Prevalence and genotype distribution of human papillomavirus infection in different anatomical sites among men who have sex with men: A systematic review and meta‐analysis

Farahmand, Mohammad; Monavari, Seyed Hamidreza; Tavakoli, Ahmad

doi:10.1002/rmv.2219

Cited by 24 publications

(38 citation statements)

References 172 publications

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“…A systematic review and meta-analysis found that overall prevalence of anal, penile, and oral HPV infection among men who have sex with men were 78.4%, 36.2%, and 15.4%, respectively, with higher rates in HIV-positive than HIV-negative MSM. The most frequent HPV high-risk type detected in the anus, penis, and oral cavity was HPV 16 (19.9%, 4.9% and 3.1%, respectively) 38 .…”

Section: Discussionmentioning

confidence: 99%

Sexual practices and HPV infection in unvaccinated young adults

Pauli

Kops²,

Bessel³

et al. 2022

Sci Rep

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The present study aimed to evaluate the association of genital and oral HPV infection among different sexual practices in both sexes. In total, 6388 unvaccinated men and women aged 16–25 years from all state capitals of Brazil were enrolled in through primary care services between September 2016 and November 2017. Genital and oral HPV genotyping was performed using the Roche Linear Array. Poisson regression analysis with robust variance was conducted to examine factors associated with overall HPV infection. A higher prevalence of genital HPV was found in women who practiced oral sex (57.85%) and in men who practiced all types of sex (65.87%). However, having more sexual partners and being younger were more important than the type of sex practiced. HPV 6 (7.1%) and 16 (10.5%) were significantly more prevalent in women who practiced oral sex, while HPV 6 (23.96%) and 11 (21.49%) were more prevalent in men who practiced anal sex. The type of sex was not associated with oral HPV prevalence. Genital and oral HPV infection were not associated by different sexual practices in the studied population.

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Section: Discussionmentioning

confidence: 99%

Sexual practices and HPV infection in unvaccinated young adults

Pauli

Kops²,

Bessel³

et al. 2022

Sci Rep

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“…As demonstrated by the abovementioned study by Beachler et al [24], anal HPV is also more likely to persist compared to the oral infection. The mucosal immune response and the continuous salivary flow in the oral cavity may be responsible for the faster clearance of HPV infection at this anatomic district [5].…”

Section: Discussionmentioning

confidence: 99%

“…The epidemiology of these two infections, separately, has been largely investigated, evidencing the role of sexual exposure in the acquisition and transmission dynamics, particularly in groups with high frequency of sexual contacts, partners, and practices, such as men who have sex with men (MSM) [2,4]. They in fact harbor the highest prevalence of anal and oral infection [3,5]. Unfortunately, little is known about the correlation between these two infections in MSM.…”

Section: Introductionmentioning

confidence: 99%

Concurrent and Concordant Anal and Oral Human PapillomaVirus Infections Are Not Associated with Sexual Behavior in At-Risk Males

et al. 2021

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Men who have sex with men (MSM) harbor the highest prevalence of anal and oral Human Papillomavirus (HPV) infection, particularly if HIV-infected. We investigated anal and oral HPV infections in HIV-infected and HIV-uninfected MSM, to assess concurrent (HPV detected at both sites, irrespective of the genotypes), and concordant infections (same genotype[s] detected at both sites). Matched anal and oral samples from 161 MSM (85 HIV-infected, and 76 HIV-uninfected) were tested with the Linear Array. Determinants of concurrent and concordant infections were evaluated using logistic regression. Anal infections were 4 to 7 times more frequent than oral infections in both study groups (p < 0.0001). Concurrent infections were not significantly different in HIV-infected (25.9%) and HIV-uninfected MSM (17.1%), p = 0.18. A concordant infection was found in 15 MSM (9.3%). Concordance was for one genotype in 14 individuals and for four genotypes in the remaining subject. In the overall population, only age was independently associated with a concurrent infection (AOR = 3.10, 95% CI: 1.34–7.19 for >39 vs. ≤39 years). None of the parameters of sexual behavior showed independent association with concordant infections. Among MSM, concordant anal and oral HPV infections do not seem to be explained by sexual behavior, but might derive from sequential acquisition by autoinoculation.

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“…10 An oral HPV infection in the MSM population is generally less frequent than an anal one, however, a large heterogeneity in prevalence data exists among individual studies globally. 11 A recently published meta-analytical study by Farahmand et al estimates an overall prevalence of oral HPV infection of 17.3%, (range from 3.8% to 81.9%), and a prevalence of anal HPV infection of 78.4% (range from 29.3% to 98.9%). 11 Such clear between-study heterogeneity results from both technical factors, such as the method of HPV detection, and sociodemographic factors.…”

Section: Introductionmentioning

confidence: 99%

“…11 Such clear between-study heterogeneity results from both technical factors, such as the method of HPV detection, and sociodemographic factors. 11,12…”

Section: Introductionmentioning

confidence: 99%

Prevalence of oral and anal human papillomavirus infection in Czech predominantly HIV-positive men having sex with men - data from a previously unreported population

Němcová¹,

Riegert

Černá³

et al. 2022

Int J STD AIDS

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Background: HIV-positive men who have sex with men (MSM) are more likely to experience human papillomavirus (HPV) infection. The persistent HPV infection is the major factor in the development of anal and oropharyngeal neoplasms. Data on the prevalence of anal and oral HPV in MSM are almost absent from the countries of Central and Eastern Europe. We conducted a cross-sectional study focused on the prevalence of oral and anal HPV infections and the relationship between current anal and oral HPV intrapersonal infection in a Czech population of predominantly HIV-positive MSM. Methods: Oral gargle and anal swab samples from 205 predominantly HIV-positive MSM from the Czech Republic were analysed for HPV infection using PCR. Selected sociodemographic and clinical data were correlated with HPV detection using generalized linear models and multivariate analysis. Results: HPV infection was detected in 183 (96.8%) anal and 48 (23.6%) oral samples. The most common type of HR-HPV was HPV16 in both anal (25.4%) and oral (2.5%) samples. Multiple anal HPV infections and the presence of vaccine-targeted HR-HPV types were significantly correlated with abnormal anal cytology and HIV status. Conclusion: The prevalence of anal HPV infection in Czech predominantly HIV-positive MSM ranks among the highest reported, while oral HPV prevalence is consistent with MSM populations. Minimal overlap of oral and anal HPV types within a patient was observed.

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Prevalence and genotype distribution of human papillomavirus infection in different anatomical sites among men who have sex with men: A systematic review and meta‐analysis

Cited by 24 publications

References 172 publications

Sexual practices and HPV infection in unvaccinated young adults

Sexual practices and HPV infection in unvaccinated young adults

Concurrent and Concordant Anal and Oral Human PapillomaVirus Infections Are Not Associated with Sexual Behavior in At-Risk Males

Prevalence of oral and anal human papillomavirus infection in Czech predominantly HIV-positive men having sex with men - data from a previously unreported population

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