Prevalence and determinants of reticular pseudodrusen in the Russian Ural Eye and Medical Study

Бикбов, М.М.; Kazakbaeva, Gyulli; Rakhimova, Ellina; Rusakova, Iuliia A; Gilmanshin, Timur R.; Зайнуллин, Р.М.; Panda‐Jonas, Songhomitra; Fakhretdinova, Albina A; Tuliakova, Azaliia M; Safiullina, Kamilia R; Bolshakova, Natalia I; Gizzatov, Ainur V; Ponomarev, Ildar P; Jonas, Jost B

doi:10.1111/aos.15145

Cited by 2 publications

(3 citation statements)

References 33 publications

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“…Our study confirms the previously reported association of SDD with age [ 13 , 15 ], and we found that only two relatives with SDD had AMD-defining retinal lesions such as intermediate/large drusen or pigmentary abnormalities but showed small alterations such as druplets. This may indicate an independency of SDD from AMD (particularly in the early course of disease) and/or suggest that SDD could be a precursor in those at risk.…”

Section: Discussionsupporting

confidence: 93%

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Prevalence and determinants of subretinal drusenoid deposits in patients’ first-degree relatives

Mauschitz,

Hochbein,

Klinkhammer

et al. 2023

Graefes Arch Clin Exp Ophthalmol

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Purpose Subretinal drusenoid deposits (SDDs) are distinct extracellular alteration anterior to the retinal pigment epithelium (RPE). Given their commonly uniform phenotype, a hereditary predisposition seems likely. Hence, we aim to investigate prevalence and determinants in patients’ first-degree relatives. Methods We recruited SDD outpatients at their visits to our clinic and invited their relatives. We performed a full ophthalmic examination including spectral domain–optical coherence tomography (SD-OCT) and graded presence, disease stage of SDD as well as percentage of infrared (IR) en face area affected by SDD. Moreover, we performed genetic sequencing and calculated a polygenic risk score (PRS) for AMD. We conducted multivariable regression models to assess potential determinants of SDD and associations of SDD with PRS. Results We included 195 participants, 123 patients (mean age 81.4 ± 7.2 years) and 72 relatives (mean age 52.2 ± 14.2 years), of which 7 presented SDD, resulting in a prevalence of 9.7%. We found older age to be associated with SDD presence and area in the total cohort and a borderline association of higher body mass index (BMI) with SDD presence in the relatives. Individuals with SDD tended to have a higher PRS, which, however, was not statistically significant in the multivariable regression. Conclusion Our study indicates a potential hereditary aspect of SDD and confirms the strong association with age. Based on our results, relatives of SDD patients ought to be closely monitored for retinal alterations, particularly at an older age. Further longitudinal studies with larger sample size and older relatives are needed to confirm or refute our findings.

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Section: Discussionsupporting

confidence: 93%

“…All these findings point at different underlying disease pathways in presence of SDD prior leading towards outer retinal atrophy compared to eyes without SDD [ 10 ]. However, overall prevalence estimates vary significantly from 0.41 to 18.1% between studies depending on imaging modalities [ 11 – 15 ].…”

Section: Introductionmentioning

confidence: 99%

Prevalence and determinants of subretinal drusenoid deposits in patients’ first-degree relatives

Mauschitz,

Hochbein,

Klinkhammer

et al. 2023

Graefes Arch Clin Exp Ophthalmol

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“…As also described in detail previously, all study participants underwent a detailed interview which was conducted by trained social workers and consisted of more than 250 standardized questions on the socio-economic background and lifestyle parameters, depression and anxiety, and known diagnosis and therapy of major diseases 23,24,[26][27][28] . The series of examinations included anthropometry, blood pressure measurement, handgrip dynamometry, spirometry, biochemical analysis of blood samples taken under fasting conditions, and ophthalmologic examinations.…”

Section: Examinationsmentioning

confidence: 99%

Prevalence and associations of dry eye disease and meibomian gland dysfunction in the ural eye and medical study

Бикбов

Gilmanshin

Зайнуллин

et al. 2022

Sci Rep

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To assess the prevalence of dry eye disease (DED) and Meibomian gland dysfunction (MGD) in a population in Russia. The population-based Ural Eye and Medical Study was conducted in an urban and rural region in Bashkortostan/Russia and included 5899 (80.5%) out of 7328 eligible persons, aged 40 + years. DED and MGD were assessed by Schirmer´s test, slit-lamp based examination of the Meibomian glands, and an interview with DED-related questions. The study included 5153 (87.4%) individuals with DED and MGD assessments (mean age: 58.5 ± 10.5 years). The mean Schirmer´s test result was 11.8 ± 6.8 mm and 12.5 ± 7.1 mm for the right/left eye, with a result of ≤ 5 mm measured in 1098 (21.3%; 95% confidence intervals (CI) 20.2, 22.4) of the worse eyes. The mean subjective dry eye symptoms score was 1.37 ± 1.82. MGD grade 1 (telangiectasia at the lid margin), 2, 3, 4 or any grade in the worse eye was diagnosed in 901 (21.1%), 1161 (27.1%), 158 (3.7%), 32 (0.7%), and 2252 (52.6%; 95% CI 51.1, 54.1) eyes respectively. The prevalence of DED diagnosis #1, #2 and #3 (Schirmer´s test ≤ 5 mm, and dry eye score ≥ 1, ≥ 2, and ≥ 3, respectively), #4 (dry eye score ≥ 1, Schirmer test ≤ 5 mm, MGD grade 1 +), and #5 (dry eye score ≥ 1, Schirmer test ≤ 5 mm, MGD grade 2 +) were 598/5142 (11.6%), 426/5153 (8.3%), 273/5142 (5.3%), 335/5142 (6.5%), and 186/5142 (3.6%), respectively. Mean depression score as applied was 5.1 ± 3.8. Higher DED prevalence (definition #4) was associated (multivariable analysis) with female sex (odds ratio (OR) 1.71; 95% CI 1.31, 2.22; P < 0.001), higher depression score (OR 1.04; 95% CI 101, 1.07; P = 0.009), and higher prevalence of thyroid disease history (OR 1.63; 95% CI 1.19, 2.24; P = 0.006). DED and MGD were common in this rural and urban population, and their prevalence was associated with female sex, thyroid disease, and depression.

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Prevalence and determinants of reticular pseudodrusen in the Russian Ural Eye and Medical Study

Cited by 2 publications

References 33 publications

Prevalence and determinants of subretinal drusenoid deposits in patients’ first-degree relatives

Prevalence and determinants of subretinal drusenoid deposits in patients’ first-degree relatives

Prevalence and associations of dry eye disease and meibomian gland dysfunction in the ural eye and medical study

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