Prevalence and genotype distribution of high‐risk human papillomavirus in 34 420 cases in Yangzhou city, Jiangsu province, China

Li, Yuwu; Liu, Xiaoli; Han, Chongxu; Ren, Chuanli

doi:10.1002/jmv.27012

Cited by 6 publications

(9 citation statements)

References 38 publications

(64 reference statements)

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“…That China is vast in territory and huge in population, coupled with unbalanced development, and insufficient awareness of prevention and screening in earlier years and nonstandard cervical cancer screening in certain underdeveloped areas resulted in the regional differences in the epidemiology of HPV and cervical cancer. The overall infection rate of hrHPV in different regions of China was 8.8%-25.7% in recent years [4][5][6][19][20][21][22][23][24][25]. Our study showed that the overall infection rate of hrHPV was 20.3%, which was similar to most reviews or researches on the nationwide prevalence of hrHPV infection in China [4][5][6].…”

Section: Discussionsupporting

confidence: 83%

Extensive HPV Genotyping Reveals High Association between Multiple Infections and Cervical Lesions in Chinese Women

Zhong

et al. 2022

Disease Markers

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Objective. The relationship between human papillomavirus (HPV) and cervical lesions has been extensively elucidated, but infection with multiple genotypes is less investigated due to methodology limitations. In the current study, with a method of genotyping 21 HPVs in a routine cervical screening population, we aimed to investigate the prevalence and diversity of HPV infections in Chinese women and further evaluate the impact of multiple infections of HPV on cervical lesion progression. Methods. Totally, 73,596 patients who underwent 21-genotype HPV testing from January 2018 to April 2019 were retrieved from the database of the Department of Pathology, Obstetrics and Gynecology Hospital of Fudan University. HPV testing was performed by real-time PCR assay, including 13 high-risk HPVs (hrHPV), 5 potential hrHPVs, and 3 low-risk HPVs. Results. Of the 17,079 (infection rate, 23.2%) hrHPV- or potential hrHPV- (hr/phrHPV-) positive cases, 26.3% had multiple infections. Women younger than 25 and older than 65 were more prone to multiple infections. Of the hr/phrHPV-positive cases involving cervical intraepithelial neoplasia (CIN) 2 or worse (CIN2+), HPV73, 53, and 66 (=59) were the top three genotypes most likely to be included in multiple infections, while HPV16, 18, and 58 were the 3 least. Patients with single infection of HPV16 had higher incidences of CIN2+ than those with multiple-infection pattern ( P < 0.001 ), indicating that mixing with other genotypes alleviated pathogenicity. The infection of HPV52, 53, 56, 51, 39, 66, 59, 68, and 35 showed an opposite pattern, indicating that they were less likely to be pathogens individually. All other types showed no significant differences, indicating the capability of pathogenesis independently. HPV26 showed a higher OR for CIN2+ than most traditional hrHPV genotypes. The vial load and the percentage of HPV16 showed positive correlation with the severity of cervical lesions. Conclusion. Extensive genotyping identified 3 most frequent genotypes, HPV16, 52, and 58, in CIN2+ of Chinese population. HPV16 mixing with other genotypes alleviated its pathogenicity. The vial load and the percentage of HPV16 were positively correlated with the severity of cervical lesions. HPV26 may be considered as a hrHPV, which needs to be evaluated and confirmed by more cases.

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Section: Discussionsupporting

confidence: 83%

Extensive HPV Genotyping Reveals High Association between Multiple Infections and Cervical Lesions in Chinese Women

Zhong

et al. 2022

Disease Markers

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“…The HR-HPV infection rate is also different in various regions of China. Our frequency of HR-HPV infection (15.33%) is lower than that previously reported in Fujian (18.68%) [ 20 ], Yangzhou (23.56%) [ 21 ], and Guangzhou (21.12%) [ 7 ], higher than that previously reported in Sichuan (12.6%) [ 22 ], Xinjiang (9.72%) [ 9 ], and Beijing (7.0%), and similar to that reported in Shanghai (15.56%) [ 8 ].…”

Section: Discussioncontrasting

confidence: 81%

The prevalence and genotype distribution of human papillomavirus among women in Guangxi, southern China

Liu-ting

Qin

et al. 2022

Infect Agents Cancer

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Background Human papillomavirus is a primary cause of cervical cancer and genital warts. HPV vaccine can prevent high-grade cervical lesions as well as cervical cancer. The aim of this study was to analyze the prevalence and genotype distribution of human papillomavirus among women in Guangxi before and after the HPV vaccine was approved for use in China. Methods From January 2016 to May 2021, 41,140 women were tested for HPV infection. HPV genotyping included 15 high-risk HPV (HR-HPV) and 6 low-risk HPV (LR-HPV) genotypes. Total prevalence, annual trend, and specific age group prevalence and genotype distribution were analyzed. Results The overall HPV infection rate was 18.10% among Guangxi women self-referred to clinic for gynecologic problems in southern China. During 2016–2018, the prevalence of HPV infection showed an upward trend, from 18.21% in 2016 to 21.99% in 2018, and later it showed a downward trend, from 18.35% in 2019 to 12.26% in May 2021. Pure HR-HPV genotypes (14.36%) were found in more infections than pure LR-HPV genotypes (2.77%) and mixed genotypes (0.97%). Two peaks of HPV infection were found in the ≤ 25 years (22.94%) and 56–65 years (21.25%) groups. The six most prevalent HR-HPV genotypes were HPV 52 (4.06%), 16 (2.70%), 58 (2.24%), 51 (1.87%), 39 (1.52%), and 53 (1.52%). The three most prevalent LR-HPV genotypes were HPV 6 (1.31%), CP8304 (1.01%), and 11 (0.82%). Infection with a single HR-HPV genotype was the most common type of infection, with an overall infection rate of 12.30%. Infection with two HPV genotypes was the most common multiple HR-HPV infection type, with an infection rate of 2.35%. Conclusions The cervical HPV infection rate of women in Guangxi is very high, and there is significant age specificity. There is a need to increase HPV vaccination of young people and the screening of middle-aged and elderly people.

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“…In our study, the most common genotype was HPV-52, followed by HPV-16, -58, -53 and -39, which was consistent with the result in Guizhou [ 41 ]. HPV-52, -58, -16, -51 and -39 were the five most common HR-HPV genotypes in Yangzhou [ 42 ], and HPV-52, -16, -58, -39 and -51 in Wuhan [ 43 ]. It has been reported that HPV-52 and -58 were the more prevalent genotypes in Asia, especially in China, and infection with them may have association with the cervical cancer development [ 38 , 44 ].…”

Section: Discussionmentioning

confidence: 99%

Prevalence of cervicovaginal human papillomavirus infection and genotype distribution in Shanghai, China

Xiang

Dai

et al. 2022

Virol J

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Background The evaluation of human papillomavirus (HPV) prevalence rate dynamics and genotype distribution could support the adoption of more targeted prevention and treatment of cervical cancer. We aimed to assess the infection status and genotype characteristics of HPV among gynecological outpatients in Shanghai, China. Methods Clinical specimens were collected from patients attending gynaecological department of the Putuo Hospital, Shanghai University of Traditional Chinese Medicine, between January 2015 and December 2019. The cervicovaginal infection of 17 high-risk genotypes and 10 low-risk genotypes were analyzed by Luminex-based multiple assays. Results The overall HPV infection rate was 18.81% (95% CI 18.31–19.30%) in Shanghai city, with high-risk, low-risk and mixed high- and low-risk HPV prevalence being 11.65% (95% CI 11.24–12.06%), 4.19% (95% CI 3.94–4.44%) and 2.96% (95% CI 2.74–3.17%), respectively. The five most prevalent high-risk genotypes were HPV-52 (2.95%), HPV-16 (2.34%), HPV-58 (2.07%), HPV-53 (1.67%) and HPV-39 (1.36%). The most common low-risk genotype was HPV-61 (1.52%), followed by HPV-6 (1.29%) and HPV-81 (1.19%). Moreover, the coverage of HPV genotype by nonavalent vaccine was 10.42%, and non-vaccine-covered high-risk genotype was 7.70%. The 15–24 years age group demonstrated the highest HPV prevalence (43.14%), and significant differences were observed among different age groups (P < 0.001). Conclusions This study revealed the HPV prevalence and genotype distribution among women in Shanghai city, which could serve as guidance for HPV vaccination and preventative strategies against cervical cancer in this area.

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Prevalence and genotype distribution of high‐risk human papillomavirus in 34 420 cases in Yangzhou city, Jiangsu province, China

Cited by 6 publications

References 38 publications

Extensive HPV Genotyping Reveals High Association between Multiple Infections and Cervical Lesions in Chinese Women

Extensive HPV Genotyping Reveals High Association between Multiple Infections and Cervical Lesions in Chinese Women

The prevalence and genotype distribution of human papillomavirus among women in Guangxi, southern China

Prevalence of cervicovaginal human papillomavirus infection and genotype distribution in Shanghai, China

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