Prevalence and Genetic Mechanisms of Antimicrobial Resistance in Staphylococcus Species: A Multicentre Report of the Indian Council of Medical Research Antimicrobial Resistance Surveillance Network

Abstract

There were localised differences in the prevalence of resistance between the centres. The efficacy of the anti-MRSA antimicrobials was very high; however, almost all these antimicrobials showed evidence of creeping MIC.

Microbiological profile and antibiotic susceptibility pattern of Gram-positive isolates at a tertiary care hospital

“…The ICMR-AMRSN study reported S. aureus to be the most frequently isolated organism in SSTI patients (73.7%). [823] Similarly, our study also showed similar results with S. aureus isolates to be 61.2% in SSTI patients. Further, we also report a high prevalence of S. aureus (35.1%) in BSI patients.…”

“…[20] In India too, Gram-positive infections, particularly MRSA, have been reported to increase exponentially from 29% in 2009 to 47% in 2014. [21] The overall MRSA prevalence in our study was 29.7%, which was lower than the recently reported prevalence of 37.3% by ICMR-AMRSN[8] and 40% as reported by INSAR study. [22] Furthermore, the prevalence varies among different centers across India ranging from 20.2% in Gujarat to 80.4% in Odisha.…”

“…Moreover, according to national guidelines on antimicrobial use, patients infected with MRSA have a high mortality rate[7] which could be due to various factors such as late detection, manifestation of the underlying susceptibility to infections, and past antibiotic overuse. A recent multicentric study has reported the overall MRSA prevalence to be 37.3%;[8] however, other studies have reported the prevalence to range from 20.2% to 80.4% depending on the geographical region. [9101112]…”

Antibiotic Susceptibility Pattern of Methicillin Sensitive and Resistant Staphylococcus aureus from Clinical Isolates in a Tertiary Care Hospital at Mathura, Western Uttar Pradesh

“…Data on the prevalence of MRSA is not uniform. Literature has documented a significant variation in the prevalence rate from different parts of India and between countries [1][2][3][4][5][6][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28] . Studies from India report MRSA prevalence ranging from 6.9% to 87% 9 .…”

“…In the early 1960s, Methicillin Resistant S.aureus (MRSA) emerged as a potential pathogen causing nosocomial colonization, several outbreaks and difficult-to-treat infections like bacteremia, infective endocarditis, osteoarticular and pleuropulmonary infections. They also causes device related infections like central line associated blood stream infections, ventilator associated pneumonia and catheter associated urinary tract infections [1][2][3][4][5] . It always remains a challenge for physicians to treat and control MRSA infections.…”