Prevalence and genetic diversity of Shibuyunji virus, a novel tick-borne phlebovirus identified in Zambia

Simulundu, Edgar; Mbambara, Saidon; Chambaro, Herman M.; Sichibalo, Karen; Kajihara, Masahiro; Nalubamba, King S.; Sawa, Hirofumi; Takada, Ayato; Changula, Katendi; Chitanga, Simbarashe

doi:10.1007/s00705-020-04924-9

Cited by 3 publications

(2 citation statements)

References 23 publications

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“…On the pathogen discovery front, some strides have been made in that a number of novel arboviruses have been detected in the country. Among them include the tick-borne phlebovirus, Shibuyunji virus, which was detected from Rhipicephalus ticks in Shibuyunji and Namwala district [92,93]. Additionally, Harima and colleagues (2021), characterised the Mpulungu flavivirus, a novel tick-borne flavivirus isolated from a Rhipicephalus muhsamae tick with a typical vertebrate genome signature, suggesting its potential to infect vertebrate hosts [94].…”

Section: Pathogen Discoverymentioning

confidence: 99%

Current knowledge of vector-borne zoonotic pathogens in Zambia: A clarion call to scaling-up “One Health” research in the wake of emerging and re-emerging infectious diseases

et al. 2022

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Background Although vector-borne zoonotic diseases are a major public health threat globally, they are usually neglected, especially among resource-constrained countries, including those in sub-Saharan Africa. This scoping review examined the current knowledge and identified research gaps of vector-borne zoonotic pathogens in Zambia. Methods and findings Major scientific databases (Web of Science, PubMed, Scopus, Google Scholar, CABI, Scientific Information Database (SID)) were searched for articles describing vector-borne (mosquitoes, ticks, fleas and tsetse flies) zoonotic pathogens in Zambia. Several mosquito-borne arboviruses have been reported including Yellow fever, Ntaya, Mayaro, Dengue, Zika, West Nile, Chikungunya, Sindbis, and Rift Valley fever viruses. Flea-borne zoonotic pathogens reported include Yersinia pestis and Rickettsia felis. Trypanosoma sp. was the only tsetse fly-borne pathogen identified. Further, tick-borne zoonotic pathogens reported included Crimean-Congo Haemorrhagic fever virus, Rickettsia sp., Anaplasma sp., Ehrlichia sp., Borrelia sp., and Coxiella burnetii. Conclusions This study revealed the presence of many vector-borne zoonotic pathogens circulating in vectors and animals in Zambia. Though reports of human clinical cases were limited, several serological studies provided considerable evidence of zoonotic transmission of vector-borne pathogens in humans. However, the disease burden in humans attributable to vector-borne zoonotic infections could not be ascertained from the available reports and this precludes the formulation of national policies that could help in the control and mitigation of the impact of these diseases in Zambia. Therefore, there is an urgent need to scale-up “One Health” research in emerging and re-emerging infectious diseases to enable the country to prepare for future epidemics, including pandemics.

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Section: Pathogen Discoverymentioning

confidence: 99%

Current knowledge of vector-borne zoonotic pathogens in Zambia: A clarion call to scaling-up “One Health” research in the wake of emerging and re-emerging infectious diseases

et al. 2022

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“…Ticks, as the primary arthropod vectors of pathogen transmission, can transmit a wide range of arboviruses. It has been shown that a number of arboviruses have a significant impact on public health and can cause a range of symptoms in humans or animals, from mild to severe, and even death, for instance, in the last two decades, severe fever with thrombocytopenia syndrome virus and Alongshan virus in China [1,2], Heartland virus and Bourbon virus in the United States [3,4], Hunter island group virus in Australia [5], Yamaguchi virus, Muko virus and Tarumizu tick virus in Japan [6][7][8], Shibuyunji virus in Zambia [9], Dugbe virus in Ghana [10]. In recent years, with increased attention and the development of next-generation sequencing technology, several novel arboviruses have been identified.…”

Section: Introductionmentioning

confidence: 99%

Molecular evidence for potential transovarial transmission of Dabieshan tick virus in Haemaphysalis longicornis from Shandong Province, China

Wang,

Tang,

Pang

et al. 2023

PLoS ONE

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Dabieshan tick virus (DBTV) is a newly identified arbovirus, first detected in Haemaphysalis longicornis collected from Hubei Province in 2015. It has been confirmed that DBTV is widely distributed in Shandong Province, China. However, its entomological and epidemiological features remain to be further explored, particularly the feasibility of transovarial transmission. Our research tries to explain the possibility of transovarial transmission of DBTV from engorged female ticks to their offspring. All engorged female adult ticks were sampled from domestic sheep and allowed to lay eggs and hatch in appropriate laboratory conditions. All engorged ticks, larvae and unhatched eggs were classified into pools for nucleic acid extraction and DBTV RNA detection. According to the results of qRT-PCR, the positive rate of DBTV was 6.25% (8/128) in engorged female ticks, 3.57% (1/28) in eggs and 5% (3/60) in larvae pools, respectively. Phylogenetic analysis indicated that DBTV isolates from larvae were similar to those from maternal ticks with more than 99.5% homology, and DBTV was relatively conservative in evolution. Our findings are the first to provide molecular evidence of potential transovarial transmission of DBTV among H. longicornis. Nonetheless, the transovarial transmission of DBTV in frequency and proportion occurring in nature deserves further investigation.

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Phlebovirus diversity in ticks from livestock in arid ecologies in Kenya

Ogola

Kopp

Bastos

et al. 2023

Ticks and Tick-borne Diseases

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Prevalence and genetic diversity of Shibuyunji virus, a novel tick-borne phlebovirus identified in Zambia

Cited by 3 publications

References 23 publications

Current knowledge of vector-borne zoonotic pathogens in Zambia: A clarion call to scaling-up “One Health” research in the wake of emerging and re-emerging infectious diseases

Current knowledge of vector-borne zoonotic pathogens in Zambia: A clarion call to scaling-up “One Health” research in the wake of emerging and re-emerging infectious diseases

Molecular evidence for potential transovarial transmission of Dabieshan tick virus in Haemaphysalis longicornis from Shandong Province, China

Phlebovirus diversity in ticks from livestock in arid ecologies in Kenya

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