Prevalence and genotype distribution of human papillomavirus infection in Huzhou City, eastern China, 2018–2019

Zhu, Yong; Qian, Fuchu; Zou, Weihua; Wu, Xingwang; Liu, Chunlin; Shen, Guosong; Lai, Songjia; Yang, Sheng Huei

doi:10.1093/trstmh/traa077

Cited by 18 publications

(15 citation statements)

References 51 publications

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“…That China is vast in territory and huge in population, coupled with unbalanced development, and insufficient awareness of prevention and screening in earlier years and nonstandard cervical cancer screening in certain underdeveloped areas resulted in the regional differences in the epidemiology of HPV and cervical cancer. The overall infection rate of hrHPV in different regions of China was 8.8%-25.7% in recent years [4][5][6][19][20][21][22][23][24][25]. Our study showed that the overall infection rate of hrHPV was 20.3%, which was similar to most reviews or researches on the nationwide prevalence of hrHPV infection in China [4][5][6].…”

Section: Discussionsupporting

confidence: 83%

Extensive HPV Genotyping Reveals High Association between Multiple Infections and Cervical Lesions in Chinese Women

Zhong

et al. 2022

Disease Markers

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Objective. The relationship between human papillomavirus (HPV) and cervical lesions has been extensively elucidated, but infection with multiple genotypes is less investigated due to methodology limitations. In the current study, with a method of genotyping 21 HPVs in a routine cervical screening population, we aimed to investigate the prevalence and diversity of HPV infections in Chinese women and further evaluate the impact of multiple infections of HPV on cervical lesion progression. Methods. Totally, 73,596 patients who underwent 21-genotype HPV testing from January 2018 to April 2019 were retrieved from the database of the Department of Pathology, Obstetrics and Gynecology Hospital of Fudan University. HPV testing was performed by real-time PCR assay, including 13 high-risk HPVs (hrHPV), 5 potential hrHPVs, and 3 low-risk HPVs. Results. Of the 17,079 (infection rate, 23.2%) hrHPV- or potential hrHPV- (hr/phrHPV-) positive cases, 26.3% had multiple infections. Women younger than 25 and older than 65 were more prone to multiple infections. Of the hr/phrHPV-positive cases involving cervical intraepithelial neoplasia (CIN) 2 or worse (CIN2+), HPV73, 53, and 66 (=59) were the top three genotypes most likely to be included in multiple infections, while HPV16, 18, and 58 were the 3 least. Patients with single infection of HPV16 had higher incidences of CIN2+ than those with multiple-infection pattern ( P < 0.001 ), indicating that mixing with other genotypes alleviated pathogenicity. The infection of HPV52, 53, 56, 51, 39, 66, 59, 68, and 35 showed an opposite pattern, indicating that they were less likely to be pathogens individually. All other types showed no significant differences, indicating the capability of pathogenesis independently. HPV26 showed a higher OR for CIN2+ than most traditional hrHPV genotypes. The vial load and the percentage of HPV16 showed positive correlation with the severity of cervical lesions. Conclusion. Extensive genotyping identified 3 most frequent genotypes, HPV16, 52, and 58, in CIN2+ of Chinese population. HPV16 mixing with other genotypes alleviated its pathogenicity. The vial load and the percentage of HPV16 were positively correlated with the severity of cervical lesions. HPV26 may be considered as a hrHPV, which needs to be evaluated and confirmed by more cases.

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Section: Discussionsupporting

confidence: 83%

Extensive HPV Genotyping Reveals High Association between Multiple Infections and Cervical Lesions in Chinese Women

Zhong

et al. 2022

Disease Markers

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“…In this present survey, the overall infection rate of high‐risk HPV was 14.26% in Chongqing in China, which was higher than that in Huzhou (13.3%), 9 and lower than in Beijing (21.06%), 14 Guangdong Province (15.66%) 15 …”

Section: Discussionmentioning

confidence: 44%

“…The prevalence rate of HPV infection changes in different countries, 6–8 but also varies in different regions of China 9,10 . It is essential for the prevention and treatment of local cervical cancer to investigate the distribution of HPV genotypes in regions areas (Figure S1).…”

Section: Introductionmentioning

confidence: 99%

Prevalence and genotype distribution of high‐risk human papillomavirus infection among women with cervical cytological abnormalities in Chongqing, China, 2014–2020

Luo

Lang

Han

et al. 2021

Diagnostic Cytopathology

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BackgroundPersistent infection with high‐risk human papillomavirus (HR‐HPV) is the main leading cause of cervical precancerous lesions and cervical cancer. This study aims to explore the epidemiological characteristics of HR‐HPV genotypes and their correlation with the ThinPrep cytological test (TCT) results among women in Chongqing, in China.MethodsIn this retrospective study, cervical exfoliations of 14,548 women who visited Chongqing university cancer hospital were collected for detecting HR‐HPV genotypes and TCT.ResultsOverall, the rate of HR‐HPV infection was 14.26%. The three most common HR‐HPV genotypes are HPV52 (4.39%), HPV58 (2.21%), and HPV16 (1.94%). In this study, the positive rate of cervical TCT was 4.54%. Atypical squamous cells of undetermined significance (ASC‐US), atypical squamous cells that could not exclude high‐grade squamous intraepithelial lesion (ASU‐H), low‐grade squamous intraepithelial lesions (LSIL), high‐grade squamous intraepithelial lesions (HSIL), and atypical glandular cells of undetermined significance (AGC) were 2.99%, 0.20%, 0.92%, 0.29%, and 0.14%, respectively. Among the several types of cytological lesions, the HR‐HPV infection rates of ASC‐US, ASC‐H, LSIL, HSIL, and (AGC) were 24.82%, 41.38%, 64.18%, 95.24%, and 23.81%, respectively.ConclusionsHPV52, HPV 58, and HPV16 are the most common infection subtypes in Chongqing. When implementing HPV vaccine programs in Chongqing, HPV58 and HPV52 should be attached importance as HPV16 and HPV18.

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“…In addition, HPV infection rates differ across regions in China [ 6 – 8 ] Here, we analyzed the HPV prevalence trends from 2016 to May 2021 and found that the overall infection rate was 18.10% (Table 1 ). This is higher than reported in Yunnan (12.9%) [ 6 ], Shanghai (17.92%) [ 8 ], Xinjiang (14.02%) [ 9 ], and Huzhou (15.5%) [ 10 ], and lower than reported in Guangzhou (26.0%) [ 7 ], Sichuan (23.84%) [ 11 ], and Chongqing (19.9%) [ 12 ]. In addition to cultural background and living habits, ethnicity may be an important contributing factor to HPV prevalence in different regions.…”

Section: Discussionmentioning

confidence: 57%

The prevalence and genotype distribution of human papillomavirus among women in Guangxi, southern China

Liu-ting

Qin

et al. 2022

Infect Agents Cancer

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Background Human papillomavirus is a primary cause of cervical cancer and genital warts. HPV vaccine can prevent high-grade cervical lesions as well as cervical cancer. The aim of this study was to analyze the prevalence and genotype distribution of human papillomavirus among women in Guangxi before and after the HPV vaccine was approved for use in China. Methods From January 2016 to May 2021, 41,140 women were tested for HPV infection. HPV genotyping included 15 high-risk HPV (HR-HPV) and 6 low-risk HPV (LR-HPV) genotypes. Total prevalence, annual trend, and specific age group prevalence and genotype distribution were analyzed. Results The overall HPV infection rate was 18.10% among Guangxi women self-referred to clinic for gynecologic problems in southern China. During 2016–2018, the prevalence of HPV infection showed an upward trend, from 18.21% in 2016 to 21.99% in 2018, and later it showed a downward trend, from 18.35% in 2019 to 12.26% in May 2021. Pure HR-HPV genotypes (14.36%) were found in more infections than pure LR-HPV genotypes (2.77%) and mixed genotypes (0.97%). Two peaks of HPV infection were found in the ≤ 25 years (22.94%) and 56–65 years (21.25%) groups. The six most prevalent HR-HPV genotypes were HPV 52 (4.06%), 16 (2.70%), 58 (2.24%), 51 (1.87%), 39 (1.52%), and 53 (1.52%). The three most prevalent LR-HPV genotypes were HPV 6 (1.31%), CP8304 (1.01%), and 11 (0.82%). Infection with a single HR-HPV genotype was the most common type of infection, with an overall infection rate of 12.30%. Infection with two HPV genotypes was the most common multiple HR-HPV infection type, with an infection rate of 2.35%. Conclusions The cervical HPV infection rate of women in Guangxi is very high, and there is significant age specificity. There is a need to increase HPV vaccination of young people and the screening of middle-aged and elderly people.

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Prevalence and genotype distribution of human papillomavirus infection in Huzhou City, eastern China, 2018–2019

Cited by 18 publications

References 51 publications

Extensive HPV Genotyping Reveals High Association between Multiple Infections and Cervical Lesions in Chinese Women

Extensive HPV Genotyping Reveals High Association between Multiple Infections and Cervical Lesions in Chinese Women

Prevalence and genotype distribution of high‐risk human papillomavirus infection among women with cervical cytological abnormalities in Chongqing, China, 2014–2020

The prevalence and genotype distribution of human papillomavirus among women in Guangxi, southern China

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