Prevalence and Genotypes of Hepatitis G Virus among Hemodialysis Patients in Eastern Anatolia, Turkey

Özdarendeli, Aykut; Toroman, Z. A.; Kalkan, Ahmet; Kılıç, Süleyman; Özden, Mehmet; Doymaz, Mehmet Ziya

doi:10.1159/000083920

Cited by 10 publications

(18 citation statements)

References 45 publications

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“…Previous studies revealed that GBV-C genotype 1 was prevalent mainly in Ghana, Zaire and West Africa; genotype 2 in the USA, Spain, Egypt, Nepal, Thailand, India, Turkey, Saudi Arabia, Pakistan, UAE and Myanmar; genotype 3 in Japan, Philippines and Bolivia; genotype 4 in Vietnam, Myanmar and Cambodia; genotype 5 in South Africa [Smith et al, 1997;Naito et al, 1999;Al-Ahdal et al, 2000;Tucker and Smuts, 2001;Abraham et al, 2002;Abu Odeh et al, 2005;Ozdarendeli et al, 2005] and genotype 6 in Indonesia [Handajani et al, 2000;Muerhoff et al, 2006]. Phylogenetic analysis of our samples revealed that all GBV-C isolates were genotype 2, and classified as subtype 2a.…”

Section: Discussionmentioning

confidence: 98%

Frequency and genotype of GB virus C among Iranian patients infected with HIV

Hekmat

Mohraz

Vahabpour

et al. 2008

Journal of Medical Virology

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GB virus C (GBV-C) infection is frequent in patients infected with the human immunodeficiency virus (HIV) due to similar transmission routes of these viruses. The aim of this study was to determine the rate of infection and genotypic characteristics of GBV-C in this population. The presence of GBV-C RNA was determined in serum samples of 106 patients infected with HIV by reverse transcriptase-nested polymerase chain reaction. GBV-C genotypes were determined by direct sequencing. Hepatitis B surface antigen (HBsAg), hepatitis B surface antibody (anti-HBs), hepatitis C antibody (anti-HCV), alanine aminotransferase (ALT) levels, HIV viral load and CD4(+) count were also tested in all patients. The overall prevalence of GBV-C infection was 11.3% in HIV patients. There was no significant difference between patients with and without GBV-C infection regarding age, sex, route of transmission, viral load, ALT levels, HBV and HCV co-infection and treatment with antiretroviral drugs. 66.7% of patients with GBV-C had a CD4(+) count > or = 200 and 33.3% had a CD4(+) count < 200 cells/mm(3). Phylogenetic analysis revealed that all GBV-C isolates were genotype 2, and classified as subtype 2a. GBV-C infection is relatively common in patients infected with HIV. The prevailing GBV-C genotype 2a in this study group concurred with reports from other parts of the Middle East.

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Section: Discussionmentioning

confidence: 98%

Frequency and genotype of GB virus C among Iranian patients infected with HIV

Hekmat

Mohraz

Vahabpour

et al. 2008

Journal of Medical Virology

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“…Kan ve kan ürünleri ile parenteral yolla bulaşabilen hepatit G ve TTV prevalansının hemodiyaliz hastalarında sağlıklı bireylerden daha yüksek olduğu bildirilmiştir [12][13][14][15][16][17].…”

Section: Discussionunclassified

“…Hemodiyaliz hastalarında hepatite neden olan hepatit E (HEV), Hepatit G (HGV) , transfüzyonla bulaşan virus (TTV) viruslerinin sıklığına ilişkin çeşitli çalışmalar yapılmıştır ve Transfusion transmitted virus (TTV)'un bulaş yolu tam olarak aydınlatılamasa da, hemodiyaliz hastalarında TTV seroprevalansı %9,3-83 arasında değişmektedir [3][4][5][6][7][8][9][10][11][12][13].…”

Section: Introductionunclassified

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The seroprevalance of hepatitis E, hepatitis G and TTV in haemodialysis patients

et al. 2017

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ÖzAmaç: Hemodiyaliz hastaları kan, kan ürünleri, perkütan yaralanma veya fekal-oral yolla bulaşabilen hepatit virüs-leri açısından risk grubunda yer alır. Bu çalışmada, hemodiyaliz hastalarında Hepatit E, Hepatit G ve TTV seropozitifliğinin belirlenmesi amaçlandı. Gereç ve Yöntemler:Çalışmaya 66 hemodiyaliz hastası (30 kadın, 36 erkek) ve 66 kontrol (43 kadın, 23 erkek) olmak üzere toplam 132 kişi dahil edildi. Çalışmada anti-HEV, anti HGV ve anti-TTV IgG düzeyleri ELISA yöntemi ile çalışıldı. İstatistiksel analizler SPSS programı ile yapıldı. Elde edilen sonuçların istatistiksel değerlendirilme-sinde Students t testi, Fischer exact testi ve Mann Whitney-U testleri kullanıldı. P < 0.05 değeri istatistiksel olarak anlamlı kabul edildi. Bulgular: Çalışmaya alınan 66 hasta ve 66 sağlıklı kontrol grubunun yaş ortalaması sırasıyla; 54,9 ve 47,2 idi. Hasta ve kontrol grubunun yaş ortalaması karşılaştırıldığında hasta grubunun yaş ortalaması daha yüksekti.Anti-TTV IgG ve anti-HEV IgG pozitifliği hemodiyaliz hastalarında kontrol grubuna göre daha yüksek bulundu. Hasta ve kontrol grubunda anti-HGV IgG pozitifliği tespit edilmedi. Hemodiyaliz hasta grubunda anti-TTV IgG ve anti-HEV IgG pozitifliği ile hemodiyaliz süresi, yaş ve cinsiyet arasında istatistiksel olarak anlamlı bir ilişki saptanmadı.Sonuç: Hemodiyaliz hastaları, TTV, hepatit E virüsü ve diğer hepatit virüslerinin bulaşı açısından yüksek risk taşırlar. Bu nedenle, hemodiyaliz ünitelerde temizlik ve dezenfeksiyon kurallarına uyulması HEV ve TTV gibi hepatit virüslerinin bulaşını önlemek için gereklidir.

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“…These conflicting results may be related to various factors such as the GBV‐C/HGV infection rate in the general population, the size of the study group, the methods used to detect the GBV‐C/HGV, and the demographic and clinical features of the patients (23). Regarding HD patients, the HGV prevalence ranges from 3% to 57% in transversal studies (15,24–26). In a preliminary report from Iran, a rate of 28.6% of GBV‐C infection was reported among a group of patients (chronic hepatitis, kidney transplant, and volunteer blood donors).…”

Section: Discussionmentioning

confidence: 99%

Hepatitis G Virus Exposure in Dialysis Staff

Eslamifar

Hamkar²,

Ramezani

et al. 2007

Ther Apher Dial

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Hepatitis G virus (HGV) is a blood-borne virus. Some present data demonstrate an occupational risk of HGV infection in medical staff of dialysis units. The aim of this investigation was to assess the prevalence of HGV exposure in dialysis staff. This study was performed in a main dialysis unit in Iran. In 27 dialysis staff, HGV exposure was detected serologically by the presence of anti HGV envelope protein E2 (anti-E2) by an enzyme-linked immunosorbent assay, and compared with 77 hemodialysis (HD) and 13 continuous ambulatory peritoneal dialysis (CAPD) patients. All of them were also screened for hepatitis B surface antigen (HBsAg), hepatitis B surface antibody (anti-HBs), and hepatitis C antibody (anti-HCV). A low prevalence of HGV exposure was found in the dialysis staff (0%), which nearly corresponded to the prevalence of the dialysis patients (HD 3.89%, CAPD 0%). The prevalence of anti-HCV and anti-HBs in staff was 37.03% and 33.33%, respectively, which was higher than HGV anti-E2. The prevalence of HGV exposure was low in dialysis staff in our study, and was near to the prevalence of HGV exposure in dialysis patients. Therefore, it can be concluded that the occupational risk for HGV exposure in our investigation was minimal.

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Prevalence and Genotypes of Hepatitis G Virus among Hemodialysis Patients in Eastern Anatolia, Turkey

Cited by 10 publications

References 45 publications

Frequency and genotype of GB virus C among Iranian patients infected with HIV

Frequency and genotype of GB virus C among Iranian patients infected with HIV

The seroprevalance of hepatitis E, hepatitis G and TTV in haemodialysis patients

Hepatitis G Virus Exposure in Dialysis Staff

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