Prevalence and distribution of antimicrobial resistance in effluent wastewater from animal slaughter facilities: A systematic review

Foyle, Leo; Burnett, Matthew J.; Creaser, Abbey; Hens, Rachel; Keough, Julia; Madin, Lauren; Price, Ruby; Smith, Hayley; Stone, Sheldon; Kinobe, Robert T.

doi:10.1016/j.envpol.2022.120848

Cited by 11 publications

(4 citation statements)

References 76 publications

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“…For example, SL often contains high levels of FOG (50% dw) and protein (37% dw), depending on the source (Table S2). Additionally, antibiotic resistance genes (ARGs) are commonly found in AM, , SL, and wastewater due to the extensive use of antibiotics and antiparasitic drugs in animal husbandry. , Therefore, AD of these waste streams, particularly under thermophilic conditions, can mitigate the spread of pathogens and ARGs . However, mono-digestion of SL, particularly under thermophilic conditions, is often inhibited by ammonia and VFAs, posing a challenge to digester stability. , While AM:SL AcoD likely contributes to digestor stability, it did not improve SMY compared with the mono-digestion of AM (ROM = 1.11, p < 0.05, n = 3).…”

Section: Resultsmentioning

confidence: 98%

“…For example, SL often contains high levels of FOG (50% dw) and protein (37% dw), depending on the source (Table S2). 17 Additionally, antibiotic resistance genes (ARGs) are commonly found in AM, 135,136 SL, 137 and wastewater 138 due to the extensive use of antibiotics and antiparasitic drugs in animal husbandry. 139,140 Therefore, AD of these waste streams, particularly under thermophilic conditions, can mitigate the spread of pathogens 141 and ARGs.…”

Section: Co-digestion Of Agricultural Wastes and Residuesmentioning

confidence: 99%

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Understanding Anaerobic Co-digestion of Organic Wastes through Meta-Analysis

Chuenchart,

Surendra,

Khanal

2024

ACS EST Eng.

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Anaerobic co-digestion (AcoD) is becoming increasingly popular in the biogas industry for its numerous advantages over mono-digestion, including balanced nutrient profiles, enhanced process stability, synergistic methane production, and reduced greenhouse gas emissions. However, varying results across AcoD studies highlight the need for an extensive meta-analysis of a large data set to better understand these synergies. Here, we compared methane yields from 432 data sets, based on the ratio of means, from AcoD and mono-digestion. The relative synergistic index (RSI) revealed synergistic effects in AcoD of lignocellulosic biomass with animal manures, particularly pig (RSI = 1.91) and chicken manures (RSI = 1.71). Due to its rapid biodegradability, food waste AcoD also demonstrated synergistic effects with both animal manures (RSI = 1.28) and lignocellulosic biomass (RSI = 1.41). After regrouping data by high-carbon cosubstrates, interpretable machine learning models identified temperature, which accelerates the hydrolysis of lignocellulosic biomass and emulsification of fats, oils, and grease, as the key factor influencing methane yield. Furthermore, experimental validation using food waste and sewage sludge co-digestion confirmed the superiority of multivariable linear regression in predicting specific methane yield over other models in terms of simplicity and efficiency.

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Section: Resultsmentioning

confidence: 98%

Section: Co-digestion Of Agricultural Wastes and Residuesmentioning

confidence: 99%

Understanding Anaerobic Co-digestion of Organic Wastes through Meta-Analysis

Chuenchart,

Surendra,

Khanal

2024

ACS EST Eng.

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“…Antibiotic resistance is a critical One Health issue 4 , profoundly affecting humans, animals, and the environment, impacting even the most fundamental resource for life: water. The presence of antibiotic-resistant genes (ARGs) and ARBs often can be attributed to effluents from hospitals, farms, and sewage systems, illustrating the interconnectedness of human activities and the broader environmental impact of AR [5][6][7][8] . As wastewater treatment plants (WWTPs) operate at the human-environment interface, they play a crucial role in both managing and understanding the global health effects of AR [9][10][11] .…”

Section: Introductionmentioning

confidence: 99%

ROS-Induced Oxidative Stress Causes Enrichment and Emergence of Antibacterial Resistance in Conventional Activated Sludge Process

Manna,

Zhou,

Singhal

2024

Preprint

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Conventional activated sludge (CAS) processes represent significant reservoirs of antibacterial resistance genes (ARGs). However, the mechanisms governing ARG proliferation (enrichment and emergence) in CAS remain poorly understood. We hypothesize that Reactive Oxygen Species (ROS), generated by oxygenation in aeration tanks, govern ARG proliferation. Shotgun-metagenomics assessment of ARG abundance across treatment stages of two plants handling hospital effluents revealed a substantial reduction in total ARGs in treated effluent. However, specific ARGs conferring resistance to beta-lactams, tetracyclines, aminoglycosides, rifamycins, macrolides, and other drug classes showed marked increase in CAS, exhibiting correlations with ROS stress response genes. Notably, many of these ARGs emerged in the CAS and were absent in upstream processes. Proof-of-concept experiments demonstrated increased ROS and ARG levels under high dissolved oxygen (8 mg/L) compared to low oxygen (2 mg/L) conditions. Both ESKAPE and non-ESKAPE host pathogens in CAS harbored multiple shared ARGs, indicating horizontal gene transfer facilitated proliferation. ROS-induced stress responses, including antioxidant defense activation, cell damage, DNA mutation, metabolic adaptation, efflux pump activation, and enhanced transformation, could contribute to ARG enrichment/emergence. This study highlights that oxygenation in CAS inadvertently promotes ARG proliferation, underscoring the need to manage oxygen levels to control ROS-induced ARG proliferation and environmental dissemination.Abstract Figure

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“…Antibiotic residues, antibiotic-resistant bacteria, or ARGs are detectable in wastewater and constitute a study system that provides a wealth of information. In addition to the identification of antimicrobial resistance (AMR) by several microbiological techniques (Sims and Kasprzyk-Hordern, 2020;Chau et al, 2022;Foyle et al, 2023;Larsson et al, 2023;Pandey et al, 2023;Sharma et al, 2023), it is crucial to monitor and assess antibiotic presence in wastewater, and other environmental matrices to address the problem of AMR. WBE is potentially the most reliable approach to estimate antibiotics use (Henriot et al, 2024).…”

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confidence: 99%

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Prevalence and distribution of antimicrobial resistance in effluent wastewater from animal slaughter facilities: A systematic review

Cited by 11 publications

References 76 publications

Understanding Anaerobic Co-digestion of Organic Wastes through Meta-Analysis

Understanding Anaerobic Co-digestion of Organic Wastes through Meta-Analysis

ROS-Induced Oxidative Stress Causes Enrichment and Emergence of Antibacterial Resistance in Conventional Activated Sludge Process

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