Prevalence and factors associated with hidradenitis suppurativa: Results from two case-control studies

Revuz, J.; Canouï‐Poitrine, Florence; Wolkenstein, Pierre; Viallette, C.; Gabison, G.; Pouget, F.; Poli, F.; Faye, Ousmane; Roujeau, J C; Bonnélye, G.; Grob, Jean-Jacques; Bastuji‐Garin, Sylvie

doi:10.1016/j.jaad.2008.06.020

Cited by 564 publications

(648 citation statements)

References 9 publications

(6 reference statements)

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“…HS has been considered to be a rare disorder but European studies based on population samples using validated questionnaires have suggested a prevalence of 1%-2% in the general population and a peak prevalence of 4% (including mild cases) among young adults [4][5][6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Hidradenitis Suppurativa in General Practice: A Pilot Study

Benhadou¹

2015

J Gen Pract

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Section: Introductionmentioning

confidence: 99%

Hidradenitis Suppurativa in General Practice: A Pilot Study

Benhadou¹

2015

J Gen Pract

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“…A cne inversa (AI; also referred to as Hidradenitis suppurativa) is a chronic inflammatory skin disease with a prevalence rate of up to 4% (1)(2)(3)(4)(5)(6). It affects the intertriginous skin of perianal, inguinal, and axillary sites (2,5).…”

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confidence: 99%

Deficiency of IL-22 Contributes to a Chronic Inflammatory Disease: Pathogenetic Mechanisms in Acne Inversa

Wolk

Warszawska

Hoeflich

et al. 2011

The Journal of Immunology

227

283

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Overexpression of the T cell cytokine IL-22 is linked to the development of some chronic diseases, but little is known about IL-22 deficiency in humans. As demonstrated in this study, acne inversa (AI; also designated as Hidradenitis suppurativa) lesions show a relative deficiency of IL-22 and IL-20, but not of IL-17A, IL-26, IFN-γ, IL-24, or IL-1β. Moreover, AI lesions had reduced expression of membranous IL-22 and IL-20 receptors and increased expression of the natural IL-22 inhibitor, IL-22 binding protein. AI is a chronic inflammatory skin disease with prevalence up to 4% of the population and in which cutaneous bacterial persistence represents an important pathogenetic factor. Accordingly, we also found a relative deficiency of antimicrobial proteins (AMPs) in AI lesions and a positive correlation between lesional IL-22 and IL-20 versus AMP levels. IL-22, like its tissue cell downstream mediator IL-20, upregulated AMPs in reconstituted human epidermis and was critical for increased AMP levels under inflammatory conditions. The relative IL-22 deficiency in AI was not linked to lesional T cell numbers or Th22/Th1/Th17 subset markers and -inducing cytokines. However, IL-10 was highly expressed in AI lesions and correlated negatively with IL-22 expression. Moreover, IL-10 inhibited IL-22 but not IL-17 production in vitro. The IL-10 overexpression, in turn, was not associated with an elevated presence of regulatory T cells but with the enhanced presence of an IL-10–inducing cytokine. We conclude that IL-22 deficiency may contribute to the pathogenesis of certain chronic disorders as postulated in this paper for AI.

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“…It is more common in younger age groups 20s and 30s. (Revuz et al, 2008) HS can be diagnosed in patients by identifying deep-seated painful nodules, abscess, draining sinuses, scares or open comedones. The lesions in HS are deep seated and do not burst like simple boils.…”

mentioning

confidence: 99%

“…Smoking and obesity are recognized as important risk factors for HS (Revuz et al, 2008). The pathogenies of HS are not completely known.…”

mentioning

confidence: 99%