Prevalence and Factors Associated with Subclinical Hypothyroidism in Major Depressive Disorder Patients with Dyslipidemia

Abstract

Background: Major depressive disorder (MDD) is a common psychiatric disorder with a high prevalence of comorbidity with subclinical hypothyroidism. The aim of this study was to investigate the prevalence and factors influencing the comorbidity of subclinical hypothyroidism in patients with dyslipidemic MDD who were hospitalized for the first time in a Chinese population. Methods:The study incorporated 708 first-time hospitalized MDD patients, all with dyslipidemia. Data collection encompassed socio-demographic information, blood pressure, fasting blood glucose (FBG), lipid, and thyroid hormone levels. Participants were evaluated using the Hamilton Depression Scale (HAMD), Hamilton Anxiety Scale (HAMA), and Positive Symptom Subscale (PSS). Results: The prevalence of subclinical hypothyroidism in dyslipidemic MDD patients with the first hospitalization was 39.97%. The course of the disease, age at onset, HAMA score, and low-density lipoprotein cholesterol (LDL-C) were risk factors for subclinical hypothyroidism in dyslipidemic MDD patients. The course of disease, age at onset, HAMA score, HAMD score, FBG, and systolic blood pressure (SBP) levels were observed to influence serum Thyroid Stimulating Hormone (TSH) levels. Conclusion: MDD patients with dyslipidemia have a high prevalence of subclinical hypothyroidism, and the outcome is associated with anxiety, fasting glucose, and lipids. This study provides a potential biomarker for the identification of co-morbid subclinical hypothyroidism in MDD patients with dyslipidaemia.

A Cross-Sectional Study of the Relationship Between Perceived Stress and Thyroid Function Among Apparently Normal Women in the Reproductive Age

“…Hence, being married is linked to a higher likelihood of having SCH, possibly due to increased stress associated with married life. These observations were consistent with the observations of Zhan L, et al in their study [ 20 ]. Binary logistic regression for the phase of the menstrual cycle (secretory and proliferative) showed an odds ratio of 1.53, indicating that women in the secretory phase perceived a greater amount of stress, which is similar to the findings of Jain P, et al in their study.…”

Prevalence and clinical correlates of suicide attempts in patients with first-episode drug-naïve major depressive disorder and comorbid autoimmune thyroiditis

“…Consistent with our findings, previous studies have documented the substantial association of subclinical hypothyroidism with worse clinical symptoms in MDD. 24 – 26 Our results, if confirmed in further large-scale studies, highlight the importance of autoimmune thyroiditis severity levels in both clinical practice and future research.…”

“…Consistent with our findings, previous studies have documented the substantial association of subclinical hypothyroidism with worse clinical symptoms in MDD. [24][25][26] Our results, if confirmed in further large-scale studies, highlight the importance of autoimmune thyroiditis severity levels in both clinical practice and future research. Consistent with prior studies in patients with MDD, 10,12 we found significantly higher autoimmune thyroid antibodies and TSH levels in patients with a history of suicide attempt.…”

Increased thyroid stimulating hormone (TSH) as a possible risk factor for atherosclerosis in subclinical hypothyroidism

“…As well, LDL-induced endothelial dysfunction is implicated in the pathogenesis of AS [ 123 ]. Furthermore, subclinical PHT can trigger the development of endothelial dysfunction through the induction of dyslipidemia [ 124 ]. It has been illustrated that increasing TSH level in subclinical PHT is positively correlated with serum triglyceride, cholesterol, and LDL, and negatively correlated with serum HDL level [ 125 ].…”