Prevalence and genotyping of hepatitis C virus in blood donors in the state of Pará, Northern Brazil

Filho, Aldemir Branco de Oliveira; Pimenta, Adriana S.C; Rojas, Marcia F.M; Chagas, Márcia Cristina Munhoz; Crescente, José Ângelo Barletta; Crespo, Déborah; Lemos, José Alexandre Rodrigues de

doi:10.1590/s0074-02762010000100016

Cited by 22 publications

(36 citation statements)

References 11 publications

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“…All of the 304 infected donors were invited to participate in this study, and 116 agreed to participate 22 . In addition, we invited 304 uninfected blood donors (anti-HCV antibody-negative and HCV RNA-negative), randomly selected from 241,614 uninfected donors, to participate as a control group 22 ; 140 of them visited the HEMOPA to complete the epidemiological questionnaire. In this way, we selected a total of 256 blood donors in Pará to participate in the research.…”

Section: Resultsmentioning

confidence: 99%

“…The blood donors were selected during routine blood collection at nine hematology and hemotherapy units and in blood-donation campaigns held in public and private institutions in Pará from January 1, 2004-December 31, 2006 22 . As is mandated by Brazilian law 23 , all blood donations obtained at the HEMOPA were voluntary, anonymous, altruistic, and unremunerated, either directly or indirectly.…”

Section: Selection Of Blood Donorsmentioning

confidence: 99%

“…In the State of Pará, the prevalence of anti-HCV ranges from 0.22% to 3.6%, and it is predominantly found in individuals over 50 years old 21,22 . Based on the scarcity of epidemiological information, we decided to determine the risk factors associated with transmission of HCV infection in blood donors in the State of Pará.…”

Section: Introductionmentioning

confidence: 99%

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Likely transmission of hepatitis C virus through sharing of cutting and perforating instruments in blood donors in the State of Pará, Northern Brazil

et al. 2010

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We determined the risk factors for HCV infection in blood donors in the State of Pará, Northern Brazil. We examined 256 blood donors seen at the Blood Bank of Pará State between 2004 and 2006. They were divided into two groups, depending on whether they were infected with HCV or not; 116 donors were infected with HCV, while the other 140 were free of infection. The HCV-RNA was detected by real-time PCR. All of the participants filled out a questionnaire about possible risk factors. The data were evaluated using simple and multiple logistic regressions. The main risk factors for HCV were found to be use of needles and syringes sterilized at home (OR = 4.55), invasive dental treatment (OR = 3.08), shared use of razors at home (OR = 1.99), sharing of disposable razors in barbershops, beauty salons, etc. (OR = 2.34), and sharing manicure and pedicure material (OR = 3.45). Local and regional health authorities should educate the public about sharing perforating and cutting materials at home, in barber/beauty shops, and in dental clinics as risk factors for HCV infection.

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Section: Resultsmentioning

confidence: 99%

Section: Selection Of Blood Donorsmentioning

confidence: 99%

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Likely transmission of hepatitis C virus through sharing of cutting and perforating instruments in blood donors in the State of Pará, Northern Brazil

et al. 2010

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“…The prevalence of HCV infection in illicit drug users sampled in metropolitan areas in the Northeast, Midwest, South and Southeast regions of Brazil ranged from 5% to 36% [3][4][5][6][7] . There are frequent reports of clinical cases of hepatitis or pathologies associated with HCV infection in other population groups in northern Brazil [8][9][10][11] . It is known that most illicit drug users in Pará do not consume injected drugs and are infected with HCV genotype 1 10,11 .…”

mentioning

confidence: 99%

“…Anti-HCV antibodies were tested by enzyme immunoassay (EIA; Murex anti-HCV 4.0, Murex Biotech). HCV RNA was detected by real-time polymerase chain reaction (PCR) using 67 base pairs of the 5' untranslated region (UTR), as described elsewhere 9 . Confi dence intervals (CIs) were determined for infection prevalence estimates.…”

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Prevalence of HCV infection and associated factors among illicit drug users in Breves, State of Pará, northern Brazil

Pacheco

Silva-Oliveira

Maradei-Pereira

et al. 2014

Rev. Soc. Bras. Med. Trop.

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Introduction: Illicit drug users (DUs) are vulnerable to hepatitis C virus (HCV) infection. The shared use of illicit drugs is the main method of HCV transmission. Methods: A cross-sectional study was conducted in Breves, in northern Brazil. We surveyed 187 DUs to determine the prevalence of and factors associated with HCV infection. Results: The prevalence of anti-HCV antibodies was 36.9%, and the prevalence of hepatitis C virus-ribonucleic acid (HCV-RNA) was 31%. Hepatitis C virus infection was associated with tattoos, intravenous drug use, shared use of equipment for drug use, drug use for longer than 3 years, and daily drug use. Conclusions: Strategies for preventing and controlling HCV transmission should be implemented among DUs.Keywords: Hepatitis C virus. Illicit drug users. Northern Brazil.Currently, the sharing of drug paraphernalia is the main transmission method for hepatitis C virus (HCV) worldwide. It is estimated that more than 60% of new HCV infection cases recorded each year are related to the use of illicit drugs, particularly injected drugs 1,2 . In Brazil, epidemiological studies of HCV infection in illicit drug users are still rare. The prevalence of HCV infection in illicit drug users sampled in metropolitan areas in the Northeast, Midwest, South and Southeast regions of Brazil ranged from 5% to 36% 3-7 . There are frequent reports of clinical cases of hepatitis or pathologies associated with HCV infection in other population groups in northern Brazil [8][9][10][11] . It is known that most illicit drug users in Pará do not consume injected drugs and are infected with HCV genotype 1 10,11 . This study estimated the prevalence of HCV infection and assessed the factors associated with HCV infection in illicit drug users in the municipality of Breves, State of Pará, northern Brazil.This cross-sectional study of a non-probabilistic convenience sample was based on information and biological samples provided by illicit drug users in an area of intense illicit drug use located in Breves (01° 40' 55" S 50° 28' 48" O), Archipelago of Marajó, Pará, northern Brazil. Illicit drug users in areas of intense drug consumption were sampled using the snowball technique 11 . Individuals were eligible for the study if they were older than 17 years of age and agreed to answer a specifi c questionnaire and have a blood sample taken and tested for molecular and serologic markers in the period from August to All samples were tested for HCV antibodies and hepatitis C virus-ribonucleic acid (HCV-RNA). Anti-HCV antibodies were tested by enzyme immunoassay (EIA; Murex anti-HCV 4.0, Murex Biotech). HCV RNA was detected by real-time polymerase chain reaction (PCR) using 67 base pairs of the 5' untranslated region (UTR), as described elsewhere 9 . Confi dence intervals (CIs) were determined for infection prevalence estimates. Simple and multiple logistic regressions were calculated to assess the independent effects of variables 12 . The fi t of the fi nal model was assessed using the Hosmer-Lemeshow goodness-of-f...

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Prevalence of viral hepatitis B and C in riverside communities of the Tucuruí Dam, Pará, Brazil

Almeida

Santos

Fecury

et al. 2012

Journal of Medical Virology

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Epidemiologically, the relevance of infection caused by hepatitis viruses is related mainly to their wide geographic distribution and the large number of infected individuals in all parts of the world. In this study, 668 residents from the islands around the Tucuruí Dam were selected. Blood samples were collected for investigation of serological markers (HBsAg, total anti-HBc, anti-HBS, and anti-HCV) by enzyme immunoassays. HCV-positive subjects were tested using RT-PCR and RFLP for the identification of viral genotypes. Among the 668 subjects studied, 1.9% were HBsAg positive, 28% were total anti-HBc positive, and 41.9% were anti-HBs positive. The anti-HBs marker alone (vaccine response) was detected in 25.7% of the volunteers. Anti-HCV antibody was detected in 2.2% of the subjects and genotype 1 was the predominant genotype (70%). The results indicate an intermediate level of HBV and HCV endemicity in the region studied, as well as low HBV vaccination coverage.

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Prevalence and genotyping of hepatitis C virus in blood donors in the state of Pará, Northern Brazil

Abstract: Given the scarcity of epidemiological information on hepatitis C virus (HCV) infection in Northern Brazil

Cited by 22 publications

References 11 publications

Likely transmission of hepatitis C virus through sharing of cutting and perforating instruments in blood donors in the State of Pará, Northern Brazil

Likely transmission of hepatitis C virus through sharing of cutting and perforating instruments in blood donors in the State of Pará, Northern Brazil

Prevalence of HCV infection and associated factors among illicit drug users in Breves, State of Pará, northern Brazil

Prevalence of viral hepatitis B and C in riverside communities of the Tucuruí Dam, Pará, Brazil

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