Prevalence and genotype distribution of human papillomavirus in non‐neoplastic cervical tissue lesion: Cervical erosion

Abstract

Human papillomavirus (HPV) infection is the commonest sexually transmitted infection, which is associated with various clinical conditions, ranging from asymptomatic infection to malignant disease of the cervix. The aim of this study was to evaluate the prevalence and genotypic distribution of HPV in women with cervical erosion and to compare the results with those in women with a clinically normal cervix. A further aim was to establish the association between HPV infection and cervical cytology results in women with and without cervical erosion. Cervical samples were collected by liquid-based method and consecutively evaluated for the presence of HPV DNA and for cervical cytology. HPV DNA was tested by a nested polymerase chain reaction (PCR) and typed by reverse dot blot genotyping. Cytological classification was made according to Bethesda 2001 criteria. The overall HPV prevalence was 16.9%; HPV DNA was positive in 20.2% of women with cervical erosion and 12.8% in women with normal cervix (P < 0.05). Multiple infections were found in 34.1% of the HPV-positive women. Commonest types were HPV 18 (32.9%), HPV 16 (29.5%), HPV 54 (20.5%), and HPV 6 (17%). Cervical cytology results were abnormal for 5.2% of women with cervical erosion and for 1.3% with clinically normal cervix (P < 0.05). This study detected a high prevalence of HPV infection in women with cervical erosion compared to women with a normal cervix. This data may contribute to the HPV epidemiology in the southeastern Turkey. It is recommended that women with cervical erosion should be given priority in HPV screening programs.

Nuclear expression of Rac1 in cervical premalignant lesions and cervical cancer cells

“…We also found moderate-strong reactivity for the five proteins in samples without SIL (Table 1). Recent evidences demonstrate infection with HR-HPVs in patients without SILs [40-42]. It is possible that some of the samples without SIL that showed moderate-strong reactivity are positive to HR-HPV.…”

Human Papillomavirus Infection and Vaginal Tape Exposure after Midurethral Sling: A Case Report

“…HPV is the commonest sexually transmitted infection which is associated with many clinical conditions varying from asymptomatic infection to malignant disease of the cervix. Condylomata acuminata have been related to cervical erosion [5]; in fact, Bayram et al [5] detected a high prevalence of HPV infection in women with cervical erosion compared to women with a normal cervix. In our case, no risk factors of vaginal erosion were present except an HPV infection.…”

Distribution of uterin cervical lesions and relation between age and parity rates in the mardin province

“…HPV DNA was positive in 16.9% of the women overall and in 15.1% of women with normal cervical cytology as the rates in newer studies from Turkey (13,14). The most common genotypes in HPV infected women were HPV 18 and HPV 16, which are also the most commonly detected types worldwide.…”

“…Other common types were HPV 54, 6, 58 and 59 among the female population in Gaziantep province. According to that study, there was a significant association between abnormal cervical cytology and having cervical erosion regardless of HPV infection (13). We had been working in that hospital while we served our compulsory services and the Pathology unit consisted of only a cytology laboratory.…”