 10/66 population‐based cohort study in six Latin American countries were analyzed. Logistic regression models assessed the cross‐sectional association between parkinsonism/PD with baseline frailty. Individual country analyses were combined via fixed‐effect meta‐analysis. In non‐frail participants who were followed up for 4 years, Cox proportional hazards regression models assessed the prospective association between parkinsonism/PD with incident frailty accounting for competing risk of mortality.ResultsAt baseline, the prevalence of parkinsonism and PD was 7% and 2%, respectively, and the prevalence of frailty varied across the three models with rates of 18% for frailty phenotype, 20% for frailty index and 30% for multidimensional frailty model. PD was associated with baseline and incident frailty after accounting for age, sex, and education: odds ratios and 95% confidence intervals (95% CI) for frailty were 2.49 (95% CIs 1.87–3.31), 2.42 (95% CIs 1.80–3.25), and 1.57 (95% CIs 1.16–2.21), and cause‐specific hazard ratios were 1.66 (95% CIs 1.07–2.56), 1.78 (95% CIs 1.05–3.03), and 1.58 (95% CIs 0.91–2.74). Similar results were found for parkinsonism.ConclusionParkinsonism and PD were cross‐sectionally and prospectively associated with frailty in Latin America. Routine screening for frailty in PD patients may aid earlier detection of those at greater risk of adverse outcomes.

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Prevalence and impact of neuropsychiatric symptoms in normal aging and neurodegenerative syndromes: A population‐based study from Latin America

Cited by 3 publications

References 87 publications

Sex differences in the relationship between depression and Alzheimer’s disease—mechanisms, genetics, and therapeutic opportunities

Sex differences in the relationship between depression and Alzheimer’s disease—mechanisms, genetics, and therapeutic opportunities

Racial/ethnic differences in neuropsychiatric disturbances associated with incident dementia

Cross‐Sectional and Prospective Associations between Parkinsonism and Parkinson's Disease with Frailty in Latin America

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