Prevalence and Genotypic Distribution of Hepatitis C Virus in Peshawar KPK, Pakistan

Kumar, Tarun; Ahmad, Nazir; Hayat, Mian Khizar; Gao, Bao; Faisal, Shah; Ilahi, Nikhat; Ali, Babar; Zada, Sahib; Sajjad, Wasim

doi:10.1016/j.hjb.2017.04.002

Cited by 9 publications

(20 citation statements)

References 24 publications

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“…The results reported by Kumar et al showed that infections with 2a (4.1%) are rare compared to our analysis; frequency of genotype 2a is 12%. Latest study from 2017 demonstrates an increase in the incidence of mixed genotypes and 1a, which is in contrast with the results of this study (48).…”

Section: Hcv Genotype Prevalence In Pakistan 409contrasting

confidence: 99%

“…Egypt surpasses other nations, being the country bearing the highest HCV burden of *14% (73). Of the total population of Pakistan, 6% individuals are infected with HCV, suggesting that viral hepatitis is alarmingly high in general population (48). An estimate suggests that *10 million individuals in Pakistan are infected with HCV, making it a state with second highest HCV burden after Egypt (7).…”

Section: Introductionmentioning

confidence: 99%

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Prevalence of Hepatitis C Virus Genotypes in Pakistan: Current Scenario and Review of Literature

Haqqi

Munir

Khalid³

et al. 2019

Viral Immunology

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Hepatitis C virus (HCV) is a major public health concern globally, resulting in liver-related complications. Approximately 6% population of Pakistan is infected with HCV. HCV is error prone, due to which it is classified into 7 genotypes and 67 subtypes. HCV genotype determination is critical for treatment and therapy response. In this study, 3,539 samples were collected from 2015 to 2019 from all over Punjab. RNA was extracted from samples using QIA Amp Viral RNA MINI kit (Qiagen, Germany) and viral genotyping was performed. Furthermore, a systemized literature search (2009-2018) was done to analyze the HCV genotype distribution pattern in Pakistan. In Punjab, genotype 3a (86.46%) is most prevalent, followed by untypable (7.17%) and genotype 1a (3.84%) and 3b (1.04%). Mixed genotype constitutes only 0.67% of total infections. Genotype 2a, 2b, 3c, and 4 were found to be rare. Data available from literature review when compiled showed that HCV genotype 3a (58.16%) was predominant in Pakistan, followed by genotypes 3b (9.05%), 2a (6.70%), 1a (6.22%), and 1b (2.39%). The frequency of mixed genotypes was found to be 4% and 12% of untypable HCV variants. This study highlights the HCV genotype distribution pattern in different regions of Pakistan. Therapy response and disease management depend on genotype, so HCV genotype determination is crucial. In Pakistan, the most prevalent genotype is 3a, followed by untypable genotype. Both interferon and sofosbuvir are effective against genotype 3a, but treatment with sofosbuvir has comparatively high sustained virological response, less adverse effects, and more tolerability.

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Section: Hcv Genotype Prevalence In Pakistan 409contrasting

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Prevalence of Hepatitis C Virus Genotypes in Pakistan: Current Scenario and Review of Literature

Haqqi

Munir

Khalid³

et al. 2019

Viral Immunology

View full text Add to dashboard Cite

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“…We have also found that the overall percentage was significantly higher in men than women over the last 3 years. This higher prevalence of HCV in male might be due the higher exposure in environment, but HCV is more prevalent among male than females of 2013 and 2017 years (Kumar et al, 2017). Although, epidemiology of HCV exhibit variation from region to region or even (Ahmad et al, 2010;Kumar et al, 2017), reported that 59.9% and 16.5% of individuals were infected with 3a and 1a genotypes, both these being higher percentages than the other genotypes detected.…”

Section: Discussionmentioning

confidence: 93%

“…This higher prevalence of HCV in male might be due the higher exposure in environment, but HCV is more prevalent among male than females of 2013 and 2017 years (Kumar et al, 2017). Although, epidemiology of HCV exhibit variation from region to region or even (Ahmad et al, 2010;Kumar et al, 2017), reported that 59.9% and 16.5% of individuals were infected with 3a and 1a genotypes, both these being higher percentages than the other genotypes detected. Genotype 3a of 34.1% as the most prevalent genotype in district Swat, followed by 2a (8.1%), 3b (7%), 1a (5.4%) and mixed genotype 7.6% (Inamullah et al, 2011).…”

Section: Discussionmentioning

confidence: 93%

“…Previously, rare studies have been undertaken in different regions of Pakistan (Ahmad et al, 2007;Aslam and Aslam, 2001;Kumar et al, 2020Kumar et al, , 2017. Thus, urging needs to study the relationship between HCV and population-based on their route of entry, age, and gender with their overall HCV genotypes in Pakistan.…”

Section: Prevalence Of Active Hcv Infection and Genotypic Distribution Among The General Population Of District Mardan Pakistanmentioning

confidence: 99%

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Prevalence of active HCV infection and genotypic distribution among the general population of district Mardan, Pakistan

et al. 2023

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Hepatitis C virus (HCV) is the serious global public health burden of liver disease. Approximately 170 million people in the world are infected with (HCV). In Pakistan, where the disease has high occurrence rate. The present study envisages an up-to-date prevalence of HCV and genotypic distribution in the general population of Mardan District, Khyber Pakhtunkhwa (KP), Pakistan. The blood samples from 6,538 individuals including 3,263 males and 3,275 females were analyzed for hepatitis C surface antigen by Immuno-chromatographic test (ICT), Enzyme-linked immunosorbent assay (ELISA), and reverse transcription-polymerase chain reaction (PCR). It was found that 396 (12.13%) out of 3263 individuals contained antibodies in their blood against HCV, while among the different age groups, the highest incidences of HCV antibodies were found in the 31-40 age group (11.01%). The ICT positive samples were further screened by nested PCR to determine the existence of active HCV-RNA. It was identified that 7.11% (3263) of the total population (6538) tested was positive, among which the 461 (14.07%) females possessed antibodies in their blood against HCV. Our data showed total HCV infection in the investigated population was 5.78%. Higher percentage of HCV prevalence was detected in males than females in the age group 31-40 and 41-50. To compare the prevalence of HCV genotypes age-wise in male and female genotype 3a was found most prevalent genotype followed by 1a, 2a and 3b, respectively.

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Molecular evolution, virology and spatial distribution of HCV genotypes in Pakistan: A meta-analysis

Habib,

Anjum

et al. 2023

Infectious Medicine

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Prevalence and Genotypic Distribution of Hepatitis C Virus in Peshawar KPK, Pakistan

Cited by 9 publications

References 24 publications

Prevalence of Hepatitis C Virus Genotypes in Pakistan: Current Scenario and Review of Literature

Prevalence of Hepatitis C Virus Genotypes in Pakistan: Current Scenario and Review of Literature

Prevalence of active HCV infection and genotypic distribution among the general population of district Mardan, Pakistan

Molecular evolution, virology and spatial distribution of HCV genotypes in Pakistan: A meta-analysis

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