Prevalence and factors associated with late diagnosis among older adults living with HIV in liuzhou, China: 2010−2020

Chu, Qinshu; Zhang, Xinhong; Lan, Jianguo; Zhang, Qi; Tao, Wei; Fu, Yuansheng; Fan, Yin‐Guang

doi:10.1002/jmv.28288

Cited by 3 publications

(2 citation statements)

References 25 publications

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“…The NSTMP is considered to be the most important scientific and research project in China. Its infectious disease prevention and control projects have been carried out in Guangxi for decades to assess the key issues in the HIV epidemic,21 22 including the low willingness of the population to be screened and the high mortality rate in rural areas due to late HIV detection and diagnosis 23 24. We conducted the study to estimate the diagnostic validity and acceptance of a rapid urine HIV antibody test kit in different populations.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic performance evaluation of urine HIV-1 antibody rapid test kits in a real-life routine care setting in China

Lu,

Chen,

Liang

et al. 2024

BMJ Open

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ObjectivesTo evaluate the diagnostic performance of urine HIV antibody rapid test kits in screening diverse populations and to analyse subjects’ willingness regarding reagent types, purchase channels, acceptable prices, and self-testing.DesignsDiagnostic accuracy studiesParticipantsA total of 2606 valid and eligible samples were collected in the study, including 202 samples from female sex workers (FSWs), 304 persons with injection drug use (IDU), 1000 pregnant women (PW), 100 subjects undergoing voluntary HIV counselling and testing (VCT) and 1000 students in higher education schools or colleges (STUs). Subjects should simultaneously meet the following inclusion criteria: (1) being at least 18 years old and in full civil capacity, (2) signing an informed consent form and (3) providing truthful identifying information to ensure that the subjects and their samples are unique.ResultsThe sensitivity, specificity and area under the curve (AUC) of the urine HIV-1 antibody rapid test kits were 92.16%, 99.92% and 0.960 (95% CI: 0.952 to 0.968, p<0.001), respectively, among 2606 samples collected during on-site screenings. The kits showed good diagnostic performance in persons with IDU (AUC, 1.000; 95% CI, 1.000 to 1.000, p<0.001), PW (AUC, 0.999; 95% CI, 0.999 to 1.000, p<0.001) and FSWs (AUC, 1.000; 95% CI, 1.000 to 1.000, p<0.001). The AUC of the urine reagent kits in subjects undergoing VCT was 0.941 (95% CI: 0.876 to 0.978, p<0.001). The ‘acceptable price’ had the greatest influence on STUs (Pi=1.000) and PW (Pi=1.000), the ‘purchase channel’ had the greatest influence on subjects undergoing VCT (Pi=1.000) and persons with IDU (Pi=1.000) and the ‘reagent types’ had the greatest influence on FSWs (Pi=1.000).ConclusionsThe rapid urine test kits showed good diagnostic validity in practical applications, despite a few cases involving misdiagnosis and underdiagnosis.

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Section: Discussionmentioning

confidence: 99%

Diagnostic performance evaluation of urine HIV-1 antibody rapid test kits in a real-life routine care setting in China

Lu,

Chen,

Liang

et al. 2024

BMJ Open

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“…Our study is one of the few developed in our country that evaluates sexuality in OP, in addition, the importance of sexuality in relation to prevention or detection of sexually transmitted diseases should be emphasized, since they are not immune to these infectious agents, in addition to the fact that there are reports of increased rates of sexually transmitted infections. 26 Speaking of people living with HIV, OP are perceived as a group with a lower risk of contracting the infection, as a consequence, almost half of OP living with HIV are diagnosed late and this presentation causes OP to receive care delay, and everything that this infection involves, the increase in polypharmacy, premature and pathological aging, greater risk of prevalence of frailty, greater risk of falls and greater prevalence of cognitive impairment; hence, it goes beyond the impact of the infection itself 27,28 .…”

Section: Discussionmentioning

confidence: 99%

Relationship between age and sexual activity in the elderly attended in a second-level hospital in Mexico

García-Villaseñor,

Duarte-Flores,

Pacheco-Magaña

2024

LAGM

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Older people (OP) continue to be sexually active and sexual experiences have been associated with the preservation of psychological and physical well-being. Objective: The objective of this study was to determine the existence of a relationship between the frequency of sexual activity and age. Materials and methods: Descriptive, cross-sectional, and quantitative study, through a survey, carried out in a second-level Hospital in the geriatrics service, in Mexico. Results: Ninety-two subjects were included, with a mean age of 77.7 ± 8 years, 64.1% had a partner, and 44.6% of the total maintained sexual activity, determining that the subjects who are at younger ages located in the age group between 65 and 79 years, there is the highest percentage of subjects with sexual activity (35.9%) (p < 0.001), 88% of the subjects registered presenting some problem that hinders their sexual activity. Conclusion:The OP in our population continues to present sexual activity, age being an important but not determining factor for people to maintain an active sexual life.

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Multi-level Factors Associated with HIV Late Presentation with Advanced Disease and Delay Time of Diagnosis in South Carolina, 2005–2019

Shi,

Zhang,

Chen

et al. 2024

AIDS Behav

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This study explored individual- and county-level risk factors of late presentation with advanced disease (LPAD) among people with HIV (PWH) and their longer delay time from infection to diagnosis in South Carolina (SC), using SC statewide Enhanced HIV/AIDS Reporting System (eHARS). LPAD was defined as having an AIDS diagnosis within three months of initial HIV diagnosis, and delay time from HIV infection to diagnosis was estimated using CD4 depletion model. 3,733 (41.88%) out of 8,913 adult PWH diagnosed from 2005 to 2019 in SC were LPAD, and the median delay time was 13.04 years. Based on the generalized estimating equations models, PWH who were male (adjusted prevalence ratio [aPR]: 1.22, 95% CI: 1.12 ∼ 1.33), aged 55+ (aPR: 1.76, 95% CI: 1.62 ∼ 1.92), were Black (aPR: 1.09, 95% CI: 1.03 ∼ 1.15) or Hispanic (aPR: 1.42, 95% CI: 1.26 ∼ 1.61), and living in counties with a larger proportion of unemployment individuals (aPR: 1.02, 95% CI: 1.01 ∼ 1.03) were more likely to be LPAD. Among PWH who were LPAD, Hispanic (adjusted beta: 1.17, 95% CI: 0.49 ∼ 1.85) instead of Black (adjusted beta: 0.11, 95% CI: -0.30 ∼ 0.52) individuals had significant longer delay time compared to White individuals. Targeted and sustained interventions are needed for older, male, Hispanic or Black individuals and those living in counties with a higher percentage of unemployment because of their higher risk of LPAD. Additionally, specific attention should be paid to Hispanic individuals due to their longer delay time to diagnosis.

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Prevalence and factors associated with late diagnosis among older adults living with HIV in liuzhou, China: 2010−2020

Cited by 3 publications

References 25 publications

Diagnostic performance evaluation of urine HIV-1 antibody rapid test kits in a real-life routine care setting in China

Diagnostic performance evaluation of urine HIV-1 antibody rapid test kits in a real-life routine care setting in China

Relationship between age and sexual activity in the elderly attended in a second-level hospital in Mexico

Multi-level Factors Associated with HIV Late Presentation with Advanced Disease and Delay Time of Diagnosis in South Carolina, 2005–2019

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