Prevalence and Effect of Genetic Risk of Thromboembolic Disease in Inflammatory Bowel Disease

Naito, Takeo; Botwin, Gregory J.; Haritunians, Talin; Li, Dalin; Yang, Shaohong; Khrom, Michelle; Braun, Jonathan; Cho, Judy H.; Silverberg, Mark S.; Duerr, Richard H.; Rioux, John D.; Brant, Steven R.; Schumm, P.-M.; Abbou, Lisa; Mengesha, Emebet; Stevens, Christine; Masamune, Atsushi; Daly, Mark J.; McGovern, Dermot P.

doi:10.1053/j.gastro.2020.10.019

Cited by 12 publications

(10 citation statements)

References 31 publications

(40 reference statements)

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“…Gene set enrichment analysis 58 summarized in Figure 1B highlights engagement of multiple pathways previously implicated in adverse outcomes in IBD, including TNF and interferon signaling, and various signatures of inflammation and immune response. 59,60 We recently showed in an admixed population that African ancestry also upwardly biases gene expression in several of these pathways 61 but was not found to be driving the rectal profiles in this largely European ancestry dataset.…”

Section: Resultsmentioning

confidence: 81%

Stratification of risk of progression to colectomy in ulcerative colitis via measured and predicted gene expression

Nagpal

Gettler

et al. 2021

The American Journal of Human Genetics

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Section: Resultsmentioning

confidence: 81%

Stratification of risk of progression to colectomy in ulcerative colitis via measured and predicted gene expression

Nagpal

Gettler

et al. 2021

The American Journal of Human Genetics

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“…The existence of more than one genetic factor may increase the risk of developing recurrent thrombotic events. Several factors can influence increased TED risk, including disease activity, hospitalization, age, pregnancy, medications, surgery, and genetics [ 9 ].…”

Section: Discussionmentioning

confidence: 99%

The Demographic Data and Prevalence of Thromboembolic Events Among Inflammatory Bowel Disease Patients in Buraydah, Al-Qassim Region

Alodheilah¹,

Alnujeidi²,

AlDhuwayhi³

et al. 2022

Cureus

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IntroductionInflammatory bowel diseases (IBD) (Crohn's disease (CD) and ulcerative colitis (UC)) are considered among the commonest gastrointestinal (GI) tract diseases manifesting with chronic, recurring episodes of gut inflammation, especially in the colon. Each disease has its pattern, symptoms, severity of pain, extension, management, and prognosis. However, these diseases share most of the various complications, including the GI tract and extending it to other systems such as musculoskeletal, skin, liver, and pulmonary systems. ObjectivesWe aim to identify the demographic data, prevalence, risk factors, clinical presentation, and management (medications given and investigations ordered) of thromboembolic events (TEE) among inflammatory bowel disease patients at King Fahad Specialist Hospital (KFSH) in Buraydah, Al-Qassim, Saudi Arabia. Materials and methodsThis is a retrospective, cross-sectional study. All included patients with IBD who meet the inclusion criteria between January 2020 and January 2022 in KFSH were reviewed, and data were analyzed using the Statistical Package for the Social Sciences (SPSS) Statistics version 23.0 (IBM Corp., Armonk, NY, USA).

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“…Genetic risk seems to be associated with development of VTE in patients with IBD ( 52 ). The contribution of hereditary or acquired thrombophilia to VTE development in patients with IBD is likely to be limited ( 16 , 32 , 53 ), and routine screening should thus be reserved for unusual cases.…”

Section: Managementmentioning

confidence: 99%

Venous Thromboembolic Complications in Pediatric Gastrointestinal Diseases: Inflammatory Bowel Disease and Intestinal Failure

et al. 2022

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In children with gastrointestinal disorders such as inflammatory bowel disease (IBD) and intestinal failure (IF), the risk of venous thromboembolism (VTE) is increased. VTE may lead to pulmonary embolism, sepsis and central line infection, stroke and post-thrombotic syndrome. The purpose of this review is to summarize current knowledge and recent advances around VTE management in pediatric gastroenterology with a focus on IBD and IF. The VTE incidence in children with IBD is reported to be around 4–30 per 10,000 patient-years, with higher incidences for hospitalized children. While in general, IF is less common than IBD, the VTE incidence in children with IF is around 750 per 10,000 patient-years. The most common risk factors for development of VTE involve deviations leading to Virchow's triad (endothelial damage, stasis, and hypercoagulability) and include active inflammation, particularly with colonic involvement, presence of a central venous catheter, underlying thrombophilia, reduced mobility, surgery, and hospitalization. Classes of anticoagulants used for treatment of VTE are low molecular weight heparins and vitamin K antagonists. However, the use of direct oral anticoagulants for treatment or prevention of VTE has not been studied in this pediatric population yet. Pediatric gastroenterologists apply different VTE prevention and treatment strategies due to lack of literature and lack of consensus. We discuss the role of primary and secondary prophylactic use of anticoagulants, and provide tools and recommendations for screening, prevention and management for the specific pediatric populations.

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Prevalence and Effect of Genetic Risk of Thromboembolic Disease in Inflammatory Bowel Disease

Abstract: Author names in bold designate shared co-first authorship.

Cited by 12 publications

References 31 publications

Stratification of risk of progression to colectomy in ulcerative colitis via measured and predicted gene expression

Stratification of risk of progression to colectomy in ulcerative colitis via measured and predicted gene expression

The Demographic Data and Prevalence of Thromboembolic Events Among Inflammatory Bowel Disease Patients in Buraydah, Al-Qassim Region

Venous Thromboembolic Complications in Pediatric Gastrointestinal Diseases: Inflammatory Bowel Disease and Intestinal Failure

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