Prevalence and factors associated with symptom persistence: A prospective study of 429 mild COVID-19 outpatients

Fayçal, Antoine; Ndoadoumgue, Aude Laetitia; Sellem, B; Blanc, Catherine; Dudoit, Yasmine; Schneider, Lara; Tubiana, Roland; Valantin, M.A.; Seang, Sophie; Palich, Romain; Bleibtreu, Alexandre; Monsel, Gentiane; Godefroy, N.; Paccoud, Olivier; Pourcher, Valérie; Caumes, Éric; Ktorza, Nadine; Chermak, Aziza; Assoumou, Lambert

doi:10.1016/j.idnow.2021.11.003

Cited by 8 publications

(16 citation statements)

References 38 publications

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“…Based on the duration of follow-up (<3 months, >3 months), there were no significant differences in frequency of GI symptoms between these two groups. The frequency of GI symptoms in studies reporting a follow-up of less than 3 months was 0.11 (95% CI, 0.02–0.38, I 2 = 98%) while for studies with more than 3 months of follow-up it was 0.12 (95% CI, 0.06–0.22, I 2 = 100%) 13 , 14 , 27 , 28 , 39 , 40 , 42 , 45 , 48 , 49 , 51 , 55 , 59 , 60 ( Supplemental Figure 5 ). Subgroup analysis on the basis of mode of follow-up suggested a slightly higher frequency of symptoms with telephonic follow-up [0.14 (95% CI, 0.06–0.31, I 2 = 98%)] as compared to in person follow-up [0.04 (95% CI, 0.01–0.19, I 2 = 98%)] 13 , 14 , 27 , 28 , 39 , 40 , 42 , 45 , 48 , 49 , 51 , 55 , 59 , 60 ( Supplemental Figure 6 ).…”

Section: Resultsmentioning

confidence: 99%

“…Table 1 shows the details of the included studies with the study design, type of population, symptoms, duration, and the information provided. 13 – 62 Supplemental Table 2 shows the excluded studies with reasons of exclusion.…”

Section: Resultsmentioning

confidence: 99%

“…The overall frequency of GI symptoms was reported in 14 studies involving 296,487 patients. 13 , 14 , 27 , 28 , 39 , 40 , 42 , 45 , 48 , 49 , 51 , 55 , 59 , 60 The frequency of overall GI symptoms in patients with COVID-19 was 0.12 [95% confidence interval (CI), 0.06–0.22, I 2 = 99%] ( Figure 2 ). The frequency of GI symptoms in long COVID was reported in 12 studies (158,731 patients).…”

Section: Resultsmentioning

confidence: 99%

“…The frequency of GI symptoms in long COVID was reported in 12 studies (158,731 patients). 13 , 14 , 27 , 28 , 39 , 40 , 42 , 45 , 51 , 52 , 53 , 55 The frequency of GI symptoms in patients with long COVID was 0.22 (95% CI, 0.10–0.41, I 2 = 97%) ( Figure 2 ).…”

Section: Resultsmentioning

confidence: 99%

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Gastrointestinal manifestations of long COVID: A systematic review and meta-analysis

Choudhury

Tariq

Jena

et al. 2022

Therap Adv Gastroenterol

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Background: Prolonged symptoms after COVID-19 are an important concern due to the large numbers affected by the pandemic. Objectives: To ascertain the frequency of gastrointestinal (GI) manifestations as part of long GI COVID. Design: A systematic review and meta-analysis of studies reporting GI manifestations in long COVID was performed. Data Sources and Methods: Electronic databases (Medline, Scopus, Embase, Cochrane Central Register of Controlled Trials, and Web of Science) were searched till 21 December 2021 to identify studies reporting frequency of GI symptoms in long COVID. We included studies reporting overall GI manifestations or individual GI symptoms as part of long COVID. We excluded pediatric studies and those not providing relevant information. We calculated the pooled frequency of various symptoms in all patients with COVID-19 and also in those with long COVID using the inverse variance approach. All analysis was done using R version 4.1.1 using packages ‘meta’ and ‘metafor’. Results: A total of 50 studies were included. The frequencies of GI symptoms were 0.12 [95% confidence interval (CI), 0.06–0.22, I2 = 99%] and 0.22 (95% CI, 0.10–0.41, I2 = 97%) in patients with COVID-19 and those with long COVID, respectively. The frequencies of abdominal pain, nausea/vomiting, loss of appetite, and loss of taste were 0.14 (95% CI, 0.04–0.38, I2 = 96%), 0.06 (95% CI, 0.03–0.11, I2 = 98%), 0.20 (95% CI, 0.08–0.43, I2 = 98%), and 0.17 (95% CI, 0.10–0.27, I2 = 95%), respectively, after COVID-19. The frequencies of diarrhea, dyspepsia, and irritable bowel syndrome were 0.10 (95% CI, 0.04–0.23, I2 = 98%), 0.20 (95% CI, 0.06–0.50, I2 = 97%), and 0.17 (95% CI, 0.06–0.37, I2 = 96%), respectively. Conclusion: GI symptoms in patients were seen in 12% after COVID-19 and 22% as part of long COVID. Loss of appetite, dyspepsia, irritable bowel syndrome, loss of taste, and abdominal pain were the five most common GI symptoms of long COVID. Significant heterogeneity and small number of studies for some of the analyses are limitations of the systematic review.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Gastrointestinal manifestations of long COVID: A systematic review and meta-analysis

Choudhury

Tariq

Jena

et al. 2022

Therap Adv Gastroenterol

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“…A recent report ( 33 ) also highlighted fatigue, dyspnea, cough, headache, loss of taste and/or smell, and cognitive or mental health impairment as the most common symptoms in people with post-acute sequelae of SARS-CoV-2 infection. Moreover, age > 40 years, female sex, reverse transcription PCR (RT-PCR) low cycle threshold (Ct) values, and ageusia have been reported to be associated with persistent symptoms after COVID-19 in adults ( 34 ).…”

Section: From Acute Disease To Post-covid-19 Conditionmentioning

confidence: 99%

Post COVID-19 Condition in Children and Adolescents: An Emerging Problem

et al. 2022

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The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection became a pandemic in 2020 and by March 2022 had caused more than 479 million infections and 6 million deaths worldwide. Several acute and long-term symptoms have been reported in infected adults, but it remains unclear whether children/adolescents also experience persistent sequelae. Hence, we conducted a review of symptoms and pathophysiology associated with post-coronavirus disease 2019 (post-COVID-19) condition in children and adolescents. We reviewed the scientific literature for reports on persistent COVID-19 symptoms after SARS-CoV-2 infection in both children/adolescents and adults from 1 January 2020 to 31 March 2022 (based on their originality and relevance to the broad scope of this review, 26 reports were included, 8 focused on adults and 18 on children/adolescents). Persistent sequelae of COVID-19 are less common in children/adolescents than in adults, possibly owing to a lower frequency of SARS-CoV-2 infection and to the lower impact of the infection itself in this age group. However, cumulative evidence has shown prolonged COVID-19 to be a clinical entity, with few pathophysiological associations at present. The most common post-COVID-19 symptoms in children/adolescents are fatigue, lack of concentration, and muscle pain. In addition, we found evidence of pathophysiology associated with fatigue and/or headache, persistent loss of smell and cough, and neurological and/or cardiovascular symptoms. This review highlights the importance of unraveling why SARS-CoV-2 infection may cause post-COVID-19 condition and how persistent symptoms might affect the physical, social, and psychological well-being of young people in the future.

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Susceptibility and infectiousness of SARS-CoV-2 in children versus adults, by variant (wild-type, Alpha, Delta): a systematic review and meta-analysis of household contact studies

Uthman

Lyngse

Anjorin

et al. 2022

Preprint

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Importance: Understanding the susceptibility and infectiousness of children and adolescents in comparison to adults is important to appreciate their role in the COVID-19 pandemic. Objective: To determine SARS-CoV-2 susceptibility and infectiousness of children and adolescents with adults as comparator for three variants (wild-type, Alpha, Delta) in the household setting. We aimed to identify the effects independent of vaccination. Data Sources: We searched EMBASE, PubMed and medRxiv up to January 2022. Additional studies were identified through contacting subject experts. Study Selection: Two reviewers independently identified studies providing secondary attack rates (SAR) for SARS-CoV-2 infection in children (0-9 years), adolescents (10-19 years) or both compared with adults (20 years and older) derived from household data. Data Extraction and Synthesis: Two reviewers independently performed data extraction. We assessed risk of bias of included studies using a critical appraisal checklist and a random-effects meta-analysis model to pool association estimates. Main Outcomes and Measures: Odds ratio (OR) for SARS-CoV-2 infection comparing children and adolescents with adults stratified by wild-type, Alpha, and Delta variant, respectively. Susceptibility was defined as the secondary attack rate (SAR) among susceptible household contacts irrespective of the age of the index case. Infectiousness was defined as the SAR irrespective of the age of household contacts when children/adolescents/adults were the index case. Results: Twenty-eight studies (308,857 contacts) were included in the susceptibility analysis, for Delta only one (large) study was available. Compared to adults children and adolescents were less susceptible to the wild-type and Delta variant, but equally susceptible to the Alpha variant. In the infectiousness analysis, 21 studies (201,199 index cases) were included. Compared to adults, children and adolescents were less infectious when infected with the wild-type and Delta variant. Alpha variant-related infectiousness remained unclear, 0-9 year old children were at least as infectious as adults. SAR among household contacts was highest during circulation of the Alpha variant, lowest during wild-type circulation and intermediate during Delta circulation. Conclusions and Relevance: When considering the potential role of children and adolescents, for each variant susceptibility, infectiousness, age group and overall transmissibility need to be assessed to guide public health policy.

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Prevalence and factors associated with symptom persistence: A prospective study of 429 mild COVID-19 outpatients

Cited by 8 publications

References 38 publications

Gastrointestinal manifestations of long COVID: A systematic review and meta-analysis

Gastrointestinal manifestations of long COVID: A systematic review and meta-analysis

Post COVID-19 Condition in Children and Adolescents: An Emerging Problem

Susceptibility and infectiousness of SARS-CoV-2 in children versus adults, by variant (wild-type, Alpha, Delta): a systematic review and meta-analysis of household contact studies

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