Prevalence and factors associated with depression and anxiety in people living with HTLV-1: A systematic review with meta-analysis and meta-regression

Souza, Lucca S; Lins-Silva, Daniel H.; Dorea-Bandeira, Ingrid; Barouh, Judah L; Tolentino, Arthur; Bandeira, Igor D.

doi:10.1016/j.genhosppsych.2021.08.012

Cited by 6 publications

(3 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…HTLV-1-позитивные пациенты имели самые низкие когнитивные показатели и самый широкий спектр тревожнодепрессивных симптомов [75,76]. Депрессивное состояние у пациентов с HAM/TSP негативно влияет на разные сферы их повседневной жизни, в том числе на работоспособность [77].…”

Section: психические нарушенияunclassified

Заболевания, Ассоциированные С Т-Лимфотропным Вирусом Типа 1 Человека (HTLV-1)

Радыгина,

Мочалова

2024

Microbiology Independent Research Journal (MIR Journal)

View full text Add to dashboard Cite

ВВЕДЕНИЕ: Т-лимфотропный вирус типа 1 человека (HTLV-1) относится к семейству Retroviridae (род Deltaretrovirus) и напрямую участвует в канцерогенезе. Геном HTLV-1 представлен плюс-цепью РНК, которая транскрибируется в провирусную ДНК, а затем встраивается в геном клетки хозяина. После интеграции HTLV-1 присутствует в клетке в форме провируса. Как и для вируса иммунодефицита человека, основными мишенями HTLV-1 служат CD4+ T-лифоциты. Вирус передается через биологические жидкости организма: сперму, кровь и грудное молоко, – то есть половым путем, при гемотрансфузии и грудном вскармливании. Что касается эпидемиологии HTLV-1, то она до сих пор остается загадкой: кластеры с высокой эндемичностью часто расположены вблизи районов, где вирус практически отсутствует. ЦЕЛЬ: Проанализировать клиническую картину, диагностику и лечение заболеваний, вызванных HTLV-1. МЕТОДЫ: Проведен поиск литературы в базах PubMed, elibrary.ru и cyberleninka.ru по ключевым словам: «HTLV-1»+«diseases», «HTLV-1»+«diagnosis», «HTLV-1»+«epidemiology», «HTLV-1»+«treatment», «HTLV-1»+«Russia»; «HTLV-1»+«болезни», «HTLV-1»+«диагностика», «HTLV-1»+«эпидемиология», «HTLV-1»+«лечение», «HTLV-1»+«Россия». Основной поиск проведен за 2020–2024 гг. РЕЗУЛЬТАТЫ: С HTLV-1 связаны такие заболевания, как Т-клеточный лейкоз/лимфома и миелопатия/тропический спастический парапарез. При HTLV-1-инфекции регистрируют патологии большинства систем органов. В связи с тем, что ассоциированные с HTLV-1 заболевания чаще всего протекают бессимптомно, этиологическую диагностику проводят уже на стадии развития патологии или при скрининге крови доноров на патогены. ЗАКЛЮЧЕНИЕ: В обзоре рассмотрены вопросы клинических проявлений и течения заболеваний, вызванных HTLV-1, их диагностики и лечения. Несколько настораживает отсутствие серьезных популяционных исследований по распространенности этого вируса – фактически, диагностика на HTLV-1 предусмотрена только у доноров и у беременных. До сих пор этот вирус считается эндемичным для ряда территорий (Африка, Австралия, Ближний Восток, Япония и др.) и некоторых коренных народов, но, учитывая беспрецедентные миграционные потоки и международные связи в современном мире, мы считаем важным привлечь к нему внимание как эпидемиологов, так и клиницистов.

show abstract

Section: психические нарушенияunclassified

Заболевания, Ассоциированные С Т-Лимфотропным Вирусом Типа 1 Человека (HTLV-1)

Радыгина,

Мочалова

2024

Microbiology Independent Research Journal (MIR Journal)

View full text Add to dashboard Cite

show abstract

“…HTLV-1 infection is commonly associated with marginalized groups such as sex workers, immigrants, and First Nations communities ( 5 ). Furthermore, routes of transmission are varied, being through contaminated blood products, vertical transmission via prolonged breastfeeding, and condomless sexual intercourse ( 6 ).…”

Section: Introductionmentioning

confidence: 99%

How do socioeconomic determinants of health affect the likelihood of living with HTLV-1 globally? A systematic review with meta-analysis

Ramesh,

Cockbain,

Taylor

et al. 2024

Front. Public Health

View full text Add to dashboard Cite

IntroductionHuman T Lymphotropic Virus type 1 (HTLV-1) is a neglected retrovirus associated with many clinical disorders, most notably Adult T-cell Leukemia/Lymphoma and HTLV-1-Associated Myelopathy (HAM). Found in endemic clusters across the world, high prevalence has been reported in minoritized groups who suffer from health inequities. This study investigates the association between HTLV-1 prevalence and the following socioeconomic determinants of health: education, income, and employment, which are markers of health inequity.MethodsA systematic review was conducted by searching the following databases: Ovid/Medline, Embase, Global Health Database, Web of Science, LILACS and SciELO. Primary studies in English, Spanish and Portuguese mentioning HTLV-1 and one of education, income and/or employment were included. A random-effects meta-analysis was performed, and odds ratios (OR) were calculated to determine the association between these socioeconomic determinants of health and HTLV-1 prevalence.Results42 studies were included. The likelihood of having HTLV-1 was higher in individuals with less than completed primary education compared to those who completed primary education (OR 1.86 [95% CI 1.34–2.57]; p < 0.01). This may be because individuals with low education have reduced access to and understanding of health information, thus increasing the prevalence of risk factors associated with HTLV-1 infection. No other determinants were found to be statistically significant.ConclusionFewer years of schooling are associated with increased likelihood of contracting HTLV-1. Therefore, health promotion materials and public health policies regarding HTLV-1 must consider those with lower educational levels to effectively reduce disease transmission.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?RecordID=335004, identifier (CRD42022335004).

show abstract

“…[ 7 , 8 ] However, there is an inconsistency between the findings of the studies that evaluated psychological abnormalities among HTLV-1 patients. While some studies showed that the prevalence of psychiatric disorders was significantly higher among HTLV-1 asymptomatic carriers compared to the general population,[ 10 - 12 ] some other studies reported no significant difference in the prevalence of depression between HTLV-1 and healthy subjects. [ 13 , 14 ]…”

Section: Introductionmentioning

confidence: 99%

Prevalence of sexual dysfunction in HTLV-1 patients without spastic paraparesis and the association with psychiatric symptoms

Kamrani

Rad

Zemorshidi

et al. 2023

Indian Journal of Psychiatry

View full text Add to dashboard Cite

Introduction: The findings of previous studies are inconclusive in terms of psychological abnormalities and sexual function in asymptomatic human lymphotropic virus type 1 (HTLV-1) carriers. Aim: This study aimed to evaluate the prevalence of sexual dysfunction and its relationship with psychological abnormalities in asymptomatic HTLV-1 carriers. Materials and Methods: This cross-sectional study was conducted on asymptomatic HTLV-1 patients who were referred to the Neurology Clinic of a tertiary hospital in Mashhad, Iran. Patients with spastic paraparesis, leukemia, and uveitis, and those with an expanded disability status scale (EDSS) score higher than 2 were excluded. Sexual function in male and female subjects was evaluated using the brief male sexual function inventory (BMSFI) and female sexual dysfunction index (FSFI) questionnaires, respectively. The severity of psychological symptoms was evaluated in all patients using the symptom checklist-90-revised (SCL-90-R) questionnaire. Results: A total of 117 patients (61 males and 56 females) with a mean age of 35.3 ± 6.3 years were evaluated. Overall, 50.9% of males had a high and 39.3% of females had a good sexual function. Both male and female patients with poor sexual function were older and had more children compared to those with good sexual function ( P < 0.05). There was no significant difference in the distribution pattern of SCL-90 domains between patients with high and low to moderate sexual function among male patients ( P > 0.05). Depression, hostility, interpersonal sensitivity, paranoid ideation, and psychological abnormality were significantly more prevalent in female patients with poor sexual function compared to those with good sexual function ( P < 0.05). Conclusion: The prevalence of psychological abnormalities was high in female with sexual dysfunction and these disorders might have a negative effect on various dimensions of sexual function.

show abstract

Prevalence and factors associated with depression and anxiety in people living with HTLV-1: A systematic review with meta-analysis and meta-regression

Cited by 6 publications

References 43 publications

Заболевания, Ассоциированные С Т-Лимфотропным Вирусом Типа 1 Человека (HTLV-1)

Заболевания, Ассоциированные С Т-Лимфотропным Вирусом Типа 1 Человека (HTLV-1)

How do socioeconomic determinants of health affect the likelihood of living with HTLV-1 globally? A systematic review with meta-analysis

Prevalence of sexual dysfunction in HTLV-1 patients without spastic paraparesis and the association with psychiatric symptoms

Contact Info

Product

Resources

About