Prevalence and distribution of human papillomavirus genotypes among women attending gynecology clinics in northern Henan Province of China

Wang, Xiangpeng; Yuan, Shuai; Wei, Xiaofei; Wang, Guanyu; Sun, Ruili; Wang, Mingyong; Zhao, Lijun

doi:10.1186/s12985-021-01732-8

Cited by 31 publications

(30 citation statements)

References 34 publications

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“…We also presented age-specific prevalence of single, dual and multiple HPV infections. The single genotype infection in aged ≤ 24 years group was higher than that of dual and multiple infections in other age groups, which also observed in northern Henan province of China [ 37 ]. Young women are thought to have more frequent sexual activities, more than one partner and relatively inadequate immune response, which makes them have a higher probability of exposure to HPV infection.…”

Section: Discussionmentioning

confidence: 85%

Prevalence of cervicovaginal human papillomavirus infection and genotype distribution in Shanghai, China

Xiang

Dai

et al. 2022

Virol J

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Background The evaluation of human papillomavirus (HPV) prevalence rate dynamics and genotype distribution could support the adoption of more targeted prevention and treatment of cervical cancer. We aimed to assess the infection status and genotype characteristics of HPV among gynecological outpatients in Shanghai, China. Methods Clinical specimens were collected from patients attending gynaecological department of the Putuo Hospital, Shanghai University of Traditional Chinese Medicine, between January 2015 and December 2019. The cervicovaginal infection of 17 high-risk genotypes and 10 low-risk genotypes were analyzed by Luminex-based multiple assays. Results The overall HPV infection rate was 18.81% (95% CI 18.31–19.30%) in Shanghai city, with high-risk, low-risk and mixed high- and low-risk HPV prevalence being 11.65% (95% CI 11.24–12.06%), 4.19% (95% CI 3.94–4.44%) and 2.96% (95% CI 2.74–3.17%), respectively. The five most prevalent high-risk genotypes were HPV-52 (2.95%), HPV-16 (2.34%), HPV-58 (2.07%), HPV-53 (1.67%) and HPV-39 (1.36%). The most common low-risk genotype was HPV-61 (1.52%), followed by HPV-6 (1.29%) and HPV-81 (1.19%). Moreover, the coverage of HPV genotype by nonavalent vaccine was 10.42%, and non-vaccine-covered high-risk genotype was 7.70%. The 15–24 years age group demonstrated the highest HPV prevalence (43.14%), and significant differences were observed among different age groups (P < 0.001). Conclusions This study revealed the HPV prevalence and genotype distribution among women in Shanghai city, which could serve as guidance for HPV vaccination and preventative strategies against cervical cancer in this area.

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Section: Discussionmentioning

confidence: 85%

Prevalence of cervicovaginal human papillomavirus infection and genotype distribution in Shanghai, China

Xiang

Dai

et al. 2022

Virol J

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“…This study was a large-scale HPV screening study among women in the region, and the results were closely related to the unique research population. Results showed that the overall HPV infection rate in the regular screening population was 9.6%, which was significantly lower than the HPV infection rate in women who visited the gynaecology department of hospitals [ 35 , 36 ]. Although the hospital (gynaecology) patients were a selected group and were therefore likely to have a higher overall rate of HPV positive testing, the trends with age were the same in both the general population and the hospital population [ 33 , 37 , 38 ].…”

Section: Discussionmentioning

confidence: 99%

Epidemiological study of HPV infection in 40,693 women in Putian: a population study based on screening for high-risk HPV infection

et al. 2022

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Background The infection rate of human papillomavirus (HPV) is high in the coastal regions of China. However, the infection rate among high-risk genotypes of women in Putian City is unknown. Therefore, this study aimed to analyse the epidemiology of high-risk HPV infection among women in Putian and provide a reference for the diagnosis, treatment and vaccination of cervical cancer in this region. Methods The data used were obtained from the Chinese government’s public health program (“Cervical and Breast Cancer Screening Project”). A total of 40,693 female cervical cell exfoliation samples screened for high-risk HPV at the Affiliated Hospital of Putian University from July 2020 to December 2021 were enrolled. DNA was extracted using a fully automatic extractor. Then, 14 high-risk genotypes of HPV were detected by polymerase chain reaction. The characteristics of HPV infection, distribution of high-risk genotypes, infection types and thinprep cytologic test (TCT) classification at different age groups were analysed. Results Among the 40,693 samples, 3899 were infected with HPV, with an infection rate of 9.6%. Accordingly, HPV infection rates gradually increased with age, and statistically significant differences were observed among age groups (χ2 = 74.03, P < 0.01). The infection rates of high-risk HPV52, HPV58 and HPV16 were in the top three and increased with age. Single infection was dominant (84.7%), followed by double infections (12.7%). The cervical cytology of 3899 HPV-positive people can be classified into negative for intraepithelial lesion and malignancy (NILM, 88.0%), atypical squamous cells of undetermined significance (ASC-US, 6.6%), atypical squamous cells—cannot exclude high-grade squamous intraepithelial lesion (ASC-H, 1.4%), low-grade squamous intraepithelial lesion (LSIL, 3.2%) and high-grade squamous intraepithelial lesion (HSIL, 0.8%). HPV16 infection rate increased with increasing severity of cervical cytology (χ2trend = 43.64, P < 0.01), whereas the infection rates of HPV52 (χ2trend = 13.89, P < 0.01) and HPV58 (χ2trend = 13.50, P < 0.01) showed opposite trends. Conclusion The infection rate of female HPV high-risk screening in this region was 9.6% and mainly involved single infections. In addition, HPV16, HPV52 and HPV58 were closely related to the severity of cervical cytology. Effective screening, vaccination and education are needed. The 9-valent vaccine will be effective in reducing cervical pre-invasive disease. It would also be reasonable to state that the rising trend in HPV infection and high grade cytology with age emphasises the need to target older women with screening. Vaccination of younger women (aged ≤ 25) will lay the foundation for better cancer outcomes in the future.

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“…Also, HPV infection is recognized as a major causative agent in the development of cervical cancer which remains the fourth most common cancer among women worldwide with an estimated 569,847 new cases and 311,365 deaths in developing countries in 2018 [ 4 – 6 ]. Currently, more than 150 HPV genotypes have been identified and about 40 are known to transmit through sexual contact and to infect the anogenital region [ 7 – 9 ].…”

Section: Introductionmentioning

confidence: 99%

Prevalence of human papilloma virus (HPV) genotypes between outpatients males and females referred to seven laboratories in Tehran, Iran

Azhar

Yaghoobi²,

Mossalaeie³

et al. 2022

Infect Agents Cancer

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Background Human papilloma virus (HPV) causes the most common sexually-transmitted infection especially among sexually-active individuals. The aim of study was to characterize the molecular characterization of HPV genotypes between 5176 female and male patients. Methods HPV DNA was extracted from genital swabs of the study participants and amplified by Real Time Polymerase Chain Reaction (PCR). Genotyping was performed for 2525 cases using REALQUALITY RQ-Multi HPV Detection Kit for the identification of 14 high risk (HR) and 2 low risk (LR) HPV genotypes. Demographic figures were analyzed in correlation with virological data statistically. Results Out of 5176 cases from 7 laboratories, 2727 (53%) were positive for HPV, of which. 2372(87%) women and 355 (13%) men were HPV positive. However, in an intra-gender analysis, positive rate was higher in men (355/637, 55.7%) than in women (2372/4539, 52%; P value 0.007). HPV positive patients were younger than negative individuals. Positive rate was higher among age categories 20–40. Genotyping was performed for 2525 cases. Out of 1219 (48%) patients who contained single genotypes, 566 (22%) and 653 (26%) harboured HR and LR genotypes, respectively. In females and males, 1189 (54%) and 117 (37%) contained multiple genotypes. No substantial associations were found between different age categories and HR/LR and multiple genotypes distribution. Conclusion The prevalence of HPV infection in both genders was high. However, men had a higher rate of infection. These observations highlighted the necessity for a plan for targeted education to younger population in the society as well as application of infection control measures against HPV infection, especially in terms of general population mass HPV vaccination.

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Prevalence and distribution of human papillomavirus genotypes among women attending gynecology clinics in northern Henan Province of China

Cited by 31 publications

References 34 publications

Prevalence of cervicovaginal human papillomavirus infection and genotype distribution in Shanghai, China

Prevalence of cervicovaginal human papillomavirus infection and genotype distribution in Shanghai, China

Epidemiological study of HPV infection in 40,693 women in Putian: a population study based on screening for high-risk HPV infection

Prevalence of human papilloma virus (HPV) genotypes between outpatients males and females referred to seven laboratories in Tehran, Iran

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