Prevalence and factors associated with hypertension in primary school children, in the centre region of Cameroon

Chelo, David; Mah, Evelyn; Chiabi, Edmond N.; Chiabi, Andréas; Ndombo, Paul Olivier Koki; Kingué, Samuel; Obama, Marie-Thérèse

doi:10.21037/tp.2019.03.02

Cited by 19 publications

(33 citation statements)

References 21 publications

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“…The reported high prevalence of hypertension as well as an elevated blood pressure were previously observed in this setting [30]. We did not nd any association between BW and BP overall as well as with SBP or DBP as reported earlier [29,30].…”

Section: Discussionsupporting

confidence: 56%

“…In Cameroon, CKD is highly prevalent in adult populations, ranging from 10 to 14.2% and driven by known modi able risk factors for chronic nephropathy [27,28]. In children, studies revealed no association between BW and blood pressure (BP) [29,30]. However, no study had yet assessed the spectrum of renal markers according to BW among children.…”

Section: Introductionmentioning

confidence: 99%

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Birth weight and renal markers in children aged 5 – 10 years in Cameroon: A cross-sectional study

Kaze

Nguefack²,

Asong

et al. 2020

Preprint

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Background A relationship exists between birth weight (BW) and glomerular filtration rate (GFR) in postnatal kidney. Willing to fill a gap of knowledge in sub-Saharan Africa, we assessed the effect of BW on blood pressure (BP), proteinuria and GFR among Cameroonians children.Methods This was a cross-sectional hospital-based study from January to April 2018 at the Yaounde Gynaeco-Obstetric and Paediatric Hospital (YGOPH). We recruited low BW (LBW) [<2500g], normal BW (NBW) [2500-3999g] and high BW (HBW) [>4000g] children, aged 5-10 years, born and followed-up at YGOPH. We collected socio-demographic, clinical (weight, height, BP), laboratory (proteinuria, creatinine), maternal and birth data. The estimated GFR was calculated using the Schwartz equation.Results We included 80 children (61.2% boys) with 21 (26.2%) LBW, 45 (56.2%) NBW and 14 (15.5%) HBW; the median (interquartile range) age was 7.3 (6.3-8.1) years and 17 (21.2%) were overweight/obese. Two (2.5%) children, all with a NBW (4.4%), had an elevated BP whereas 2 (2.5%) other children, all with a LBW (9.5%), had hypertension (p=0.233). Seven (8.7%) children had proteinuria with 19%, 2.2% and 14.3% having LBW, NBW and HBW, respectively (p=0.051). Equivalent figures were 18 (22.5%), 14.3%, 24.2% and 28.6% for decreased GFR, respectively (p=0.818). There was a trend towards an inverse relationship between BW and BP, proteinuria and GFR (p>0.05). Conclusion Proteinuria is more pronounced in childhood with a history of LBW and HBW while LBW children are more prone to develop hypertension. Regular follow-up is needed to implement early nephroprotective measures among children with abnormal BW.

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Section: Discussionsupporting

confidence: 56%

Section: Introductionmentioning

confidence: 99%

Birth weight and renal markers in children aged 5 – 10 years in Cameroon: A cross-sectional study

Kaze

Nguefack²,

Asong

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…The reported high prevalence of hypertension as well as an elevated blood pressure were previously observed in this setting [ 30 ]. We did not find any association between BW and BP overall as well as with SBP or DBP as reported earlier [ 29 , 30 ]. However, we found that all children with hypertension were of the LBW group, which could be explained by the Brenner’s hypothesis.…”

Section: Discussionmentioning

confidence: 68%

“…In Cameroon, CKD is highly prevalent in adult populations, ranging from 10 to 14.2% and driven by known modifiable risk factors for chronic nephropathy [ 27 , 28 ]. In children, studies revealed no association between BW and blood pressure (BP) [ 29 , 30 ]. However, no study had yet assessed the spectrum of renal markers according to BW among children.…”

Section: Introductionmentioning

confidence: 99%

Birth weight and renal markers in children aged 5–10 years in Cameroon: a cross-sectional study

et al. 2020

View full text Add to dashboard Cite

Background A relationship exists between birth weight (BW) and glomerular filtration rate (GFR) in postnatal kidney. Willing to fill a gap of knowledge in sub-Saharan Africa, we assessed the effect of BW on blood pressure (BP), proteinuria and GFR among Cameroonians children. Methods This was a cross-sectional hospital-based study from January to April 2018 at the Yaounde Gynaeco-Obstetric and Paediatric Hospital (YGOPH). We recruited low BW (LBW) [< 2500 g], normal BW (NBW) [2500-3999 g] and high BW (HBW) [> 4000 g] children, aged 5–10 years, born and followed-up at YGOPH. We collected socio-demographic, clinical (weight, height, BP), laboratory (proteinuria, creatinine), maternal and birth data. The estimated GFR was calculated using the Schwartz equation. Results We included 80 children (61.2% boys) with 21 (26.2%) LBW, 45 (56.2%) NBW and 14 (15.5%) HBW; the median (interquartile range) age was 7.3 (6.3–8.1) years and 17 (21.2%) were overweight/obese. Two (2.5%) children, all with a NBW (4.4%), had an elevated BP whereas 2 (2.5%) other children, all with a LBW (9.5%), had hypertension (p = 0.233). Seven (8.7%) children had proteinuria with 19, 2.2 and 14.3% having LBW, NBW and HBW, respectively (p = 0.051). Equivalent figures were 18 (22.5%), 14.3, 24.2 and 28.6% for decreased GFR, respectively (p = 0.818). There was a trend towards an inverse relationship between BW and BP, proteinuria and GFR (p > 0.05). Conclusion Proteinuria is more pronounced in childhood with a history of LBW and HBW while LBW children are more prone to develop hypertension. Regular follow-up is needed to implement early nephroprotective measures among children with abnormal BW.

show abstract

“…In Cameroon, CKD is highly prevalent in adult's populations ranging from 10 to 14.2% driven by known modifiable risk factors for chronic nephropathy [27,28]. In children, studies revealed no association between BW and blood pressure [29,30]. However, no study had yet assessed the spectrum of renal markers according to BW among children.…”

Section: Introductionmentioning

confidence: 99%

Birth Weight and Renal Markers in Children Aged 5 – 10 Years in Cameroon: A Cross-Sectional Study

Kaze

Nguefack²,

Asong

et al. 2020

Preprint

View full text Add to dashboard Cite

Background A relationship exists between the birth weight (BW) and the glomerular filtration rate (GFR) in postnatal kidney. Willing to fill a gap of knowledge in sub-Saharan Africa, we assessed the effect of BW on blood pressure (BP), proteinuria and GFR among Cameroonians children. Methods This was a cross-sectional hospital-based study from January to April 2018 at the Yaounde Gynaeco-Obstetric and Paediatric Hospital (YGOPH). We recruited low BW (LBW) [<2500g], normal BW (NBW) [2500-3999g] and high BW (HBW) [>4000g] children, aged 5-10 years, born and followed-up at YGOPH. We collected socio-demographic, clinical (weight, height, BP), laboratory (proteinuria, creatinine), maternal and birth data. The estimated GFR was calculated using Schwartz equation. Results We included 80 children (61.2% boys) with 21 (26.2%) LBW, 45 (56.2%) NBW and 14 (15.5%) HBW; the median (interquartile range) age was 7.3 (6.3-8.1) years and 17 (21.2%) were overweight/obese. Two (2.5%) children, all with a NBW (4.4%), had an elevated BP whereas 2 (2.5%) others children, all with a LBW (9.5%), had hypertension (p=0.233). Seven (8.7%) children had proteinuria with 19%, 2.2% and 14.3% having LBW, NBW and HBW respectively (p=0.051). Equivalents figures were 18 (22.5%), 14.3%, 24.2% and 28.6% for decrease GFR (p=0.818). There was a trends towards an inverse relationship between BW and BP, proteinuria and GFR (p>0.05). Conclusion Proteinuria is more pronounced in childhood with history of LBW and HBW while LBW children are more prone to develop hypertension. Regular follow-up is needed to implement early nephroprotective measures among children with abnormal BW.

show abstract

Prevalence and factors associated with hypertension in primary school children, in the centre region of Cameroon

Cited by 19 publications

References 21 publications

Birth weight and renal markers in children aged 5 – 10 years in Cameroon: A cross-sectional study

Birth weight and renal markers in children aged 5 – 10 years in Cameroon: A cross-sectional study

Birth weight and renal markers in children aged 5–10 years in Cameroon: a cross-sectional study

Birth Weight and Renal Markers in Children Aged 5 – 10 Years in Cameroon: A Cross-Sectional Study

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