Prevalence and factors associated with motoric cognitive risk syndrome in community‐dwelling older Chinese: a cross‐sectional study

Motor cognitive risk syndrome (MCR) is a novel pre-dementia syndrome characterized by the combination of subjective cognitive complaints and slow walking speed in older adults without any form of dementia or motor disability [1]. Previous studies have shown that MCR is associated with fall, death, disability and other adverse health outcomes [2]. A fall is a sudden, involuntary, unintentional change in position to the ground or a lower plane. Falls in the elderly are a significant public health issue and are the major cause of injury-related disability-adjusted life years and the third most common cause of accidental injury-related death globally [3,4]. Falls

Section: Methodsmentioning

confidence: 97%

Section: Motoric Cognitive Risk Syndrome Criteriamentioning

confidence: 99%

Prevalence/potential risk factors for motoric cognitive risk and its relationship to falls in elderly Chinese people: a cross‐sectional study

Yuan¹,

Zhao

et al. 2021

“…The frequency of nutrient intake was assessed based on the ingredient categories in the Dietary Guidelines for Chinese Residents (2016 edition) [20], that is, grains and potatoes, miscellaneous beans, soybean products, vegetables, fruits, nuts, edible fungi and algae, livestock and poultry meat, aquatic products, eggs and milk, and dairy products. Other lifestyle factors were coded "yes" if so, including current smoking and current alcohol drinking [21], and oral hygiene of received professional dental cleaning. Social function was assessed by Social Support Rate Scale (SSRS) [22].…”

Section: Demographics Lifestyle Activities and Social Supportmentioning

confidence: 99%

The prevalence and associated factors of motoric cognitive risk syndrome in multiple ethnic middle‐aged to older adults in west China: a cross‐sectional study

Sun

Harris

Hou

et al. 2022

Background and purpose: Motoric cognitive risk (MCR) syndrome characterized by subjective cognitive complaints and slow gait has been proposed and validated as a pre-dementia syndrome. The overall and specific ethnic prevalence of MCR and the associated factors are poorly understood in middle-aged to older community-dwelling residents in west China. Methods:The present study included 6091 samples from the prospective cohort study, West China Health and Aging Trend (WCHAT). Multidimensional factors of demography, lifestyle, social support, anthropometrics and body components, and clinical status were investigated and analyzed by univariate and multivariate logistic regression models. Lasso regression and K-fold cross-validation were conducted to construct the most predictive model with fitted factors. Results:The overall prevalence of MCR was 9.74%, and ethnically the prevalence was 14.25% in Tibetan, 11.03% in Yi, 10.72% in Han, 5.18% in Uighur and 4.55% in Qiang, respectively. In the adjusted models, the positively associated risk factors included diabetes mellitus (odds ratio [OR] = 1.51, p = 0.007), osteoarthritis (OR = 1.50, p = 0.002), depression (OR = 1.36, p = 0.005), poor sleep (OR = 1.21, p = 0.045), comorbidity (OR = 1.49, p = 0.001) and falls in the last 12 months (OR = 1.34, p = 0.031). Of note, every 1-unit increase of value in stroke was associated with an approximate 3-fold higher risk of having MCR, whilst in high-density lipoprotein with a 30% lower risk of MCR,respectively.Conclusions: Profiles of MCR from the aspects of ethnicity and the presenium stage need further exploration. It is a promising strategy to apply MCR as a primary prevention tool to prevent dementia. | 1355 MOTORIC COGNITIVE RISK SYNDROME IN MULTIPLE ETHNICS INTRODUC TI ON An estimated 55 million people are currently living with dementia globally [1], with forecasts reaching 78 million by 2030 and 152 million by 2050, 60%-80% of which can be attributed to Alzheimer's disease (AD) [1-3]. The Alzheimer's Disease International estimated that 75% of individuals with dementia are not diagnosed and 90% of them are in undeveloped and underdeveloped regions and countries [1]. Dementia is a disease with multifactorial etiology and heterogeneous clinical presentation and disease trajectory. Also, dementia has a long preclinical phase from several years to decades before the cognitive alterations indicating mild cognitive impairment (MCI) are detectable [3,4]. Motoric cognitive risk (MCR) syndrome was proposed and validated in 2013 by Verghese and colleagues to identify aging individuals at high risk for dementia during the pre-dementia stage [5,6]. Approximately 10% of older persons are affected by MCR worldwide [7]. This syndrome integrates two specific harbingers of dementia, subjective cognitive complaints (SCC) and slow gait speed (SG), in the absence of mobility disability and dementia [5,6]. MCR was found to be more strongly associated with cognitive decline or dementia than either of these two harbingers alone [3,8]. Cognitive fun...

“…Their data formed the baseline data of this community-based cohort study. Detailed information of this study has been reported elsewhere [19]. The overall goal of the NCSA was to identify the health status of a community-dwelling elderly Chinese population and explore the helpful management and interventions for preventing geriatric diseases.…”

Section: Study Participantsmentioning

confidence: 99%

Association between sleep disturbance with motoric cognitive risk syndrome in Chinese older adults

Zeng

Zhang

Feng

et al. 2021

Self Cite

Background and purpose Sleep disturbance and cognitive impairment are common and related in the elderly population worldwide. The aim of the present study was to explore the association between sleep disturbance and motoric cognitive risk (MCR) syndrome, which is characterized by subjective cognitive complaints and objective slow gait in older individuals without dementia or any mobility disability in the community‐dwelling elderly Chinese population. Methods We recruited 940 participants aged ≥65 years from November 2016 to March 2017 in the Ningbo Community Study on Aging (NCSA). Self‐reported sleep duration and sleep‐quality variables, comprehensive geriatric evaluation, as well as indicators for diagnosing MCR syndrome were evaluated in this cross‐sectional study. Results Multiple logistic regression analysis showed that a 1‐SD increase in night (1.1 h) and 24‐h sleep duration (1.3 h) was associated, respectively, with a 21% (95% confidence interval [CI], 1%–47%; p = 0.04) and 30% (95% CI, 3%–64%; p = 0.03) higher odds of having MCR syndrome. Considering sleep duration as a categorical variable, longer night‐sleep duration (>8.5 h) was associated with MCR syndrome (OR, 2.03; p = 0.02) compared to shorter night‐sleep duration (<8 h). For sleep‐quality factors, increasing frequency of trouble falling asleep, waking early or easily, nightmares, and taking sleep drugs were significantly associated with MCR syndrome after adjusting for potential covariables (all p for trend < 0.05), but not for self‐perceived sleep quality (p for trend = 0.10). Conclusions Long sleep duration, poor sleep quality, and taking sleep drugs were associated with higher odds of having MCR syndrome in the community‐dwelling elderly Chinese population. Further research is needed to explore the underlying mechanisms.