Prevalence and determinants of left ventricular hypertrophy and remodelling patterns in hypertensive patients: the St. Petersburg study

Conrady, A. O.; Rudomanov, O. G.; Zaharov, D. V.; Krutikov, A. N.; Vahrameeva, N. V.; Yakovleva, O. I.; Alexeeva, Nina; Shlyakhto, Е. V.

doi:10.1080/08037050410031855

Cited by 32 publications

(26 citation statements)

References 37 publications

(52 reference statements)

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“…Due to the aging of general population in China, it demonstrated that the incidence of LVH would increase. Also, both SBP and BMI were associated with LVH after adjusted for other risk factors, consistented with the result of published studies [32, 35]. …”

Section: Discussionsupporting

confidence: 91%

Prevalence and risk factors of abnormal left ventricular geometrical patterns in untreated hypertensive patients

Pei

Shao

et al. 2014

BMC Cardiovasc Disord

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BackgroundThe various prevalence of LVH and abnormal LV geometry have been reported in different populations. So far, only a few reports are available on the prevalence of LV geometric patterns in a large Chinese untreated hypertensive population.MethodsA total of 9,286 subjects (5167 men and 4119 women) completed the survey and 1641 untreated hypertensive patients (1044 males and 597 females) enrolled in the present study. The LV geometry was classified into four patterns: normal; abnormal,defined as concentric remodeling;concentric or eccentric hypertrophy based on the values of left ventricular mass index (LVMI) and relative wall thickness (RWT). Logistic regression model was applied to determine the odds ratio (OR) and 95% confidence intervals (CI) of the risk factors of left ventricular hypertrophy.ResultsThe prevalence of LVH was 20.2% in untreated hypertensive patients, much higher in women (30.8%) than in men (14.2%) (P < 0.01). The prevalence of LV geometrical patterns was 34.9%, 11.1%, 9.1% for concentric remodeling, concentric and eccentric hypertrophy,respectively. After adjustment by using Logistic regression model, the risk factors for LVH and abnormal LV geometry were age, female, systolic blood pressure, and body mass index. And low high density lipoprotein maybe a positive factor.ConclusionsThe prevalence of LVH and abnormal LV geometric patterns was higher in women than in men and increased with age. It is crucial to improve the awareness rate of hypertension and control the risk factors of CV complications in untreated hypertensive population.

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Section: Discussionsupporting

confidence: 91%

Prevalence and risk factors of abnormal left ventricular geometrical patterns in untreated hypertensive patients

Pei

Shao

et al. 2014

BMC Cardiovasc Disord

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“…Finally, information on gender-related LVH patterns were limited to a few studies (n ¼ 5 including 4384 patients, 2259 men). 13,14,17,21,36 Eccentric LVH prevalence tended to be higher in women than in men (42 --61 versus 32 --45%, respectively, P ¼ 0.13); concentric hypertrophy had a similar range in both genders (24 --33 versus 25 --32%).…”

Section: Type Of Lvhmentioning

confidence: 92%

“…27) to 180±29 mm Hg, 35 and diastolic BP from 75 ± 12 mm Hg 27 to 100 ± 9 mm Hg. 21,24 As many as 993 patients (2.6%) had previous CV events. 13,34,35,41 The overall prevalence of type-2 diabetes (26 studies, 34 328 patients) and obesity (11 studies, 22 473 patients) was 9.6% and 27.1%, respectively ( Figure 2).…”

Section: Characteristics Of the Studiesmentioning

confidence: 99%

Prevalence of left-ventricular hypertrophy in hypertension: an updated review of echocardiographic studies

et al. 2011

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on behalf of the Italian Society of Hypertension Left-ventricular hypertrophy (LVH) is a cardinal manifestation of hypertensive organ damage associated with an increased cardiovascular (CV) risk. We reviewed recent literature on the prevalence of LVH, as assessed by echocardiography, in order to offer an updated information on the magnitude of subclinical alterations in LV structure in contemporary human hypertension. A MEDLINE search using key words 'left ventricular hypertrophy', 'hypertension', 'echocardiography' and 'cardiac organ damage' was performed in order to identify relevant papers. Full articles published in English language in the last decade, (1 January 2000 --1 December 2010), reporting studies in adult or elderly individuals, were considered. A total of 30 studies, including 37 700 untreated and treated patients (80.3% Caucasian, 52.4% men, 9.6% diabetics, 2.6% with CV disease) were considered. LVH was defined by 23 criteria; its prevalence ranged from 36% (conservative criteria) to 41% (less conservative criteria) in the pooled population. LVH prevalence was not different between women and men (range 37.9 --46.2 versus 36.0 --43.5%, respectively). Eccentric LVH was more frequent than concentric hypertrophy (range 20.3 --23.0 versus 14.8 --15.8, respectively, Po0.05); concentric phenotype was found in a consistent fraction (20%) of both genders. Despite the improved management of hypertension in the last two decades, LVH remains a highly frequent biomarker of cardiac damage in the hypertensive population. Our analysis calls for a more aggressive treatment of hypertension and related CV risk factors leading to LVH. INTRODUCTIONLeft ventricular hypertrophy (LVH) secondary to arterial hypertension is a complex cardiac phenotype resulting from the response of myocyte and non-myocyte components to mechanical and neuro-humoral stimuli. 1 Although the mechanisms underlying this process remain incompletely understood, available evidence from the last two decades indicates that chronic haemodynamic overload has a driving role in activating LV myocardial growth; in turn, non-haemodynamic variables (that is, genetic, ethnic, environmental and hormonal factors) modulate the extent (and type) of the hypertrophic response. 2 --4 LVH in hypertensive patients may be regarded as a powerful, independent biomarker reflecting the impact of pressure overload as well as of several risk factors 5 on the heart.Routinely assessed LVH by electrocardiography or more accurately by echocardiography, is a strong determinant of cardiovascular (CV) prognosis over and beyond conventional risk factors in both population-based studies and in selected hypertensive cohorts. 6 --8 Initial levels of LV mass and mass reduction during antihypertensive treatment define CV risk related to subclinical cardiac damage 9 and influence therapeutic strategies. 10 In recent years, observational and interventional studies addressing hypertensive LVH performed worldwide 5 --9,11,12 offered us the opportunity to update available information o...

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“…Conrady et al reported that LVMI increases with advancing age in hypertensive patients, and they showed that the relation of LVMI to age could be explained by increasing hypertensive duration (25). The older hypertensive patients might have a prolonged opportunity to acquire LV load, because LV load may be accumulated for a certain period before it is sufficient to affect LVM.…”

Section: Influence Of Age On the Association Between Carotid Aix And Lvmmentioning

confidence: 99%

The Influence of Wave Reflection on Left Ventricular Hypertrophy in Hypertensive Patients Is Modified by Age and Gender

et al. 2008

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It has been established that a positive association exists between the augmentation index (AIx) and left ventricular mass (LVM) in hypertensives, but it remains unclear whether this association is affected by age or gender. The aim of the study was to assess the effect of age and gender on the association between carotid AIx and LVM in hypertensive patients. We performed arterial tonometry and echocardiography in 512 treated hypertensive patients who were divided into 4 groups by gender and age (older or younger than 65 years). Correlations between carotid

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Prevalence and determinants of left ventricular hypertrophy and remodelling patterns in hypertensive patients: the St. Petersburg study

Cited by 32 publications

References 37 publications

Prevalence and risk factors of abnormal left ventricular geometrical patterns in untreated hypertensive patients

Prevalence and risk factors of abnormal left ventricular geometrical patterns in untreated hypertensive patients

Prevalence of left-ventricular hypertrophy in hypertension: an updated review of echocardiographic studies

The Influence of Wave Reflection on Left Ventricular Hypertrophy in Hypertensive Patients Is Modified by Age and Gender

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