Prevalence and factors leading to unemployment in MS (multiple sclerosis) patients undergoing immunomodulatory treatment in Poland

Koziarska, Dorota; Król, Joanna; Nocoń, D; Kubaszewski, Przemysław; Rzepa, Teresa; Nowacki, Przemysław

doi:10.1371/journal.pone.0194117

Cited by 17 publications

(19 citation statements)

References 33 publications

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“…67.4% of these were no longer working due to their disease. This is consistent with previous studies, which identified fatigue as one of the most relevant causes for unemployment in MS [ 10 , 12 ]. Along with this, a significant correlation between a higher EDSS value and a present fatigue could be found.…”

Section: Discussionsupporting

confidence: 93%

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The Effect of Coffee and Caffeine Consumption on Patients with Multiple Sclerosis-Related Fatigue

Herden

Weissert

2020

Nutrients

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Background: Coffee and caffeine are considered to have beneficial effects in patients with multiple sclerosis (MS), an autoimmune disease of the central nervous system (CNS) that can lead to disability and chronic fatigue. Methods: In the present study the preference in terms of coffee and caffeine consumption in patients with MS was assessed. In total the opinions of 124 MS patients were explored with a questionnaire, which was developed to investigate the consumption behavior and associated beneficial and harmful effects of coffee and caffeine concerning symptoms of fatigue. Results: Our study showed that 37.1% of the included patients experience severe symptoms of fatigue. In our cohort, fatigue was not related to age, type of diagnosis or duration of the disease. The effects of coffee did not differ between MS patients with and without fatigue. Very few side effects linked to coffee consumption were reported, and we could demonstrate that coffee consumption had no negative impact on quality of sleep. A positive effect on everyday life was observed particularly among patients with a mid-level expanded disability status scale (EDSS). The strongest effects of coffee consumption were observed regarding a better ability to concentrate while fulfilling tasks, an expanded attention span and a better structured daily routine. Conclusions: Since coffee showed no severe side effects and in the absence of an effective fatigue therapy, coffee consumption might be a therapeutic approach for selected patients with MS-related fatigue.

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Section: Discussionsupporting

confidence: 93%

“…As a result, their ability to work is particularly severely affected [ 5 ]. Fatigue is also one of the main causes of unemployment or early retirement in people with MS [ 9 , 10 , 11 , 12 ]. As therapy, some substances have been tested for their effectiveness.…”

Section: Introductionmentioning

confidence: 99%

The Effect of Coffee and Caffeine Consumption on Patients with Multiple Sclerosis-Related Fatigue

Herden

Weissert

2020

Nutrients

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“…Patients with bout onset MS, better educated, residents of large cities, as well as those who informed the employer about the disease and received support from him, worked longer. The current results are in line with the study by Salter et al and Koziarska et al, in which PPMS and more severe disability were among the factors associated with not working [10,36]. Patients who did not work at the time of the study most often received a disability pension.…”

Section: Discussionsupporting

confidence: 92%

“…The vast majority of them applied for this benefit within one year of the diagnosis of MS. The disability pension was mainly used by the less educated respondents, those with progressive MS variants and more advanced disability, which coincides with the shorter time of their professional activity, and remains consistent with the results of authors from various regions of the world [36,37,38]. In the presented study, more frequent use of disability pension by patients living in the countryside is consistent with the available data for the Polish population, and can be closely related to the shorter time of their occupational activity [14,39].…”

Section: Discussionsupporting

confidence: 88%

New insights into the socio-economic aspects of multiple sclerosis in a cohort of Polish patients

Rzepiński¹,

Zawadka‐Kunikowska

Kucharczuk³

et al. 2020

Ann Agric Environ Med.

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Introduction and objective. The diagnosis of multiple sclerosis (MS) affects the socioeconomic aspects of patients' lives and poses new challenges. The objectives of the study were: 1) to determine selected socioeconomic aspects of MS in Poland in relation to the disease type and patients' place of residence, and 2) to evaluate the profile of patients via the MS Society (MSS) and the occupational consequences of informing an employer about the diagnosis. Materials and method. A retrospective, observational study was undertaken to assess a cohort of 375 Polish MS patients. Socioeconomic data was collected based on the patients' responses to questions on a questionnaire. Clinical data was obtained from available medical records. Results. Patients with relapsing-remitting MS had a significantly longer time of occupational activity, higher economic status, higher level of education, better relationships with life partner, less likely to benefit from disability benefits, and members of MSS, than patients with progressive types of the disease. The patients living in rural areas had a significantly shorter time of occupational activity, more often experienced a decrease in income, received disability pension, and were less educated than urban residents. Patients who informed their employer about an MS diagnosis significantly more often received support from the company, were professionally active for longer, and less likely to experience a decrease in income. Membership of the MSS were dominated by patients with progressive variants of the disease and advanced disability. Conclusions. The disease variant and, to a lesser extent, the place of residence, affected the socioeconomic aspects of MS. It might be advantageous for the patient to disclose information about MS diagnosis to the employer.

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“…Studies have shown that 14% of patients with MS consider fatigue their worst problem and 55% as one of their worst problems (7). It is also one of the main reasons for unemployment and early retirement (8–10). Patients with multiple sclerosis-related fatigue (MSRF) have a significantly increased mental and physical disability and a lower quality of life (11).…”

Section: Introductionmentioning

confidence: 99%

The Impact of Coffee and Caffeine on Multiple Sclerosis Compared to Other Neurodegenerative Diseases

Herden

Weissert

2018

Front. Nutr.

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Background: The literature concerning the effect of coffee and caffeine on Multiple Sclerosis (MS) with focus on fatigue is investigated in this review. Potentially clinically relevant effects were also assessed in studies concerning comparable neurodegenerative diseases, such as Parkinson's disease (PD) and amyotrophic lateral sclerosis (ALS). Since the existing studies obtained very inconclusive results, we systematically reviewed these studies to summarize the evidence on the possible effects of coffee and caffeine on those disease entities. Previous studies suggested that coffee and caffeine intake is associated with a reduced risk of developing MS and other neurological diseases.Methods: The PubMed database was searched using the keywords “coffee” OR “caffeine” in combination with keywords for each of the different diseases. Besides the keyword search, we included studies by reference list search. Studies on the effects of coffee and caffeine on the single neurological diseases were included for this review. A total of 51 articles met our inclusion criteria. The reviewed articles assessed the impact of coffee and caffeine on the susceptibility for neurological diseases, as well as the effect of coffee and caffeine on disease progression and possible symptomatic effects like on performance enhancement.Results: Higher intake of coffee and caffeine was associated with a lower risk of developing PD. In some of the MS studies there, is evidence for a similar effect and experimental studies confirmed the positive impact. Interestingly in MS coffee and caffeine may have a stronger impact on disease course compared to effects on disease susceptibility. In ALS no such beneficial effect could be observed in the clinical and experimental studies.Conclusion: This literature assessment revealed that coffee and especially caffeine could have a preventative role in the development of several neurodegenerative diseases if provided in comparatively high doses. The systematic assessment indicates that coffee and caffeine intake must not be considered as a health risk. Additional clinical studies are needed to fully understand how far coffee and caffeine intake should be considered as a potential therapeutic approach for certain disease entities and conditions.

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Prevalence and factors leading to unemployment in MS (multiple sclerosis) patients undergoing immunomodulatory treatment in Poland

Cited by 17 publications

References 33 publications

The Effect of Coffee and Caffeine Consumption on Patients with Multiple Sclerosis-Related Fatigue

The Effect of Coffee and Caffeine Consumption on Patients with Multiple Sclerosis-Related Fatigue

New insights into the socio-economic aspects of multiple sclerosis in a cohort of Polish patients

The Impact of Coffee and Caffeine on Multiple Sclerosis Compared to Other Neurodegenerative Diseases

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