Prevalence and Genotype Distribution of Human Papillomavirus From 9,182 Individuals Participated Health Examination

Zhang, Chao; Xie, Chunbao; Du, Qiong; Hu, Hong-Hua; Liu, Xiang-Qin; Long, Juan; Zhong, Jialing; Jiang, Wei

doi:10.7754/clin.lab.2019.190937

Cited by 1 publication

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“…Our study showed that the overall HR-HPV prevalence among women aged 35-64 years in Chengdu was 11.7%, with an HPV 16/18 infection rate of 1.4%. These findings were consistent with previous studies conducted by He et al (12.6%, 1.7%) and Zhang et al (13.2%, 1.3%) on the prevalence of HPV infection in Sichuan Province [13,14]. We noted that the proportion of HPV 16/18 infections in women aged 35-64 years accounted for only 12.06% of the HR-HPV-positive population, which was attributed to the fact that HPV 52 and 58 were the predominant genotypes in the general population in Sichuan province, whereas HPV 16/18 had a higher proportion of infections in patients with cervical lesions, especially in high-grade lesions [15][16][17][18][19].…”

Section: Screening Findings About Hpv Infection and Cervical Lesionssupporting

confidence: 93%

Real-world effectiveness of cytology and HPV-based screening strategy in cervical cancer screening: A cross-sectional population-based study in Chengdu, China

Yao,

Peng,

Song

et al. 2024

PLoS ONE

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Cervical cancer poses a significant health challenge in developing countries, emphasizing the need for appropriate screening strategies to accelerate the elimination of this disease. This study summarized the results of a large-scale community-based cervical cancer screening program conducted in Chengdu, China, to understand the prevalence of HPV infection and cervical lesions in the population, and to compare the real-world effectiveness of two different screening methods implemented in the program. From January 2021 to December 2022, a total of 363,376 women aged 35–64 years in Chengdu received free screenings. Among these participants, 70.1% received cytology screening and 29.9% received HPV testing combined with 16/18 genotyping and cytology triage. Ultimately, 824 cases of high-grade lesions and cervical cancer were detected, with a total detection rate of cervical cancer and precancerous lesions of 226.8 per 100,000. The follow-up rate of patients with high-grade lesions and above was 98.9%, and the treatment rate was 86.6%. The overall high-risk HPV infection rate was 11.7%, with the HPV 16/18 infection rate of 1.4%. The rate of abnormal cytology results was 2.8%. The attendance rates for colposcopy and histopathology were 71.6% and 86.1%, respectively. By calculating the age-standardized rates to eliminate the different age composition between the two group, the HPV-based screening strategy had a higher rate of primary screening abnormalities (3.4% vs. 2.8%, P<0.001), higher attendance rates of colposcopy (76.5% vs. 68.9%, P<0.001) and histopathological diagnosis (94.1% vs. 78.0%, P<0.001), higher percentage of abnormal colposcopy results (76.0% vs. 44.0%, P<0.001), and higher detection rate of cervical precancerous lesions and cancer (393.1 per 100,000 vs. 156.4 per 100,000, P<0.001) compared to cytology screening. Our study indicates that the combination of HPV testing with 16/18 genotyping and cytology triage has demonstrated superior performance in cervical cancer screening compared to cytology alone in large-scale population.

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Section: Screening Findings About Hpv Infection and Cervical Lesionssupporting

confidence: 93%

Real-world effectiveness of cytology and HPV-based screening strategy in cervical cancer screening: A cross-sectional population-based study in Chengdu, China

Yao,

Peng,

Song

et al. 2024

PLoS ONE

View full text Add to dashboard Cite

show abstract

Prevalence and Genotype Distribution of Human Papillomavirus From 9,182 Individuals Participated Health Examination

Cited by 1 publication

References 0 publications

Real-world effectiveness of cytology and HPV-based screening strategy in cervical cancer screening: A cross-sectional population-based study in Chengdu, China

Real-world effectiveness of cytology and HPV-based screening strategy in cervical cancer screening: A cross-sectional population-based study in Chengdu, China

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