Prevalence and factors associated with rheumatic diseases and chronic joint symptoms in the elderly

Falsarella, Gláucia Regina; Coimbra, Ibsen Bellini; Barcelos, Caroline Coutinho de; Costallat, Lílian Tereza Lavras; Carvalho, Olga Maria Fernandes de; Coimbra, Arlete Maria Valente

doi:10.1111/ggi.12052

Cited by 13 publications

(19 citation statements)

References 33 publications

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“…Rheumatic diseases are considered a common cause of disability and represent high costs to public health in Brazil and the United States . Nonsteroidal anti‐inflammatory drugs are used in the treatment of arthritis, but in recent years biological and conventional disease‐modifying anti‐rheumatic drugs (DMARDs) became a new option for treatment.…”

Section: Discussionmentioning

confidence: 99%

“…Rheumatic diseases are considered a common cause of disability and represent high costs to public health in Brazil and the United States. 38,39 Nonsteroidal anti-inflammatory drugs are used in the F I G U R E 5 Treatment with CXCL9(74-103) at late time points has no effect on cell recruitment to the joint in antigen-induced arthritis. Mice were immunized with mBSA and CFA and were challenged i.a.…”

Section: Discussionmentioning

confidence: 99%

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The chemokine fragment CXCL9(74–103) diminishes neutrophil recruitment and joint inflammation in antigen-induced arthritis

Boff

Crijns

Janssens

et al. 2018

Journal of Leukocyte Biology

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This study investigates if treatment with a peptide corresponding to the 30 C-terminal amino acids of CXCL9, CXCL9(74-103), ameliorates joint inflammation in a murine model of antigen-induced arthritis (AIA). AIA was induced in male C57BL/6J mice. Intravenous injection of CXCL9(74-103), simultaneously performed with a tibiofemoral challenge with methylated BSA (mBSA) as antigen in mice immunized with mBSA, diminished the accumulation of leukocytes, in particular neutrophils, in the synovial cavity. The levels of the chemokines CXCL1, CXCL2, and CXCL6 and of the cytokine IL-6 were decreased in inflamed periarticular tissue of mice treated with the CXCL9-derived peptide compared to non-treated AIA mice. In addition, CXCL9(74-103) treatment substantially reduced joint and cartilage damage. CXCL9(74-103) competes with CXCL6 and CCL3 for binding to the glycosaminoglycans heparan sulfate and chondroitin sulfate in vitro. In vivo, CXCL9(74-103) quickly binds to blood vessels in joints as observed by confocal microscopy. Next, we evaluated if later treatment with CXCL9(74-103) had a beneficial impact on joint inflammation. CXCL9(74-103) injection 6 h after mBSA challenge still reduced neutrophil accumulation in the joint, although it did not reduce chemokine and IL-6 concentrations. However, a delay of treatment until 12 h after challenge had no effect on cell recruitment and chemokine and IL-6 levels. Taken together, we demonstrated that treatment with a peptide, which interferes with the interaction between chemokines and glycosaminoglycans, from the beginning of the disease controlled the massive accumulation of neutrophils in the joint of AIA mice, greatly impacting on joint inflammation and tissue damage.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

The chemokine fragment CXCL9(74–103) diminishes neutrophil recruitment and joint inflammation in antigen-induced arthritis

Boff

Crijns

Janssens

et al. 2018

Journal of Leukocyte Biology

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“…Some of these relationships have been studied independently in some conditions. For example, diabetes is related to cataracts and diabetic retinopathy, and arthritis has been associated with a higher risk of cataracts [20, 53, 54]. However, it is known that not only diabetes but also hypertension and hypercholesterolemia are risk factors for diabetic retinopathy so, in this case, cumulative effects are possible [55, 56].…”

Section: Discussionmentioning

confidence: 99%

Visual impairment and multimorbidity in a representative sample of the Spanish population

et al. 2014

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BackgroundIn the context of population aging, visual impairment has emerged as a growing concern in public health. However, there is a need for further research into the relationship between visual impairment and chronic medical conditions in the elderly. The aim of our study was to examine the relationship between visual impairment and three main types of co-morbidity: chronic physical conditions (both at an independent and additive level), mental health and cognitive functioning.MethodsData were collected from the COURAGE in Europe project, a cross-sectional study. A total of 4,583 participants from Spain were included. Diagnosis of chronic medical conditions included self-reported medical diagnosis and symptomatic algorithms. Depression and anxiety were assessed using CIDI algorithms. Visual assessment included objective distance/near visual acuity and subjective visual performance. Descriptive analyses included the whole sample (n = 4,583). Statistical analyses included participants aged over 50 years (n = 3,625; mean age = 66.45 years) since they have a significant prevalence of chronic conditions and visual impairment. Crude and adjusted binary logistic regressions were performed to identify independent associations between visual impairment and chronic medical conditions, physical multimorbidity and mental conditions. Covariates included age, gender, marital status, education level, employment status and urbanicity.ResultsThe number of chronic physical conditions was found to be associated with poorer results in both distance and near visual acuity [OR 1.75 (CI 1.38-2.23); OR 1.69 (CI 1.27-2.24)]. At an independent level, arthritis, stroke and diabetes were associated with poorer distance visual acuity results after adjusting for covariates [OR 1.79 (CI 1.46-2.21); OR 1.59 (CI 1.05-2.42); OR 1.27 (1.01-1.60)]. Only stroke was associated with near visual impairment [OR 3.01 (CI 1.86-4.87)]. With regard to mental health, poor subjective visual acuity was associated with depression [OR 1.61 (CI 1.14-2.27); OR 1.48 (CI 1.03-2.13)]. Both objective and subjective poor distance and near visual acuity were associated with worse cognitive functioning.ConclusionsArthritis, stroke and the co-occurrence of various chronic physical diseases are associated with higher prevalence of visual impairment. Visual impairment is associated with higher prevalence of depression and poorer cognitive function results. There is a need to implement patient-centered care involving special visual assessment in these cases.

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“…These results are similar to those observed in other studies. 7,9,10 Aging promotes a physiological wear of the joints that, combined with insufficiency in the repair of articular cartilage, mainly in the presence of comorbidities, 25,26 can render the prevalence higher in older individuals.…”

Section: Discussionmentioning

confidence: 99%

“…In these studies, prevalence rates were respectively 44.2% among elderly individuals from Minas Gerais 8 and 45.6% in an elderly population from São Paulo. 9 With adult populations, to date, the only study found was conducted by Silva et al, 10 who identified a prevalence of 36.5% in the south of Brazil.…”

Section: Introductionmentioning

confidence: 99%

Chronic joint symptoms in adults: A population-based study

Morais

Segheto

Silva

et al. 2017

Rev. Assoc. Med. Bras.

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Prevalence and factors associated with rheumatic diseases and chronic joint symptoms in the elderly

Cited by 13 publications

References 33 publications

The chemokine fragment CXCL9(74–103) diminishes neutrophil recruitment and joint inflammation in antigen-induced arthritis

The chemokine fragment CXCL9(74–103) diminishes neutrophil recruitment and joint inflammation in antigen-induced arthritis

Visual impairment and multimorbidity in a representative sample of the Spanish population

Chronic joint symptoms in adults: A population-based study

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