Prevalence and Impact of Diabetes Mellitus on the Frozen Shoulder

Gundtoft, Per Hviid; Kristensen, Anne Krogh; Attrup, Mikkel Lindegaard; Vobbe, Jette Wessel; Luxhøi, Torben; Rix, Flemming G; Hölmich, Per; Sørensen, Lilli

doi:10.14423/smj.0000000000000886

Cited by 9 publications

(7 citation statements)

References 20 publications

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“…As is commonly known, diabetes mellitus can impair the function and condition of multiple viscera and systems in the human body, [5][6][7][8][9][10] contributing to a variety of diseases, such as coronary artery disease, peripheral vascular disease, and neuropathy. [11] Therefore, diabetes mellitus is currently deemed as the disease that has the most number of complications (more than 100 kinds).…”

Section: Introductionmentioning

confidence: 99%

Prevalence of osteoporosis in patients with type 2 diabetes mellitus in the Chinese mainland

Wang

Guo

et al. 2020

Medicine

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Background: Osteoporosis, as a metabolic disease, has become one of the most rapidly growing complications of diabetes mellitus. Previously, we conducted a systematic review to report the estimated prevalence of osteoporosis among patients with type 2 diabetes mellitus (T2DM) from 2001 to 2016. However, some newer studies have been reported, and more potential risk factors for osteoporosis remain controversial and vague. Therefore, the presented review is tailored to synthesize available evidence regarding the pooled prevalence and related risk factors of osteoporosis among T2DM patients in mainland China.Methods: Both cross-sectional study and cohort study reporting on the prevalence of osteoporosis among patients with T2DM in mainland China, published in Chinese or English, will be considered for inclusion. Records from 4 English databases and 2 Chinese databases will be retrieved from their inceptions to March 2020. The process of study selection, data extraction, and methodologic quality assessment will be independently executed by 2 reviewers. The pooled prevalence of osteoporosis and the prevalence in the exposed and unexposed groups for each potential risk factor will be calculated by the software Stata version 12.0.Results: The current systematic review and meta-analysis will provide more precise prevalence rates and associated risk factors of osteoporosis among people with T2DM in mainland China. Conclusion:The study will offer high-quality and explicit evidence for assisting diabetic patients to prevent osteoporosis in mainland China.

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Section: Introductionmentioning

confidence: 99%

Prevalence of osteoporosis in patients with type 2 diabetes mellitus in the Chinese mainland

Wang

Guo

et al. 2020

Medicine

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“…It has been widely-accepted by some experts that the treatment of diabetic patients with FS compared to that of idiopathic FS is more difficult and they show more resistance to treatment [15][16][17][18][19][20][21][22][23]. However, there have been few well-designed studies of natural history of diabetic FS and comparison of clinical outcomes between diabetic FS and idiopathic FS after conservative treatments [14,24].…”

Section: Discussionmentioning

confidence: 99%

Comparison of Clinical Outcomes between Idiopathic Frozen Shoulder and Diabetic Frozen Shoulder After a Single Ultrasound-Guided Intra-Articular Corticosteroid Injection

2020

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There is no consensus on the use of intra-articular corticosteroid injections in diabetic frozen shoulder (FS). Thus, we aimed to compare clinical outcomes after intra-articular corticosteroid injections in patients with diabetic FS and idiopathic FS. Data collected from 142 FS patients who received glenohumeral joint intra-articular corticosteroid injections were retrospectively reviewed. Thirty-two patients were diagnosed with diabetic FS and 110 patients with idiopathic FS. Data including visual analog scale (VAS) for pain, American Shoulder and Elbow Surgeons (ASES) score, subjective shoulder value (SSV), and passive range of motion (ROM) were compared before the injection and at 3, 6, and 12 weeks after the injection. There were significant improvements in all outcomes (p < 0.001 for all parameters) through 12 weeks in both groups. There were no significant differences in all outcomes, except for ASES scores, between both groups at 3 weeks. However, there were significant differences in VAS score, SSVs, ASES scores, and passive ROMs, except for angle of abduction, between the two groups at 6 weeks and 12 weeks after injection. A single intra-articular steroid injection can be used as a conservative treatment for diabetic FS, but less effective than for idiopathic FS.

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“…The causes of the disease are still unclear. Some mainstream academic views have linked its occurrence and development to the following factors: inflammatory reaction (8)(9)(10)(11), fibrous tissue hyperplasia (12)(13)(14)(15), immune factors (14,16,17), endocrine factors (18)(19)(20), and vascular factors (16,(21)(22)(23). Therefore, identifying the biomarkers and revealing the potential mechanism of AC is the key to the early treatment of AC.…”

Section: Introductionmentioning

confidence: 99%

Role of immune cell infiltration and small molecule drugs in adhesive capsulitis: Novel exploration based on bioinformatics analyses

Liu

Deng

et al. 2023

Front. Immunol.

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BackgroundAdhesive capsulitis (AC) is a type of arthritis that causes shoulder joint pain, stiffness, and limited mobility. The pathogenesis of AC is still controversial. This study aims to explore the role of immune related factors in the occurrence and development of AC.MethodsThe AC dataset was downloaded from Gene Expression Omnibus (GEO) data repository. Differentially expressed immune-related genes (DEIRGs) were obtained based on R package “DESeq2” and Immport database. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) were performed to explore the functional correlation of DEIRGs. MCC method and Least Absolute Shrinkage and Selection Operator (LASSO) regression were conducted to identify the hub genes. The immune cell infiltration in shoulder joint capsule between AC and control was evaluated by CIBERSORTx, and the relationship between hub genes and infiltrating immune cells was analyzed by Spearman’s rank correlation. Finally, potential small molecule drugs for AC were screened by the Connectivity Map database (CMap) and further verified by molecular docking.ResultsA total of 137 DEIRGs and eight significantly different types of infiltrating immune cells (M0 macrophages, M1 macrophages, regulatory T cells, Tfh cells, monocytes, activated NK cells, memory resting CD4+T cells and resting dendritic cells) were screened between AC and control tissues. MMP9, FOS, SOCS3, and EGF were identified as potential targets for AC. MMP9 was negatively correlated with memory resting CD4+T cells and activated NK cells, but positively correlated with M0 macrophages. SOCS3 was positively correlated with M1 macrophages. FOS was positively correlated with M1 macrophages. EGF was positively correlated with monocytes. Additionally, dactolisib (ranked first) was identified as a potential small-molecule drug for the targeted therapy of AC.ConclusionsThis is the first study on immune cell infiltration analysis in AC, and these findings may provide a new idea for the diagnosis and treatment of AC.

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Prevalence and Impact of Diabetes Mellitus on the Frozen Shoulder

Cited by 9 publications

References 20 publications

Prevalence of osteoporosis in patients with type 2 diabetes mellitus in the Chinese mainland

Prevalence of osteoporosis in patients with type 2 diabetes mellitus in the Chinese mainland

Comparison of Clinical Outcomes between Idiopathic Frozen Shoulder and Diabetic Frozen Shoulder After a Single Ultrasound-Guided Intra-Articular Corticosteroid Injection

Role of immune cell infiltration and small molecule drugs in adhesive capsulitis: Novel exploration based on bioinformatics analyses

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