Prevalence and Distribution of Developmental Defects of Enamel in the Primary Dentition of IVF Children of West Bengal

Kar, Sudipta; Sarkar, Subrata; Mukherjee, Ananya

doi:10.7860/jcdr/2014/8725.4639

Cited by 9 publications

(7 citation statements)

References 13 publications

(16 reference statements)

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“…Larger twin studies would enable further exploration of this association. With the exception of 1 Indian study that revealed no association between IVF and DDEs in the primary dentition, there have been limited investigations into the impact of IVF on dental health (Kar et al 2014). Higher rates of perinatal adverse outcomes and congenital abnormalities from pregnancies conceived via IVF have been attributed to parental (i.e., smoking) and technique-related factors, and these may also be important in the etiology of MIH and HSPM (Pinborg et al 2012).…”

Section: Discussionmentioning

confidence: 99%

Etiology of Hypomineralized Second Primary Molars: A Prospective Twin Study

et al. 2018

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The etiology of hypomineralized second primary molars (HSPM) is unclear, but genetic and environmental factors have been proposed. The aim of this study was to investigate the relative contribution of genes and environment to the etiology of HSPM and to identify potential environmental risk factors in a longitudinal twin cohort. Children from twin pregnancies ( N = 250) were recruited antenatally, and detailed demographic, health, and phenotypic data were collected at recruitment, 24- and 36-wk gestation, birth, and 18 mo of age. 25-Hydroxyvitamin D was quantified for mothers at 28-wk gestation and infants at birth. Dental examinations were conducted on the twins at 6 y of age to determine the presence, severity, and extent of HSPM per standardized criteria. To investigate associations of environmental risk factors with HSPM, multiple logistic regression models were fitted with generalized estimating equations to adjust for twin correlation. Within- and between-pair analyses were performed for unshared continuous variables: birthweight and birth 25-hydroxyvitamin D. Twin-twin concordance for monozygotic (MZ) and dizygotic (DZ) pairs was calculated and compared after adjusting for identified risk factors. A total of 344 twins underwent the 6-y-old dental assessment; HSPM occurred in 68 (19.8%). After adjusting for potential confounders, vitamin D levels at birth, infantile eczema, dizygosity, in vitro fertilization, socioeconomic position, and maternal smoking beyond the first trimester of pregnancy demonstrated the strongest associations with HSPM. Overall concordance for HSPM was 0.47 (95% CI, 0.32 to 0.62) with weak evidence ( P = 0.078) of higher concordance in MZ twins (0.63; 95% CI, 0.38 to 0.89) as compared with DZ twins (0.41; 95% CI, 0.24 to 0.58). After adjusting for known risk factors, there was no evidence ( P = 0.172) for an additive genetic influence. These findings suggest that shared and unshared environmental factors, such as maternal smoking later in pregnancy and infantile eczema, are important in the etiology of HSPM.

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Section: Discussionmentioning

confidence: 99%

Etiology of Hypomineralized Second Primary Molars: A Prospective Twin Study

et al. 2018

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“…These defects are likely to be developmental defect of enamel (DDE) in the primary dentition. The DDE in primary teeth are relatively common with prevalence ranging from 8.4% to 48.0% [31, 32] and in primary teeth of healthy children in developed countries ranging from 24% to 49% [33, 34]. Many risk factors have been associated with the development of DDE and it includes medical conditions [35, 36], social factors [37], medical problems during pregnancy [38], absence of breast feeding [38], nutritional problems [37], and mutation in the amino acid sequence of amelogenin gene [39].…”

Section: Discussionmentioning

confidence: 99%

Regional Odontodysplasia with Generalised Enamel Defect

Al-Mullahi

Toumba

2016

Case Reports in Dentistry

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Regional odontodysplasia (ROD) is uncommon developmental anomaly, which tends to be localised and involves the ectodermal and mesodermal tooth components. A five-year-old female was referred to Department of Child Dental Health at the Leeds Dental Institute regarding malformed primary teeth. On examination 64, 74, and 72 had localised hypomineralized enamel defect. The crown of 55 was broken down with only the root remaining below the gingival level. 54 has a yellowish brown discolouration with rough irregular surface. The upper anterior teeth show mild enamel opacity. Radiographically, 55 and 54 had thin radioopaque contour, showing poor distinction between the enamel and dentine and the classic feature of a wide pulp chamber. 15, 16, and 17 were developmentally delayed and were displaying the characteristic “ghost appearance.” Comprehensive dental care was done under local anaesthesia and it included extraction of the primary molars affected by ROD, stainless steel crown on 64, and caries prevention program. Fifteen months following the initial assessment the patient's oral condition remains stable and she is under regular follow-up at the department. Paediatric dentists should be aware of this anomaly as it involves both dentitions and usually requires multidisciplinary care.

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“…Debido a que fueron pocos los estudios encontrados que midieron simultáneamente los tres tipos de defectos, las comparaciones de los resultados de esta investigación, también se hicieron con estudios que midieron por separado las opacidades demarcadas y las opacidades difusas en dentición temporal. En los estudios que incluían población sistémicamente comprometida, sólo se tuvo en cuenta, para las comparaciones el grupo de individuos sin compromiso sistémico (7,16,20,25,27,28); y en estudios donde no aparece explícito el compromiso sistémico, se asumió que no existía (3,6,10,14,(17)(18)(19)(21)(22)(23)(24)26 La prevalencia de DDE para la población estudiada fue alta (74,2 %), sugiriendo que los DDE en dentición temporal no son tan infrecuentes como se ha especulado (14,25,29). A nivel internacional, se encuentran prevalencias menores como es el caso de Kar 8,5 % (16), Kim 12,7 % (7), Li 23,9 % (20), Lunardelli (17).…”

Section: Discusionunclassified

“…En los estudios revisados hay diversidad en: los índices utilizados para medirlos, los diseños metodológicos, la población estudiada y la presentación de resultados (3,6,7,10,14,(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28). Algunos han contemplado simultáneamente todos los DDE en poblaciones sistémicamente sanas y reportan prevalencias entre 24,4 % y 55,4 % (3,6,15,17,18,19 ); otros lo han hecho en pacientes con compromiso sistémico donde la prevalencia varía entre 8,5 % y 61,9 % (7,16,20,25,27,28); otros han estudiado solo opacidades difusas (también llamadas fluorosis), encontrando prevalencias desde 3 % hasta 99 % (14,(21)(22)(23)(24); y otros solo opacidades demarcadas arrojando prevalencias entre 76,6 % y 87 % (10,26). Bajo estas condiciones es difícil establecer la verdadera prevalencia de los DDE en dentición temporal, sin embargo, se especula que su presencia es baja (14,25,29).…”

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