Prevalence and genotype distribution of cervical human papillomavirus infection: Comparison between pregnant women and non‐pregnant controls

Chan, Paul K.S.; Chang, Alexander R.; Tam, Wing Hung; Cheung, Jo L.K.; Cheng, A. F. B.

doi:10.1002/jmv.10142

Cited by 57 publications

(54 citation statements)

References 36 publications

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“…Several reports show that the prevalence of HPV infection in pregnant women is variable at 10-60%, depending on age, region and HPV detection methods. [11][12][13][14] The HPV infection rate in pregnant women in this report was 35%. There are few reports of HPV infection rates in pregnant Japanese women.…”

Section: Discussionmentioning

confidence: 50%

Epidemiology of human papillomavirus genotypes in pregnant Japanese women

et al. 2011

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To investigate the pre-vaccination epidemiology of genital human papillomavirus (HPV) infections and genotypes in pregnant Japanese women, we performed Pap smear tests and HPV genotype testing in patients attending Nagasaki University Hospital and collaborating hospitals from August 2007 to July 2010. Serial uterine cervical specimens were obtained from 151 pregnant women. The HPV test was positive on the first visit in 54 women (35.8%; 54/151, average age 30). A total of 49 women (32.5%; 49/151) were infected by at least one high-risk HPV and 5 women were infected by only low-risk HPV. The three most prevalent high-risk HPV genotypes were HPV 52 (31.5%; 17/54), HPV 16 (29.6%; 16/51) and HPV 31 (13.0%; 7/51). The HPV infection pattern (negative, single infection and multiple infection) differed significantly according to the pregnancy trimester (v 2 -test; Po0.01(Pearson)). Among HPV-infected pregnant Japanese women, HPV52 was the most common genotype. The second most common genotype was HPV16, and these two genotypes accounted for B60% of HPV-positive pregnant women. Infection with multiple HPV genotypes was observed more frequently in the first trimester of pregnancy and the pattern of infection changed significantly depending on pregnancy stage. (2011) 56, 313-315; doi:10.1038/jhg.2011 published online 10 February 2011 Keywords: epidemiology; genotype; HPV; infection; pregnancy; uterine cervical neoplasia INTRODUCTION Persistent infections with human papillomavirus (HPV) are recognized as a major cause of cervical cancer. Genital infections with HPV are very common, and these infections are transmitted by sexual contact. 1 In most cases, HPV infections disappear naturally in a relatively short time period and carry only a small risk of disease development; 2-4 however, some investigators believe that pregnancy affects the host immune system; for example, pregnancy is believed to reduce seroreactivity against HPV infection. 5 Estrogen and progesterone have been shown to activate the upstream regulatory region of HPV18 (see ref. 6). Thereby altering HPV clearance rates compared with non-pregnant women. During persistent infection, important factors of disease susceptibility include HPV genotypes and viral characteristics, such as the distribution of each type in the population and the evasive ability against the host's immune system. It is not clear how persistent infection relates to the host, such as how the host immune system reacts against a specific HPV genotype and how sexual behavior in pregnant women affects infection rates. In particular, there are very few data detailing HPV genotype prevalence in pregnant Japanese women. To determine the distribution of HPV infections in pregnant Japanese women, we performed HPV genotype testing. Journal of Human Genetics MATERIALS AND METHODS Study population and sample collectionCytology and HPV DNA test samples were collected by six hospitals that collaborated with Nagasaki University Hospital from August 2007 to July 2010. All pregnant women whose first visit ...

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Section: Discussionmentioning

confidence: 50%

Epidemiology of human papillomavirus genotypes in pregnant Japanese women

et al. 2011

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“…It is well known that high risk HPV infections are more frequent in pregnant women. [7][8][9] The polymerase chain reaction (PCR) technology for CMV, HSV, HPV detection is now highly sensitive and can detect viral DNA in exfoliated cells irrespective of the sampling method used. 10 The aim of this study was to detect CMV, HSV-2, and HPV type 16-18 from cervical smear samples of pregnant women by PCR based methods and to improve an algorithm for follow-up of positive patients.…”

Section: Introductionmentioning

confidence: 99%

Molecular detection of cytomegalovirus, herpes simplex virus 2, human papillomavirus 16-18 in Turkish pregnants

Dinç¹,

Bozdayı²,

Bırı³

et al. 2010

Braz J Infect Dis

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Objective: Human cytomegalovirus (CMV) is the most common cause of viral intrauterine infections in the world. Herpes simplex virus type 2 (HSV-2) and human papillomavirus (HPV) are the main agents of viral sexually transmitted diseases, which cause genital ulcers and genital warts, respectively. HPV infection has been linked to the majority of the anogenital malignancies. The aim of this study was to detect the existence of CMV, HSV-2 and HPV type 16-18 in Turkish pregnants by using sensitive molecular assays. Methods: One hundred thirty-four women (18-41 years old; mean age ± SD: 27 ± 8) applied to outpatient clinic of Obstetrics and Gynecology, in between 18th -22nd weeks of their pregnancy and a control group of 99 healthy women (15-39 years old; mean age ± SD: 24 ± 8) were included in the study. Cervical smear samples were used for DNA extraction. CMV, HSV-2 and HPV 16-18 detections were carried out by real time PCR and in house PCR method, respectively. Results: Three patients (3/134; 2.2%) were found to be positive for each HPV and HSV-2. Dual infection with HPV and HSV was found in just one patient. HPV 18 was detected in all positive samples. CMV was found to be positive in two patients (2/134; 1.4 %). Conclusion: HPV, HSV and CMV must be screened due to high prevalence of these viruses in pregnants by using sensitive molecular methods.

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“…A grande variação -de 5% a 59% -na prevalência da infecção genital por HPV no período gestacional observada em estudos anteriores (ChangClaude et al, 1996;Tenti P et al, 1999;Eppel et al, 2000;Chan PK et al, 2002;Smith EM et al, 2004;Takakuwa et al, 2006;Banura et al, 2008b) pode ser explicada por alguns fatores como: avaliação de gestantes oriundas de populações com grandes diferenças na prevalência dessa infecção, pela menor sensibilidade dos testes empregados para a detecção do DNA-HPV nos estudos iniciais, pela utilização de diferentes tipos de amostras para a detecção do DNA viral -coletadas em diversas fases do período gestacional -e, ainda, pela inclusão de gestantes pertencentes a grupos etários distintos.…”

Section: Mais Da Metade Das Mulheresunclassified

“…Para alguns autores, não houve diferença significativa na prevalência da infecção por HPV entre gestantes e não gestantes (Kemp, 1992;Chang-Claude, 1996;Chan, 2002). Também não se obteve diferença estatisticamente significante na prevalência da infecção por HPV em gestantes e em não gestantes, pareadas por idade, em Hong Kong-China, país com baixa incidência de câncer cervical, onde se observou baixa prevalência, respectivamente 10% e 11%, nesses dois grupos (Chan et al, 2002).…”

Section: Introductionunclassified

“…Também não se obteve diferença estatisticamente significante na prevalência da infecção por HPV em gestantes e em não gestantes, pareadas por idade, em Hong Kong-China, país com baixa incidência de câncer cervical, onde se observou baixa prevalência, respectivamente 10% e 11%, nesses dois grupos (Chan et al, 2002). A grande variação na prevalência da infecção pelo HPV observada em gestantes, com valores oscilando de 5% a 59% (Chang-Claude et al, 1996;Tenti P et al, 1999;Eppel et al, 2000;Chan et al, 2002;Smith et al, 2004;Takakuwa et al, 2006;Banura et al, 2008b) pode ser explicada por inúmeras diferenças nos desenhos utilizados nos diferentes estudos. Nestes, foram empregadas múltiplas técnicas de biologia molecular com variação na sensibilidade para a detecção do DNA viral, além da avaliação de gestantes pertencentes a populações com grandes diferenças na prevalência dessa infecção (Arena et al, 2002).…”

Prevalence and genotype distribution of cervical human papillomavirus infection: Comparison between pregnant women and non‐pregnant controls

Cited by 57 publications

References 36 publications

Epidemiology of human papillomavirus genotypes in pregnant Japanese women

Epidemiology of human papillomavirus genotypes in pregnant Japanese women

Molecular detection of cytomegalovirus, herpes simplex virus 2, human papillomavirus 16-18 in Turkish pregnants

Prevalência de infecção por HPV em jovens primíparas e fatores associados

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