Prevalence and factors associated with poor sleep quality in inflammatory bowel disease outpatients

Calvo, E.; Gil, Miguel Durá; Jiménez, Benito Velayos; Fernández-Salazar, Luis

doi:10.17235/reed.2020.7202/2020

Cited by 9 publications

(11 citation statements)

References 18 publications

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“…Other contributors to poor sleep in inactive IBD may include differences in levels of physical activity or age, both known to be associated with poor sleep 39 . Mental health conditions such as anxiety and depression are prevalent in IBD and have been demonstrated to influence sleep 10–17 . It has also been hypothesized that this poor sleep may represent “learned insomnia” from previous active IBD and may respond well to targeted insomnia treatment such as specific cognitive behavioral therapy, with a recent feasibility study showing encouraging results 40 …”

Section: Discussionmentioning

confidence: 99%

“… 39 Mental health conditions such as anxiety and depression are prevalent in IBD and have been demonstrated to influence sleep. 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 It has also been hypothesized that this poor sleep may represent “learned insomnia” from previous active IBD and may respond well to targeted insomnia treatment such as specific cognitive behavioral therapy, with a recent feasibility study showing encouraging results. 40 …”

Section: Discussionmentioning

confidence: 99%

“…One may see this as being related to IBD symptoms and in particular nocturnal symptoms; however, sleep disturbance may also be an indicator of subclinical inflammation, with studies suggesting that endoscopic activity and histological activity in the setting of clinical remission had high rates of poor sleep. 8 , 9 Sleep quality in IBD has also been associated with psychosocial factors such as depression 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 and reduced physical activity. 18 , 19 …”

Section: Introductionmentioning

confidence: 99%

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Systematic review and meta‐analysis of sleep quality in inactive inflammatory bowel disease

et al. 2022

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Poor sleep in people with inflammatory bowel disease (IBD) has been demonstrated to be prevalent and has been associated with disease activity. This meta‐analysis aimed to assess the prevalence of poor sleep in inactive IBD and in controls by considering cohort and cross‐sectional studies. Electronic databases were searched for publications from inception to 1 November 2021. Poor sleep and IBD activity were defined according to self‐reported subjective sleep measures. A random effects model was used to determine the standardized mean difference between poor sleep in inactive IBD and healthy controls. Publication bias was assessed by funnel plot and Egger's test. Five hundred and nineteen studies were screened with 9 studies included in the meta‐analysis incorporating a total of 729 people with IBD and 508 controls. A random effects model showed a standardized mean difference with poor sleep being more frequent in those with inactive IBD than controls with moderate effect size (Hedge's g 0.41, CI [0.22–0.59]) and no significant heterogeneity. There was no publication bias evident. Poor sleep is more common in individuals with inactive IBD than healthy controls. Further studies should consider potential mechanisms to explain this result, including the role of subclinical inflammation and psychosocial factors that may influence sleep quality in people with IBD.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Systematic review and meta‐analysis of sleep quality in inactive inflammatory bowel disease

et al. 2022

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“…Endoscopically or histologically active IBD in the absence of any IBD symptoms may be sufficient to disrupt sleep 14,15 . There have been several association studies of sleep and IBD with comorbid depression 16–23 frequently associated with poor sleep, and low physical activity associated with poor sleep 19,24 …”

Section: Introductionmentioning

confidence: 99%

Examining the influence of inflammatory bowel disease medications on sleep quality

et al. 2023

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Background and Aim: Inflammatory bowel disease (IBD) can disrupt sleep, leading to poor sleep quality. This may in part be due to the symptoms of IBD and the influence of pro-inflammatory cytokines on sleep. This study aimed to investigate the potential influence of IBD medications on sleep quality. Methods: An online survey of adults with IBD was conducted, which included measures of sleep quality, IBD activity, anxiety, depression, and physical activity. Logistic regression was used to investigate possible associations between IBD medications (corticosteroids, immunomodulators, biologics, aminosalicyate) and outcome of poor sleep. A generalized linear model was built for outcome of sleep quality score. Results: There were 544 participants included in the final analysis, median age of 42, and 61% with Crohn's disease. Increased odds of poor sleep were seen in those taking opioids, medications for anxiety or depression, corticosteroids, vitamin D, methotrexate, and infliximab. A multivariate model was built incorporating demographic and IBD variables with opioids present in the final model and associated with increased odds of poor sleep. This was in addition to medications for sleep, depression, anxiety, IBD activity, and body weight. In a multivariate generalized linear model, opioids and methotrexate were associated with worse sleep quality scores. Conclusions: Opioids were associated with increased odds of poor sleep independent of other factors. This provides further support for avoiding these medications in people with IBD. Infliximab was associated with increased body weight and consequently increased odds of poor sleep.

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“…As most of these patients require immunosuppressive drugs and biologics, they require continuous disease assessment and medical attention. The negative impact of the disease on patient-reported outcomes (PRO) such as quality of life (QoL), disability, work productivity, sleep disorders, and anxiety have been clearly demonstrated in patients with IBD (4,5).…”

Section: Introductionmentioning

confidence: 99%

Health-related quality of life decline in clinically stable inflammatory bowel disease patients during the COVID-19 outbreak

Guise¹,

Ayala²,

Ruiz³

et al. 2022

Rev Esp Enferm Dig

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Prevalence and factors associated with poor sleep quality in inflammatory bowel disease outpatients

Cited by 9 publications

References 18 publications

Systematic review and meta‐analysis of sleep quality in inactive inflammatory bowel disease

Systematic review and meta‐analysis of sleep quality in inactive inflammatory bowel disease

Examining the influence of inflammatory bowel disease medications on sleep quality

Health-related quality of life decline in clinically stable inflammatory bowel disease patients during the COVID-19 outbreak

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