Prevalence and family risk of ulcerative colitis and Crohn's disease: an epidemiological study among Europeans and south Asians in Leicestershire.

Probert, Chris; Venkataraman, Jayanthi; Hughes, Anita J.; Thompson, John R.; Wicks, A. C. B.; Mayberry, J F

doi:10.1136/gut.34.11.1547

Cited by 200 publications

(109 citation statements)

References 24 publications

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“…Specifically, the PubMed and OMIM databases were queried for genes having a link (1) to inflammation (over-/under-expression in inflamed tissues, and pro-/anti-inflammatory role), (2) to immunity (regulation of immune responses or immune cell proliferation), (3) to the development of a bowel disease (malformation, bowel cancer, and intestinal dysfunction), and (4) to experimental models of intestinal inflammation (genetic mouse model or activation/inhibition of experimental models). The Unigene and SymAtlas databases were also queried for genes showing expression patterns compatible with a role in immune and/or intestinal tissues (tissue-specific expression patterns or marked over-expression in tissues of immune or intestinal origin).…”

Section: Candidate Gene Selectionmentioning

confidence: 99%

Gene-centric association mapping of chromosome 3p implicates MST1 in IBD pathogenesis

Goyette

Lefèbvre

et al. 2008

Mucosal Immunology

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Association mapping and candidate gene studies within IBD linkage regions, as well as genomewide association studies in CD have led to the discovery of multiple risk genes, but these only Corresponding author: John D. Rioux, Montreal Heart Institute, 5000 Belanger Street, Montreal, Quebec, Canada, H1T 1C8, rioux@inflammgen.org. HHS Public Access Author Manuscript Author ManuscriptAuthor ManuscriptAuthor Manuscript explain a fraction of the genetic susceptibility observed in IBD. We have thus been pursuing a region on chromosome 3p21-22 showing linkage to CD and UC using a gene-centric association mapping approach. We identified twelve functional candidate genes by searching for literature cocitations with relevant keywords and for gene expression patterns consistent with immune/ intestinal function. We then performed an association study composed of a screening phase, where tagging SNPs were evaluated in 1020 IBD patients, and an independent replication phase in 745 IBD patients. These analyses identified and replicated significant association to IBD for four SNPs within a 1.2 Mb LD region. We then identified a non-synonymous coding variant (rs3197999, R689C) in the macrophage stimulating 1 (MST1) gene (p-value 3.62×10−6) that accounts for the association signal, and shows association to both CD and UC. MST1 encodes MSP, a protein regulating the innate immune responses to bacterial ligands. R689C is predicted to interfere with MSP binding to its receptor, suggesting a role for this gene in the pathogenesis of IBD.

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Section: Candidate Gene Selectionmentioning

confidence: 99%

Gene-centric association mapping of chromosome 3p implicates MST1 in IBD pathogenesis

Goyette

Lefèbvre

et al. 2008

Mucosal Immunology

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“…In addition, epidemiologic studies have revealed that relatives of a patient with UC or CD have a higher risk of developing either form of IBD. [1][2][3] This suggests that UC and CD share certain genetic susceptibility loci and that the ultimate phenotypic expression of the disease also depends on other factors such as genetic modifier loci and environmental influences.…”

Section: Introductionmentioning

confidence: 99%

The role of the Toll receptor pathway in susceptibility to inflammatory bowel diseases

et al. 2007

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The intestinal flora has long been thought to play a role either in initiating or in exacerbating the inflammatory bowel diseases (IBD). Host defenses, such as those mediated by the Toll-like receptors (TLR), are critical to the host/pathogen interaction and have been implicated in IBD pathophysiology. To explore the association of genetic variation in TLR pathways with susceptibility to IBD, we performed a replication study and pooled analyses of the putative IBD risk alleles in NFKB1 and TLR4, and we performed a haplotype-based screen for association to IBD in the TLR genes and a selection of their adaptor and signaling molecules. Our genotyping of 1539 cases of IBD and pooled analysis of 4805 cases of IBD validates the published association of a TLR4 allele with risk of IBD (odds ratio (OR): 1.30, 95% confidence interval (CI): 1.15-1.48; P ¼ 0.00017) and Crohn's disease (OR: 1.33, 95% CI: 1.16-1.54; P ¼ 0.000035) but not ulcerative colitis. We also describe novel suggestive evidence that TIRAP (OR: 1.16, 95% CI: 1.04-1.30; P ¼ 0.007) has a modest effect on risk of IBD. Our analysis, therefore, offers additional evidence that the TLR4 pathway -in this case, TLR4 and its signaling molecule TIRAP -plays a role in susceptibility to IBD.

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“…Studies of migrants from South Asia to developed countries have proved particularly informative in this regard. In Leicestershire, UK, the standardized prevalence of CD in Europeans was 75.8/10 5 while among South Asians, it was 33.2/10 5 [8]. In the same area, the standardized incidence in South Asians during the 1980s was 2.4/10 5 /year in Hindus, 3.4/10 5 /year in Sikhs, and 5.4/10 5 /year in Muslims, none of these being significantly different from that in Europeans, which was 4.7/10 5 /year [9].…”

Section: The Prevalence Of CD In Indian Immigrants To Developed Countmentioning

confidence: 97%

“…Values shown are percentage of cases with the feature in each group TB tuberculosis, CD Crohn's disease Indian J Gastroenterol (January-February 2015) 34(1): [3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22]appropriate to re-endoscope patients who were treated empirically for intestinal tuberculosis and to establish complete mucosal healing at the end of 6 months. The Task Force was in agreement that this should be done, in view of the possibility that recurrent symptoms would make it difficult to judge whether the patient was in fact having intestinal tuberculosis or CD during the first episode.…”

mentioning

confidence: 99%

Indian Society of Gastroenterology consensus statements on Crohn’s disease in India

Ramakrishna

Makharia

Ahuja

et al. 2015

Indian J Gastroenterol

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In 2012, the Indian Society of Gastroenterology's Task Force on Inflammatory Bowel Diseases undertook an exercise to produce consensus statements on Crohn's disease (CD). This consensus, produced through a modified Delphi process, reflects our current recommendations for the diagnosis and management of CD in India. The consensus statements are intended to serve as a reference point for teaching, clinical practice, and research in India.

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Prevalence and family risk of ulcerative colitis and Crohn's disease: an epidemiological study among Europeans and south Asians in Leicestershire.

Cited by 200 publications

References 24 publications

Gene-centric association mapping of chromosome 3p implicates MST1 in IBD pathogenesis

Gene-centric association mapping of chromosome 3p implicates MST1 in IBD pathogenesis

The role of the Toll receptor pathway in susceptibility to inflammatory bowel diseases

Indian Society of Gastroenterology consensus statements on Crohn’s disease in India

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