Prevalence and factors associated with nonalcoholic fatty pancreas disease and its severity in China

Weng, Siying; Jian-yang, Zhou; Chen, Xiabo; Sun, Yihong; Mao, Zhu-Jun; Ke-fu, Chai

doi:10.1097/md.0000000000011293

Cited by 48 publications

(49 citation statements)

References 31 publications

(35 reference statements)

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“…There were 10 studies reporting on the proportion of DM individuals in the presence or absence of NAFPD. One thousand ninety five individuals had DM in 5550 individuals with NAFPD; 4097 individuals had DM in 43 863 individuals without NAFPD.…”

Section: Resultsmentioning

confidence: 99%

“…Nine studies provided data on the proportion of MetS subjects with hypertension, with or without NAFPD. One thousand, five hundred fifty eight individuals had hypertension in 5264 NAFPD‐positive population; 8758 individuals had hypertension in 43 721 NAFPD‐negative individuals.…”

Section: Resultsmentioning

confidence: 99%

“…Similarly, 9 studies provided data on the proportion of individuals with NAFLD in the presence or absence of NAFPD. Three thousand five hundred four individuals had NAFLD in 5327 NAFPD‐positive population; 15 535 individuals had NAFLD in 43 109 NAFPD‐negative populations.…”

Section: Resultsmentioning

confidence: 99%

“…Six studies provided data on the proportion of subjects on central obesity, with or without NAFPD. Three thousand five hundred seventy three individuals had central obesity in 4980 NAFPD‐positive population; 18 415 individuals had central obesity in 42 806 NAFPD‐negative populations.…”

Section: Resultsmentioning

confidence: 99%

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The association between pancreas steatosis and metabolic syndrome: A systematic review and meta‐analysis

Wang

et al. 2019

Diabetes Metabolism Res

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Objectives: Pancreas steatosis is the description of fat accumulation in the pancreatic gland. The prevalence and development mechanisms of pancreatic steatosis in patients with metabolic disorders still remain unclear. The aim of this study is to systematically review the association between pancreatic steatosis and metabolic comorbidities.Methods: We performed a systematic search strategy using three electronic databases (MEDLINE, Scopus, and Embase) for relevant studies concerning the associations of pancreatic steatosis with metabolic syndrome (MetS) and its clinical relevance from inception until 30 September 2018.Results: One thousand three hundred fifty one references were identified in the initial search, and a total of 13 studies involving 49 329 subjects were included. This analyses elucidated the presence of non-alcoholic fatty pancreas disease (NAFPD) and was associated with a significant increased risk of metabolic syndrome (RR = 2.25; 95% CI, 2.00-2.53; P < 0.0001; I 2 = 42.8%; eight studies included), hypertension (RR = 1.43; 95% CI, 1.08-1.90; P = 0.013; I 2 = 94.7%; nine studies included), nonalcoholic fatty liver disease (NAFLD) (RR = 2.49; 95% CI, 2.06-3.02; P < 0.0001; I 2 = 96.9%; nine studies included), diabetes mellitus (RR = 1.99; 95% CI, 1.18-3.35; P = 0.01; I 2 = 97.6%; 10 studies included), and central obesity (RR = 1.91; 95% CI, 1.67-2.19; P < 0.0001; I 2 = 95.9%; six studies included). The association between NAFPD and hyperlipidaemia was not statistically significant (RR = 1.33; 95% CI, 0.82-2.17; P = 0.249; I 2 = 97%; five studies included). Conclusions:The existing evidence indicates that NAFPD is significantly associated with an increased risk of metabolic syndrome and its components. Well-designed prospective cohort studies between pancreatic steatosis and MetS are needed to elaborate the causality in the future. KEYWORDS fatty pancreas, metabolic syndrome, non-alcoholic fatty pancreas disease, pancreatic steatosis Abbreviations: BMI, body mass index; CI, confidence interval; DM, diabetes mellitus; MetS, metabolic syndrome; MRI, magnetic resonance imaging; MRS, magnetic resonance spectrum.; NAFLD, Non-alcoholic fatty liver disease; NAFPD, Non-alcoholic fatty pancreas disease; RR, relative risk

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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The association between pancreas steatosis and metabolic syndrome: A systematic review and meta‐analysis

Wang

et al. 2019

Diabetes Metabolism Res

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“…Although there is increasing evidence describing the association of metabolic syndrome with NAFPD, unlike NAFLD, the effect of metabolic syndrome on the pancreas has not been well characterized. Per a Chinese study, type 2 DM, obesity, and the Homeostatic Model Assessment of Insulin Resistance (HOMA‐IR) were shown to be independent risk factor for NAFPD . NAFPD, as compared with NAFLD, predominantly undergoes fat deposition via infiltration by adipocytes .…”

Section: Similarities and Differences Between Nafpd And Nafldmentioning

confidence: 99%

Nonalcoholic Fatty Pancreas Disease

Shah

Rocha²,

Bhutiani

et al. 2019

Nut in Clin Prac

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Nonalcoholic fatty pancreas disease (NAFPD) describes a phenotype of pancreatic steatosis (PS) that is not caused by alcohol consumption, viral infections, toxins, or congenital metabolic syndromes but is associated with insulin resistance, malnutrition, obesity, metabolic syndrome, or increasing age. NAFPD is a relatively new disease entity, as the clinical significance of fatty infiltration of pancreas has gained attention recently. Clinical consequences of NAFPD remain largely unknown despite clinical associations. This review aims to study similarities and differences between hepatic and PS and explore recent advances in NAFPD. (Nutr Clin Pract. 2019;34(suppl 1):S49-S56) Keywords fatty liver; fatty pancreas; metabolic syndrome; obesity; pancreas; pancreatic disease From the

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Impact of qualitative endoscopic ultrasonography on fatty pancreas at a referral medical center

et al. 2021

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Background Taking advantage of the current advances in diagnostic imaging modalities, including endoscopic ultrasonography (EUS), and due to the increased attention to ectopic fat accumulation in the pancreas following the rising trend of metabolic syndrome, we qualitatively assessed the clinical implication of pancreatic steatosis by EUS in this study. Methods The study included 243 patients that were divided into four groups. The correlation between the average echogenicity of the pancreas and that of the control organs and the key clinical data of all study patients were collectively analyzed. The cut‐off point of the pancreas‐control (PC) ratio in EUS and liver‐control (LC) ratio on abdominal ultrasound were determined from the population distribution and the obtained median values. Results With the cut‐off point of 1.30 for the PC ratio and 1.20 for the LC ratio, sex, the Brinkman index, habitual alcohol drinkers, and fatty pancreas were significant factors. The associations between each relevant factor in fatty pancreas, metabolic syndrome in the fatty liver group, and age in the pancreatic cancer group were all significant in the analysis. In addition, we investigated whether the PC ratio differed according to age and staging in pancreatic cancer patients. Interestingly, the PC ratio was lower in the advanced stage group than in the early‐stage group. Conclusion Our results suggest that, irrespective of the degree, ectopic fat infiltration in the pancreas could be a specific clinical phenotype of serious pancreatic diseases, including pancreatic cancer, especially in high‐risk patients.

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Prevalence and factors associated with nonalcoholic fatty pancreas disease and its severity in China

Cited by 48 publications

References 31 publications

The association between pancreas steatosis and metabolic syndrome: A systematic review and meta‐analysis

The association between pancreas steatosis and metabolic syndrome: A systematic review and meta‐analysis

Nonalcoholic Fatty Pancreas Disease

Impact of qualitative endoscopic ultrasonography on fatty pancreas at a referral medical center

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